Patients' perception about risks and benefits of antithrombotic treatment for the prevention of venous thromboembolism (VTE) after orthopedic surgery: a qualitative study.

BACKGROUND: The 9th edition of the American College of Chest Physicians' Antithrombotic Therapy and Prevention of Thrombosis guidelines emphasize the importance of considering the risk-benefit ratio of "patient-important" outcomes. However, little is known about patients' perception and understanding regarding the different outcomes of antithrombotic treatment after orthopedic surgery, and the factors that influence their decision to use these treatments. Using a series of semi-structured interviews, we explored patients' understanding and perception concerning the benefits and risks of antithrombotic treatment for the prevention of venous thromboembolism (VTE) after joint replacement surgery. METHODS: A series of semi-structured interviews were conducted with patients who had undergone knee or hip replacement surgery at a tertiary care hospital (Brigham and Women's Hospital, Boston, MA) in 2014. Discussions were recorded and transcribed. Two investigators independently coded and analyzed the data to identify important themes and concepts using the constant comparative method. RESULTS: Of 64 patients who were invited, 12 patients (19 %) completed the interviews. The majority of patients (92 %) were aware of the benefits of antithrombotic therapy for reducing the risk of blood clots, while less than half of them had a clear understanding of deep vein thrombosis and pulmonary embolism. While all patients were aware of risk of minor bleeding, only 6 patients (50 %) considered the risk of major bleeding as a possible side effect of antithrombotic treatment. Overall, patients perceived bleeding as a less important outcome than a thrombotic event. The lack of awareness about the risk of major bleeding, the assumption that a short-term exposure would not meaningfully affect bleeding risk, and the assumption that bleeding is a controllable event influenced their perception. Most patients (83 %) stated that their decision to use antithrombotic medications was mainly based on the trust in their physician's expertise. CONCLUSIONS: Patients perceived thrombotic events as more important outcomes than bleeding events. Patients' understanding of thrombotic and bleeding events varies and may play a key role in their preferences. The majority of patients stated that trust in their physician's expertise had a large influence on their decision to use antithrombotic medications.

The use of structural allograft for uncontained defects in revision total knee arthroplasty. A minimum five-year review.

BACKGROUND: To our knowledge, the medium to long-term outcome after revision knee arthroplasty with structural allograft augmentation for reconstruction of uncontained defects has not been determined. The purpose of the present study was to assess the outcome for patients managed with such a procedure. METHODS: We prospectively followed fifty patients who had fifty-two revision knee replacements with sixty-six structural grafts performed at three institutions. Twenty-nine knees (twenty-seven patients) were independently evaluated at a mean of 96.9 months (range, sixty to 189 months) by an investigator who had not been involved in the index procedure. Twelve knees (23%) had a repeat revision at a mean of 70.7 months (range, twenty-six to 157 months). The allograft was retained in two of these patients. Eleven patients died at a mean of ninety-three months (range, sixty-one to 128 months) after the procedure; the structural allograft and implants were intact, and the patients were not awaiting revision at the time of death. RESULTS: Clinical evaluation revealed that the mean modified Hospital for Special Surgery knee score had improved from 32.5 points preoperatively to 75.6 points at the time of the review and the mean range of motion had increased from 60.5 degrees preoperatively to 88.6 degrees. Failure was defined as an increase of less than 20 points in the modified Hospital for Special Surgery knee score at the time of the review or the need for an additional operation related to the allograft. Thirteen knee replacements failed, yielding a 75% success rate. Five knees had graft resorption, resulting in implant loosening. Four knee replacements failed because of infection, and two knees had nonunion between the host bone and the allograft. Two knees (one patient) did not have a 20-point improvement in the knee score. The survival rate of the allografts was 72% (95% confidence interval, 69% to 75%) at ten years. On radiographic analysis, none of the surviving grafts had severe resorption, one had moderate resorption, and two had mild resorption. One knee had a loose tibial component, and three knees had nonprogressive tibial radiolucent lines. All four knees were asymptomatic. CONCLUSIONS: Our results demonstrate that allografts used in revision knee replacement in patients with the difficult problem of massive bone loss have an encouraging medium-term rate of survival.

Reattachment of the migrated ununited greater trochanter after revision hip arthroplasty: the abductor slide technique. A review of four cases.

BACKGROUND: Proximal migration of the ununited greater trochanter following total hip arthroplasty may produce pain and substantial functional disability. Successful reattachment of the migrated fragment is difficult following multiple hip procedures. The purpose of this report is to describe four patients in whom a severely migrated trochanteric fragment was reattached successfully with a modified Charnley-Harris wiring technique after subperiosteal advancement of the abductor muscles from their origin on the iliac wing. METHODS: This series consisted of one man and three women with an average age of sixty years (range, fifty-one to sixty-eight years) at the time of the index procedure. The patients were followed for an average of eighty-one months (range, fifty-five to ninety-six months). All patients had undergone mobilization of the abductor muscles based on the superior gluteal neurovascular pedicle to aid with trochanteric reattachment, and all had undergone prior hip operations (average, two). Advancement of the abductor muscles was achieved through a separate transverse curvilinear incision over the iliac crest, and subperiosteal releases of the entire origins of the gluteus minimus, medius, and maximus muscles from the ilium were performed. RESULTS: Roentgenographic union of the trochanteric fragment occurred in all four patients. There were three excellent functional outcomes (Harris hip scores of 90, 94, and 96 points) and one fair functional outcome (76 points). The average improvement in the Harris hip score was 47.5 points (range, 35 to 58 points). Two patients continued to have a mild or moderate Trendelenburg gait postoperatively. Two patients had heterotopic bone formation of no clinical importance. CONCLUSIONS: Use of this technique resulted in union of the greater trochanter, pain relief, and decreased functional disability without major complications in these four patients. More widespread use of this technique may be indicated for the treatment of symptomatic non-union of the greater trochanter when the fragment cannot be reattached to its anatomical location with the hip in less than approximately 20 degrees of abduction.

Closed cervical spine trauma associated with bilateral vertebral artery injuries.

Bilateral vertebral artery injuries in closed cervical spine injuries are uncommon, but early recognition and treatment are important to prevent neurological deterioration. A case of bilateral vertebral injuries in a 35-year-old motor vehicle accident victim is presented, and the current literature is reviewed.

Revision total hip arthroplasty with correctional femoral osteotomy in Paget's disease.

Varus alignment of the femoral component is associated with femoral component loosening in total hip arthroplasty performed for Paget's disease. Irregular and hemorrhagic bone, along with angular femoral deformity, was encountered during revision total hip arthroplasty in three pagetic patients. A diaphyseal femoral osteotomy facilitated cement removal and provided an opportunity for correction of the deformity. The step-cut configuration of the osteotomy provided intrinsic rotational stability of the femoral segments around a modular, long-stem cementless implant. Excellent clinical and radiographic results were achieved, but moderate blood loss and delayed healing of the osteotomy site were observed.

Lumbar laminectomy alone or with instrumented or noninstrumented arthrodesis in degenerative lumbar spinal stenosis. Patient selection, costs, and surgical outcomes.

DESIGN: A prospective, multicenter observational study. OBJECTIVES: 1) Identify correlates of the decision to perform arthrodesis in patients undergoing laminectomy for lumbar spinal stenosis. 2) Compare symptoms, walking capacity, and satisfaction 6 and 24 months after laminectomy alone and laminectomy with noninstrumented and with instrumented arthrodesis. BACKGROUND DATA: Few prospective studies have compared outcomes of laminectomy alone or laminectomy with noninstrumented or with instrumented arthrodesis in patients with degenerative lumbar spinal stenosis. There is uncertainty regarding the optimal use of arthrodesis and instrumentation. METHODS: Two hundred seventy--two patients undergoing--surgery for degenerative lumbar stenosis by eight surgeons at four centers were included in the study cohort. Of these, 37 had noninstrumented and 41 had instrumented arthrodesis. Logistic regression identified factors associated with arthrodesis. The principal outcomes-health status, walking capacity, back and leg pain, and satisfaction with surgery-were assessed 6 and 24 months postoperatively with univariate and multivariate techniques. Outcomes also were assessed in a restricted cohort of patients with at least 5 mm spondylolisthesis and/or 15 degrees scoliosis. Hospital costs were obtained from a computerized hospital cost accounting system. RESULTS: The major predictor of the decision to perform arthrodesis was the individual surgeon (P = 0.0001). Noninstrumented arthrodesis was associated with superior relief of low back pain at 6 months (P = 0.004) and 24 months (P = 0.01). This difference persisted in multivariate analyses, with borderline statistical significance. There were no significant differences in the other outcomes across treatment groups. Mean hospital costs of laminectomy alone and noninstrumented and instrumented arthrodesis were $12,615, $18,495, and $25,914, respectively (P = 0.0001). CONCLUSION: Findings were limited by the small number of participating surgeons, modest sample size that produced P values of borderline significance, and nonrandomized design. With these caveats in mind, the authors conclude: (1) The individual surgeon was a more important correlate of the decision to perform arthrodesis than clinical variables such as spondylolisthesis. (2) Noninstrumented arthrodesis resulted in superior relief of back pain after 6 and 24 months. (3) Instrumented arthrodesis was the most costly option. These results highlight the need for randomized controlled trials and cost effectiveness analyses of lumbar arthrodesis and instrumentation in patients with degenerative lumbar spinal stenosis.

Supracondylar femoral fracture following total knee arthroplasty.

Twenty-nine supracondylar femoral fractures above total knee arthroplasty were studied retrospectively. Group 1 consisted of 5 nondisplaced fractures managed with closed treatment, yielding 5 satisfactory results. Group 2 consisted of 9 displaced fractures managed with closed treatment. There were no satisfactory results in Group 2; there were 8 malunions and 2 knees requiring revision. Group 3 consisted of 15 displaced fractures managed with open reduction and internal fixation. There were 10 satisfactory results in Group 3; there were 2 malunions and 3 knees requiring revision or repeat fixation. On the basis of these results, closed treatment for nondisplaced fractures is recommended. If displacement exists, early open reduction and internal fixation yields the greatest chance for a satisfactory result, though it has a significant complication rate.

Revision total knee arthroplasty after failed unicompartmental knee arthroplasty or high tibial osteotomy.

A retrospective matched-pair comparative analysis was done between 30 total knee arthroplasties following failed high tibial osteotomies and 30 total knee arthroplasties following failed unicompartmental knee arthroplasties. The groups were matched according to age, gender, type of prosthesis, primary disease, and length of followup. A minimum followup of 2 years was required for inclusion in the study, and the average followup was 3.8 years (range, 2-9 years). The Knee Society Knee Score for the high tibial osteotomy group was significantly higher than that for the unicompartmental arthroplasty group. More osseous reconstructions were required in the unicompartmental revisions. Difficulty with exposure was not significantly greater in the osteotomy group. Rates of component loosening were not significantly different between the groups. A failed unicompartmental knee arthroplasty and a failed high tibial osteotomy can be revised successfully to a total knee arthroplasty. The results confirm that revisions after unicondylar arthroplasty and high tibial osteotomy are technically demanding. In this series, the results of total knee arthroplasty following unicompartmental knee arthroplasty approached but did not equal those obtained after high tibial osteotomy.

Clinical correlates of patient satisfaction after laminectomy for degenerative lumbar spinal stenosis.

STUDY DESIGN: Prospective multicenter observational study of the outcome of surgery for degenerative lumbar spinal stenosis. OBJECTIVES: To identify correlates of patient satisfaction with the results of surgery. SUMMARY OF BACKGROUND DATA: Little published information exists on correlates of patient satisfaction after surgery for spinal stenosis. METHODS: Preoperative and 6-month follow-up data for 194 patients were analyzed. Associations between preoperative variables and satisfaction with the results of surgery were examined in univariate and multivariate models. RESULTS: In multiple linear regression models that adjusted for the effects of age, gender, individual surgeon, number of interspaces decompressed, whether a fusion was performed, depression score, and overall level of pain, the predominance of back (as opposed to leg) pain, greater comorbidity, and worse preoperative functional status were associated with lower patient satisfaction. The regression model explained just 15% of the variance in patient satisfaction. CONCLUSIONS: Patients bothered predominantly by back pain preoperatively and those with greater medical comorbidity and functional disability are significantly less satisfied with the results of surgery for degenerative lumbar spinal stenosis.

Technique and results of allograft reconstruction in revision total knee arthroplasty.

This study reports more than four years of experience with bone allografts used to reconstruct large uncontained defects in the femur and the tibia in patients requiring revision total knee arthroplasty. Nineteen allografts were used, 13 in the distal femur and six in the proximal tibia. The average follow-up period was 2.1 years. After these complex revision arthroplasties, the average knee score improved from 29 to 87 points. The average patient function score increased from 35 to 85 points. Bulk allografts are effective in the reconstruction of uncontained defects in revision total knee arthroplasty.

Radiographic detection of metal-induced synovitis as a complication of arthroplasty of the knee.

Radiographs of eighteen patients who had had a diagnosis of metal-induced synovitis subsequent to a knee-replacement arthroplasty were retrospectively reviewed. The presence of a dense line outlining a portion of the capsule or articular surface of the knee joint (the so-called metal-line sign) was noted in association with wear in eleven patients. In the nine patients who had a positive sign and also had specimens available for histological examination, there was dense deposition of metal particles, whereas in the six patients who did not have a metal-line sign and had specimens available for histological examination, five had only a slight amount of metal in the synovial tissue and one, a moderate amount. The presence of the metal-line sign was associated with metal-induced synovitis in eleven of the eighteen patients. The sign should be useful in helping to make this diagnosis preoperatively in many patients.

Blood supply to the patella. Significance in total knee arthroplasty.

Patellofemoral problems occur in approximately 5% of total knee arthroplasties and account for 50% of complications of total knee arthroplasty. Surgical disruption of the blood supply to the patella may cause an increase in the incidence of osteonecrosis, stress fracture, and loosening. The authors discuss patellar blood supply and surgical considerations in total knee arthroplasty and review the clinical experience with avascular patellae.

Long-term follow-up of cemented total hip replacement for osteoarthritis.

Two hundred twelve total hip replacements performed as a primary procedure have been followed for more than 10 years. One hundred thirty-six hips had adequate radiographic follow-up. Mechanical loosening of the acetabular and femoral component continue to be the major postoperative complications and in this series was 24 per cent. The incidence of femoral loosening has declined, however there is a continuing increase in acetabular revisions as well as an increase in bone-cement radiolucencies in relation to the acetabular component. Analysis of mechanical and technical parameters identifies those arthroplasties at increased risk of mechanical loosening, it is necessary to have two or more parameters of poor technique present before there is an increased incidence of loosening of the femoral component. Changes in stem design and cementing techniques in the early 1980s have addressed these parameters and in the mid-term have significantly decreased the incidence of mechanical failure. However we await the 10- to 15-year follow-up of these technical improvements to assess whether they will improve longevity of a biologic procedure. It is difficult to predict failure of cemented acetabular components and with longer follow-up there appears to be a steady increase in the incidence of acetabular loosening compared with a decrease in the occurrence of femoral loosening.

The effects of modern cementing techniques on the longevity of total hip arthroplasty.

Modern prosthetic design and cementing techniques have dramatically improved femoral component fixation. Compared to studies reported in the 1970s, the incidence of radiographic loosening for periods up to 5 years postoperatively has been reduced by at least a factor of 10. These results are the benchmark by which alternative forms of femoral component fixation must be measured. With the likelihood of increased longevity of total hip arthroplasty resulting from improved fixation, the problems of wear debris from the bearing surfaces and loss of bone stock with time will become preeminent.

The patellofemoral component of total knee arthroplasty.

Patellofemoral complications continue to form a large proportion (up to 50%) of total knee arthroplasty (TKA) complications. If adequate attention is paid intraoperatively to patellar tracking and component position, the incidence of subluxation, component loosening, and fracture should decrease. When treating patellar subluxation and dislocation, tibial tubercle transfer should be avoided because there is an unacceptably high incidence of complications. Care should be taken to treat the underlying cause of dislocation with either a soft tissue procedure or component revision. Fracture of the patella may be treated nonoperatively in 50% and 80% of patients. Cysts, if large, may be bone-grafted to avoid the potential complications of stress fracture and component loosening. Loosening of the patellar component is likely to be symptomatic and to require surgery in up to 75% of cases. A displaced patellar component may cause attritional wear of the quadriceps tendon or patellar ligament. All rheumatoid patellae should be resurfaced. The present trend in the osteoarthritic patella is toward resurfacing more often. With improved implant design and a predicted decrease in complications, resurfacing in the osteoarthritic patella may become routine. Osteoarthritic patellae that maintain good cartilage, normal anatomic shape, and congruent tracking need not be resurfaced.

Osteomyelitis of the odontoid process.

Pyogenic osteomyelitis of the odontoid process is a rare condition requiring a high index of suspicion for diagnosis. The three cases presented illustrate that patients with severe neck pain, aggravated by rotation, and persistent fever without apparent source should be studied carefully to exclude infection of the C1-C2 area. The unusual anatomy of the C1-C2 articulation may make routine diagnostic studies difficult to interpret. Computed tomography, magnetic resonance imaging, and 111In-labeled white blood cell scans may improve diagnostic accuracy. Treatment includes rigid immobilization, high dose antibiotics, and surgical stabilization in selected cases.

A comparison of Harrington rod fixation with and without segmental wires for unstable thoracolumbar injuries.

Between January 1, 1975 and November 1, 1986, 77 patients with acute unstable thoracic or lumbar spine fractures underwent reduction, posterior stabilization with dual Harrington distraction rods, and fusion with autogenous iliac crest bone graft at Vanderbilt University Medical Center. Beginning March 1985, in 25 patients, segmental interspinous wires were employed, in addition to the Harrington rods, to augment the surgical construct. Clinical and radiographic analysis was performed to determine if differences existed between the two groups. Average time to surgery, hospital stay, and time to brace discontinuance were lower in the segmental wire group. Pain and work status at final follow-up were similar in the two groups. There was a higher incidence of superior and inferior hook migration and reoperation for this complication in patients treated with Harrington rods alone. There was no significant difference in postoperative correction of deformity, although at follow-up, there was greater recurrence of deformity in the Harrington rod group. In summary, the use of segmental wires to supplement Harrington rod fixation appears to offer advantages over Harrington rods alone, with minimal or no increased risk.