Potential Use of DMSA-Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID-19 Disease.

Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID-19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with meso-2,3-dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid-state and are superparamagnetic at room temperature. There is no toxicity of SPIONS-DMSA under the cells of patients with COVID-19. Taken together the results show that DMSA- Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells.

In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles.

This article describes the synthesis, characterization and in vivo cytotoxic evaluation of thiol-functionalized superparamagnetic iron oxide magnetic nanoparticles (SPIONs). They have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. Fe3O4 nanoparticles were synthesized by coprecipitation of iron salts and coated with L-cysteine. The physicochemical, morphological, and magnetic properties of Cys-Fe3O4 nanoparticles were characterized by different experimental techniques. To evaluate their applicability in nanomedicine we evaluated their cytotoxicity using Balb/C mice. The results show that Cys-SPIONs are good candidates as nanocarriers in biomedical applications.