RESUMO
The uptake and localisation of O-(beta-hydroxyethyl)-rutosides (HR) in the venous wall was studied in 8 patients undergoing crossectomy for a varicose long saphenous vein. The fluorescence of cross-sections of the vein wall was measured by laser scanning microscopy, based on the autofluorescence of HR. Four patients (treated group) received 2 x 1.5 g HR IV before surgery, and four (untreated patients) served as controls. Uptake of HR into the veins from treated patients was seen, with a mean fluorescence intensity of 80.9 units compared to 49.4 units in the untreated veins. The increase in fluorescence was clearly demarcated on the endothelial side of the vein wall. It is concluded that HR passes into the vascular wall, where it is localised in the endothelial and sub-endothelial areas.
Assuntos
Anticoagulantes/metabolismo , Hidroxietilrutosídeo/análogos & derivados , Veia Safena/metabolismo , Adulto , Anticoagulantes/administração & dosagem , Humanos , Hidroxietilrutosídeo/administração & dosagem , Hidroxietilrutosídeo/farmacocinética , Lasers , Microscopia de Fluorescência , Pessoa de Meia-Idade , Veia Safena/cirurgia , Varizes/cirurgiaRESUMO
Usual techniques in open-heart operations leave a vertical median skin scar. Especially for women this is rather embarassing since it looks ugly. The use of horizontal submammary skin incision for access to the heart is described here. Although obtaining the usual midsternal exposure takes some extra time, long-term results have shown the value of this approach and its benefit to the patient. The surgical technique is simple, and wound healing, in the long run, is unimpaired.
