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J Pharmacol Exp Ther ; 183(1): 197-205, 1972 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-5080031

RESUMO

PIP: Norethynodrel metabolites in human plasma and urine were analyzed. Samples were collected from healthy young women over 1 24-hour period after the oral administration of 11.1 mg (50 mcCi) of 6, 7-tritiated norethynodrel. The 3 alpha-hydroxy compound from the reduction of the 3-ketone of norethynodrel was the major free metabolite in plasma, with lesser amounts of its 3 beta-isomer and norethindrone. These compounds were identified by carrier addition analysis and their concentrations were estimated by thin-layer radiochromatography. The bulk of plasma metabolites consisted of conjugates and greater than 95% of urinary metabolites (20% of total dose) were conjugated; 2 of which were beta-glucuronides. Enzymatic hydrolysis enabled the urinary compounds to be identified by gas-lizuid chromatography-mass spectrometry. 70-80% (10% of the dose) of the enzymatically hydrolyzed urinary metabolites were hydroxylated compounds. Triols were the principal hydroxylated compounds isolated. The metabolism of norethynodrel was rapid and extensive.^ieng


Assuntos
Noretinodrel/metabolismo , Adulto , Cromatografia Gasosa , Cromatografia em Camada Fina , Feminino , Humanos , Hidrólise , Hidroxilação , Cinética , Espectrometria de Massas , Noretinodrel/sangue , Noretinodrel/isolamento & purificação , Noretinodrel/urina , Trítio
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