1.
J Chromatogr
; 414(1): 242-7, 1987 Feb 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3571390
2.
J Pharm Pharmacol
; 38(11): 840-2, 1986 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2879016
RESUMO
The pharmacokinetics and tissue distribution of pyrimethamine have been determined in the rat. Following administration of pyrimethamine alone, drug concentrations declined biexponentially. By contrast, in the presence of mefloquine, the decline in pyrimethamine concentration more closely fitted a monoexponential pattern and the AUC0-6h for pyrimethamine was significantly reduced. Significantly more pyrimethamine was recovered from the livers but less from the lungs of the mefloquine-dosed rats compared with control. This study outlines a potentially clinically relevant drug interaction.