RESUMO
Two adult dogs were evaluated for hypercalcemia. Diagnostic evaluation identified elevated parathyroid hormone-related protein (PTHrP) and presumptive humoral hypercalcemia of malignancy. At necropsy, schistosomiasis was diagnosed. North American schistosomiasis is caused by Heterobilharzia americana. Clinical findings may include dermatitis, coughing, diarrhea, and anorexia. Clinicopathological findings may include hypercalcemia, hyperglobulinemia, hypoalbuminemia, anemia, and eosinophilia. Diagnosis by fecal examination is difficult. Praziquantel or fenbendazole treatment may be curative or palliative. These are the first reported cases of hypercalcemia with elevated PTHrP in animals without diagnosed malignancy. Elevation of PTHrP has not been previously reported in hypercalcemic humans or in animals with granulomatous inflammation.
Assuntos
Doenças do Cão/diagnóstico , Hipercalcemia/veterinária , Proteínas/metabolismo , Esquistossomose/veterinária , Animais , Diagnóstico Diferencial , Doenças do Cão/sangue , Cães , Feminino , Hipercalcemia/sangue , Hipercalcemia/etiologia , Masculino , Hormônio Paratireóideo/sangue , Proteína Relacionada ao Hormônio Paratireóideo , Esquistossomose/complicações , Esquistossomose/diagnóstico , Vitamina D/sangueRESUMO
A Poodle referred for renal disease developed severe colonic disease characterized by total mucosal collapse and necrosis. The onset of colonic disease was temporally related to administration of antibiotics. On 3 occasions, bacterial culture of fecal samples yielded only Streptococcus pyogenes, Pseudomonas aeruginosa, and Candida albicans, suggesting that the colonic bacterial flora was severely disrupted. Findings, although not conclusive, were suggestive of antibiotic-associated colitis that ultimately proved fatal. Colonoscopy should be considered for dogs with unduly severe large-bowel diarrhea associated with antibiotic treatment and can be done with minimal restraint and bowel preparation, if necessary. Nonselective bacterial culture of fecal samples should be considered for dogs with unduly severe large-bowel diarrhea associated with antibiotic treatment.
Assuntos
Antibacterianos/efeitos adversos , Colite/veterinária , Diarreia/veterinária , Doenças do Cão/induzido quimicamente , Fluoroquinolonas , Hemorragia Gastrointestinal/veterinária , Ampicilina/efeitos adversos , Ampicilina/uso terapêutico , Animais , Antibacterianos/uso terapêutico , Anti-Infecciosos/efeitos adversos , Anti-Infecciosos/uso terapêutico , Colite/induzido quimicamente , Colo/patologia , Colonoscopia/veterinária , Diarreia/induzido quimicamente , Cães , Enrofloxacina , Evolução Fatal , Hemorragia Gastrointestinal/induzido quimicamente , Masculino , Quinolonas/efeitos adversos , Quinolonas/uso terapêuticoRESUMO
An 11-year-old, female domestic longhair was presented for dyspnea, vomiting, and left forelimb lameness. A mass in the left caudal lung lobe was seen on thoracic radiographs. The mass was resected during thoracotomy, and histopathology confirmed a diagnosis of endogenous lipid pneumonia. The cat recovered slowly from surgery and was euthanized 11 days following discharge because of persistent respiratory difficulties. Necropsy findings included lipid pneumonia and bronchogenic carcinoma, with probable tumor metastasis to the small intestine, spleen, kidney, and left triceps muscle.