Assuntos
Estrogênios/efeitos adversos , Menopausa/efeitos dos fármacos , Neoplasias Uterinas/induzido quimicamente , Adulto , Carcinógenos , Climatério/efeitos dos fármacos , Métodos Epidemiológicos , Estrogênios/uso terapêutico , Europa (Continente) , Feminino , Doenças dos Genitais Femininos/prevenção & controle , Humanos , Pessoa de Meia-Idade , Osteoporose/prevenção & controle , Progestinas/uso terapêutico , Risco , Estados Unidos , Neoplasias Uterinas/epidemiologiaRESUMO
The maternal serum concentrations of human chorionic gonadotropin, pregnancy-specific beta-l-glycoprotein, placental lactogen, progesterone, 17-hydroxyprogesterone, estradiol and estriol were measured in 13 women who smoked marijuana regularly throughout pregnancy. Cannabinoid use in these women was confirmed by RIA measurements of their serum delta 9-tetrahydrocannabinol (THC) concentrations. These THC using women were matched within 2 1/2 weeks of gestational age with 13 pregnant non-THC using controls drawn from the same population. Placental protein and steroid hormone concentrations were within established normal ranges for gestational age and there were no significant differences between the groups in the concentrations of any of the protein and steroids measured. In addition, no significant differences between THC users were found following linear regression analysis of placental hormone concentrations as a function of gestational age. Thus, this study suggests that marijuana use during pregnancy does not significantly alter the circulating maternal concentrations of trophoblastic protein hormones or major fetoplacental steroid hormones.
Assuntos
Cannabis , Proteínas da Gravidez/sangue , Gonadotropina Coriônica/sangue , Estradiol/sangue , Estriol/sangue , Feminino , Idade Gestacional , Humanos , Hidroxiprogesteronas/sangue , Lactogênio Placentário/sangue , Gravidez , Glicoproteínas beta 1 Específicas da Gravidez/análise , Progesterona/sangueRESUMO
The feasibility of using maternal serum human chorionic gonadotropin (hCG) concentrations for prenatal sex prediction was examined. hCG was mesured in 822 serum samples from 560 women with uncomplicated pregnancies. Significantly higher hCG concentrations were found in the serum of women bearing female fetuses than in the serum of women bearing male fetuses during the third trimester, especially during the 10th lunar month. The data were utilized to construct probability graphs for fetal sex prediction based upon a single maternal serum hCG determination during the third trimester and during the 10th lunar month. However, the utility of these graphs is limited by the small proportion of pregnant women with serum hCG concentrations that were high or low enough to allow a prediction with high probability.
