[Comparison of clinical efficacy of trental various routes administration in hypoxic states of eye posterior segment]. / Sravnenie klinicheskoi éffektivnosti razlichnykh putei vvedeniia trentala pri gipoksicheskikh sostoianii zadnego otrezka glaza.

Ninety-four patients with acute and chronic diseases of the posterior segment of the eye (optic nerve atrophy, central chorioretinal dystrophy, ischemic neuropathy, circulatory disorders in the central retinal artery and its branches) were examined. Clinical efficacy of various routes of administration of trental (intravenous, parabulbar, and by subtenon implantation of a collagen infusion system--SICIS) was evaluated in patients with ischemic states of the posterior segment of the eye. The most pronounced improvement of visual acuity was observed after administration through collagen infusion system. In acute and chronic hypoxic diseases of the posterior segment of the eye the time course of the rheographic coefficient was virtually the same after intravenous and parabulbar administration, while after SICIS the rheographic coefficient was significantly higher. Therefore, SICIS is the most effective method for trental administration in patients with acute and chronic diseases of the posterior segment of the eye; parabulbar administration ranks second in efficiency. This recommends SICIS as the most effective method for trental administration.

[Extracellular glycoproteins of the ocular trabecular zone in patients with primary open-angle glaucoma]. / Ekstrakletochnye glikoproteiny trabekuliarnoi zony glaz bol'nykh pervichnoi otkrytougol'noi glaukomoi.

The content of fibronectin, an extracellular glycoprotein, in the drainage out-flow system of human eyes was measured by the indirect immunoperoxidase staining technique. The degree of fibronectin accumulation in ocular tissues was evaluated by quantitative morphometric analysis. Fibronectin level in the ocular drainage system of humans grows with ageing and rapidly increases at different stages of primary open-angle glaucoma development. Increased deposit of fibronectin in trabecular tissue, mainly in the inner wall of Schlemm's canal and juxtacanalicular or cribriform part of trabecular meshwork, was demonstrated. A hypothesis explaining the development of the glaucomatous process by an adhesive impairment is proposed.

[Age-related changes in fibronectin of the eye outflow drainage system]. / Vozrastnaia dinamika fibronektina drenazhnogo apparata glaza.

The content of the fibronectin, an extracellular glycoprotein in the drainage outflow system of human eyes was determined by the indirect immunoperoxidase staining technique. The degree of fibronectin accumulation in ocular tissues was evaluated by quantitative morphometric analysis. It was shown that the fibronectin level was elevated in ageing. Increased deposit of fibronectin in trabecular tissues, mainly, in the inner wall of Schlemm's canal and juxta-canalicular zone was demonstrated along with ageing. Comparison of fibronectin accumulation in glaucoma and ageing support the idea that ageing is a risk factor of glaucoma.