Dispensing home nebulizers for acute wheezing from the hospital is cost-effective.

The objective was to investigate the use characteristics of home nebulizers and to measure the benefit gained from dispensing home nebulizers (compared with their cost) to patients from the hospital. During the study period, August 28,1996 to May 17,1997, a sample of 232 of the 291 entries from a log of home nebulizers dispensed by the hospital respiratory care department were surveyed over the telephone. Of the 232 study subjects under the age of 21, a telephone interview of a guardian or supervising adult was completed in 106 subjects (46%) a mean of 43 weeks after the home nebulizer was prescribed (47% of the cohort received their home nebulizers from the inpatient service and another 47% were discharged with home nebulizers from the emergency department (ED)). An average of 3.6 estimated additional ED visits and 5.4 office/clinic visits for each patient were prevented by the home nebulizer. The benefit (savings from reduced ED and office visits alone) to cost ratio estimates range from $855:$90 to $1710:$90 or more. The overwhelming majority of the patients felt that the home nebulizer was a good idea, it was easy to use, they had no problems with the nebulizer and they received adequate training for home nebulizer use. Home nebulizers are a cost-effective means of providing home nebulized albuterol for selected outpatients. Hospital inpatient units and EDs which have the ability to dispense a home nebulizer, have an additional therapeutic option available for selected patients who may benefit from it. Medical insurance companies should fully support (ie, pay for) home nebulizers because it is cost effective. If there is any concern about the reliability of the patient to follow-up with their primary physician, the patient's primary physician should be contacted to discuss the feasibility of discharging the patient with a home nebulizer.

A blinded, randomized, paired, placebo-controlled trial of 20-minute EMLA cream to reduce the pain of peripheral i.v. cannulation in the ED.

A eutectic mixture of local anesthetics (EMLA) in cream form has been used as a topical anesthetic to reduce the pain of procedures penetrating the skin. It is generally applied for 45 to 60 minutes before the painful procedure. The purpose of this study was to determine whether a 20-minute application of EMLA is useful in reducing the pain of routine peripheral intravenous cannulation in the emergency department (ED). A blinded, randomized, placebo-controlled, paired trial compared the pain of intravenous cannulation in both hands of study subjects: one hand was treated with 20-minute EMLA cream and the other hand was treated with 20-minute placebo cream. Forty subjects identified the more painful hand and scored pain measurements of each hand using a 10-cm visual analog scale. These data failed to demonstrate any significant benefit of EMLA compared with placebo. EMLA is not useful for intravenous cannulation when used for 20-minute application times. There may be more effective and less costly ways of reducing the pain of intravenous cannulation that patients would prefer.

Emergency department versus office setting and physician/patient kinship effects in the diagnostic and therapeutic choices of febrile children at risk for occult bacteremia.

BACKGROUND: Given the controversy of selecting a diagnostic and treatment approach for the febrile child at risk for occult bacteremia, the purpose of this study is to survey the diagnostic and treatment strategies chosen by pediatricians for a febrile child at risk for occult bacteremia seen in three different settings (private office, emergency department, their own child) to see if any differences exist. STUDY DESIGN: Survey of pediatricians given a case scenario of a febrile female child without a source of the fever presenting in three different clinical settings: 1) Office. 2) Emergency Department (E.D.). 3) Pediatrician's daughter. RESULTS: 138 pediatrician surveys were tabulated. Pediatricians ordered the most tests and empiric antibiotic treatments in the E.D., the fewest tests and empiric antibiotic treatments on their daughter, and intermediate frequency of tests and empiric antibiotic treatments in the office. Roughly half the pediatricians ordered the same level of tests in all three clinical settings, while the other half varied their test ordering in the different clinical settings. CONCLUSION: The clinical setting has an effect on the diagnostic and treatment strategies chosen when evaluating a febrile child at risk for occult bacteremia with patients seen in the E.D. receiving more laboratory tests and antibiotic treatment compared to office patients. Kinship also has an effect, with a child (daughter in this instance) of a pediatrician receiving the fewest laboratory tests and antibiotic treatment.

Stool appearance in intussusception: assessing the value of the term "currant jelly".

This study surveyed the stool appearance descriptions of 107 inpatient children with intussusception. Fifty-six patients presented with grossly bloody stools (passed spontaneously), 10 of which were determined on chart review to resemble currant jelly. Of the 51 patients without grossly bloody spontaneously passed stools, 35 patients had rectal examination results charted. Eight of these children had grossly bloody stools noted on rectal examination, 4 of which were determined on chart review to resemble currant jelly. While most of the grossly bloody stools were not consistent with pure currant jelly, the most common terms used in describing the grossly bloody stools were "bloody," "mucus," "red," and "diarrhea." Since stools truly resembling currant jelly account for a minority of the grossly bloody stools in intussusception, the term "currant jelly stools" should be assessed in the teaching of intussusception. Generic terms such as blood, mucus, burgundy, red, etc, are more objective and sensitive at identifying cases of intussusception. Junior physicians who are taught the classic presentation of intussusception with currant jelly stool should also be taught that intussusception should be considered in the differential diagnosis of children passing any type of bloody stool. As a result, physicians with limited experience will be more likely to appropriately consider the diagnosis of intussusception, permitting a more timely diagnosis and a better outcome.

Personal computer teleradiology interhospital image transmission of neonatal radiographs to facilitate tertiary neonatology telephone consultation and patient transfer.

OBJECTIVE: Our purpose was to study the ability of personal computer teleradiology (PCT) to improve the quality of communication between physicians during newborn infant transfers and consultations. STUDY DESIGN: In the first part of the study 36 radiographs of neonatal intensive care unit patients were transmitted by PCT. The pediatrician reviewed the original films and three neonatologists reviewed the PCT images. Their interpretations were scored by use of criteria established by a neutral reader. In the second part chest x-ray films (CXR) of 31 newborns weighing > 2000 gm with respiratory distress were transmitted by PCT. A pediatrician and three neonatologists participated in an exercise to simulate a telephone neonatology consultation. Patient severity assessments as measured by assignments to receive intermediate or intensive care were compared before and after neonatologists viewed the PCT image of the CXR. RESULTS: In part 1 of the study neonatologists correctly identified 98%, 91%, and 98% of the x-ray interpretation scoring items, whereas at best the pediatrician identified 82% of the scoring items (p = 0.002). In part 2 neonatologists correctly assigned patient care levels an average of 73% after reviewing a standard clinical profile and a written description of the infant's CXR. After reviewing a PCT image of the infant's CXR, patient care level assignments were correctly assigned an average of 67%. The interpretation of the PCT CXR image was consistent with the radiologic report of record in 90 of 93 interpretations (31 cases read by three neonatologists). CONCLUSIONS: PCT represents an inexpensive means to accurately send a radiographic image over the phone as part of a telephone consultation. Neonatologists were able to interpret teleradiology images more accurately than a pediatrician reviewing the original film. Although this did not result in an improvement in the neonatologists' ability to determine patient severity on the basis of the model used in part 2, their identification of serious radiographic findings missed by the pediatrician can only suggest that teleradiology may be beneficial in certain instances. Although verbal communication can often suffice in a telephone consultation or transfer, there may be specific instances when visualizing a radiographic image such as an x-ray film or computed tomographic scan can provide important information that cannot be optimally described verbally. Rural hospitals can form interhospital image transmission links with tertiary center resources.

The critically ill neonate in the emergency department.

Recognition of the high-risk mother and fetus is an essential component of resuscitation if it is to be organized, accurate, and successful. Although many high-risk factors put the neonate in jeopardy, the first responder or ED physician can plan the initial approach to resuscitation by knowing the answer to three questions: (1) Is there particulate meconium in the amniotic fluid? (2) Is the fetus/baby premature? and (3) Is a multiple gestation pregnancy expected? Although the ABCs (airway, breathing, circulation, chemical) of resuscitation adequately describe the parameters essential for adequate resuscitation, they do not relate to the actions necessary to accomplish this feat; therefore, it is important for participants in neonatal resuscitation to remember the acronym SOS--suction, oxygen, stimulation. Even infants with moderate depression (occasional respiratory effort) will generally respond to brief suctioning of the airway, 100% oxygen, and vigorous stimulation. If SOS is ineffective, PPV must be administered without hesitation. Resuscitation of the newborn is not a simple procedure, but rather a dynamic process involving continuous evaluation, action, and reassessment before, during, and after the actual resuscitation. A specially trained resuscitation team of physician, nurse, and respiratory therapist interacting in a dynamic evaluation approach is ideal but not practical for most community hospitals. Each hospital must develop its own protocol and train and maintain its resuscitation personnel. If each member of the team is prepared to take over in the absence of the others, neonatal resuscitation will remain fast, organized, and accurate.

Organic aciduria in neonatal multiple carboxylase deficiency.

A Samoan patient and a Saudi-Arabian patient were found to have abnormalities in the pattern of organic acid metabolites characteristic of 3-methylcrotonylglycinuria, propionic acidaemia and lactic acidosis. Both patients died early in life. The metabolic pattern is diagnostic of multiple carboxylase deficiency and an enzymatic diagnosis was made in a subsequent affected sibling of the first patient. Deficiency of the three carboxylases suggests a primary defect in the metabolism of biotin which is required for their activity. The importance of the recognition of the clinical picture is highlighted by the fact that this lethal disease is readily treated with biotin. These patients have prominent skin lesions which can serve as alerting signs for the diagnosis.

Daytime sleep stage organization in three-month-old infants.

Sleep monitoring at 3 months post term of clinically normal term infants, pre-term infants with no demonstrable pathologic clinical signs, and pre-term and term infants with a history of metabolic disorders show that these infants have EEG sleep stages resembling those seen in adults, as well as the adult pattern of sleep stage organization. The presence of NREM stage organization and stage sequencing suggest that sleep regulatory mechanisms are approaching a level of functional maturity in the human infant at 3 months post term. There is a significant relationship between sleep staging at 3 months post term and mental and motor performance at 12 months post term. In light of this, it is hypothesized that early bioelectric maturation may reflect the development of neural mechanisms which are also the substrate for later cognitive and behavioral functioning. Sleep stage organization at 3 months post term may be utilized as a benchmark of CNS development and for research on the pathophysiology of sleep disorders.

Multiple carboxylase deficiency: clinical and biochemical improvement following neonatal biotin treatment.

Multiple carboxylase deficiency is characterized by deficient activities of three biotin-dependent enzymes, propionyl coenzyme A carboxylase, pyruvate carboxylase, and beta-methylcrotonyl coenzyme A carboxylase. A newborn infant was seen with metabolic ketoacidosis, hyperammonemia, organic aciduria, seizures, and coma. Multiple carboxylase deficiency was subsequently confirmed by enzyme activity determinations in his peripheral blood leukocytes and cultured skin fibroblasts. The infant's neurologic and metabolic status improved markedly within a few days of administration of pharmacologic doses of oral biotin. His EEG, which was distinctly abnormal, became normal; his extensive computed tomography scan changes resolved, with the exception of ventricular dilation, over the next two months. After two weeks of biotin treatment the excretion of abnormal organic acid metabolites was reduced and his carboxylase activities increased to the normal range. However, the activities of these enzymes increased only to 30% to 55% of normal in fibroblasts incubated in supplemental biotin. This partial correction of enzyme activity differs from that observed in other individuals with multiple carboxylase deficiency and suggests biochemical heterogeneity in this disorder. Prompt diagnosis and intervention can avert some of the pathologic complications of this biotin-responsive condition.

Immediate and late ventillatory response to high and low O2 in preterm infants and adult subjects.

The differences in the immediate (30 sec or 1 min) and late (5 min) ventilatory response to high and low O2 have not been quantitated in preterm infants and adult subjects using the same methods. It was thought that these differences might explain the paradoxical ventilatory response to CO2 at various O2 concentrations in preterm infants (12). Thus, 9 preterm infants and 10 adult subjects were given 21% O2 to breathe and then 100 or 15% O2 for 5 min each. Adults also breathed 15% O2 before 100% O2 or 12% O2 in order to make their resting arterial PO2 more comparable to those of infants breathing 21% O2. The ventilatory response to 100% O2 was the same in preterm infants and adult subjects, but the late response to 15% O2 remained paradoxical, ventilation decreasing at 5 min by 18% in infants and increasing by 19% in adults. The authors conclude: 1) the traditional concept of the ventilatory response to 100% O2 being different in infants and adult subjects is false; 2) the notion that the response to low O2 is paradoxical in infants is correct; and 3) the data do not explain why the response to CO2 under various background concentrations of O2 in infants is the reverse of that in adult subjects, but the depressed ventilatory response to hypoxia in infants may justify, at least in part, their flatter response to CO2 during low O2 breathing.

The effect of lung inflation on the control of respiratory frequency in the neonate.

1. We have measured the relationship between tidal volume (V(T)) and the duration of inspiration (T(i)) and expiration (T(e)) for individual breaths (30 in each steady state).2. Ten pre-term and ten term infants were studied during steady state while breathing 21% O(2), then 21% O(2) plus 2 and 4% CO(2).3. In all infants, the average T(i) at the various chemical drives was remarkably constant, and did not decrease as the tidal volume increased. However, at any given level of respiratory drive, there was a slightly positive correlation of V(T) with T(i) and T(e) in 95% of the cases.4. In four pre-term and two term infants, T(e) increased with increasing respiratory drive. In these infants, therefore, instantaneous respiratory frequency (1/(T(i) + T(e))) actually decreased as lung volume increased.5. We suggest that T(i) is independent of V(T) within the range of volumes studied (up to 2 times the resting V(T)) and that changes in instantaneous respiratory frequency (1/(T(i) + T(e))) result from changes in T(e).

The effect of gestational age on the effective elastance of the respiratory system in neonates.

We measured the effective elastance of the respiratory system (E'RS) in 38 "healthy" neonates, gestational ages ranging from 28-42 weeks. E'RS was calculated by dividing the inspiratory pressure generated after nasal occlusion by the tidal volume of the breath preceding occlusion (E'RS = P/VT). E'RS decreased from 790 +/- 0.070 cm H2O/liter at 30.4 +/- 0.4 weeks of gestation to 520 +/- 0.030 at 34.5 +/- 0.3 weeks (P less than 0.01); then to 340 +/- 0.020 at 40 +/- 0.2 weeks (P less than 0.01). E'RS corrected for lung volume ("specific" E'RS) were 32 +/- 2,32 +/- 4, and 28 +/- 2 cm H2O at the above gestational ages, respectively (P greater than 0.05). We suggest: (1) the increased E'RS observed in preterm infants is lung volume dependent. Changes in lung volume may alter the geometry of the thorax, and therefore, the force/length characteristics of the respiratory muscles; (2) this increased E'RS is not of much benefit to preterm infants who have little respiratory stability when E'RS is maximum; and (3) if E'RS is an index of mechanical stability, apnea in preterm infants is independent of the mechanical properties of the respiratory system.

The immediate ventilatory response to added inspiratory elastic and resistive loads in preterm infants.

We measured the changes in tidal volume, duration of the various phases of the respiratory cycle, and peak nasal pressure during elastic and resistive loading in preterm infants. Values were calculated during the first loaded breath, when chemical drive was unchanged. Tidal volume decreased by equivalent percentages with resistive loads of 400, 900, and 2,400 cm H2O/liter/sec, and elastic loads of 330, 1,000, and 3,000 cm H2O/liter. Infinite load was also applied (nasal occlusion). Inspiratory duration (ti) was prolonged during resistive loading, as compared with elastic loading (P less than 0.05). Changes in expiratory duration (Te) were not different with both loads (P greater than 0.05). Total duration of the respiratory cycle (T), however, tended to increase in relation to control, more so with resistive loads. Peak nasal pressure was greater with resistive than with elastic loads ( less than 0.025). We suggest that (1) preterm infants, like adult subjects and other animal species, increase inspiratory duration with resistive loads as compared with elastic loads; (2) T of the first loaded breath tends to increase with progressively larger loads and, consequently, instantaneous frequency tends to decrease; and (3) if peak nasal pressure reflects tension developed by the respiratory muscles, then the latter does not offer the inhibitory information needed to terminate inspiration.