RESUMO
OBJECTIVE: Reducing time-to-treatment and providing acute management in stroke are essential for patient recovery. Electrical bioimpedance (EBI) is an inexpensive and non-invasive tissue measurement approach that has the potential to provide novel continuous intracranial monitoring-something not possible in current standard-of-care. While extensive previous work has evaluated the feasibility of EBI in diagnosing stroke, high-impedance anatomical features in the head have limited clinical translation. METHODS: The present study introduces novel electrode placements near highly-conductive cerebral spinal fluid (CSF) pathways to enhance electrical current penetration through the skull and increase detection accuracy of neurologic damage. Simulations were conducted on a realistic finite element model (FEM). Novel electrode placements at the tear ducts, soft palate and base of neck were evaluated. Classification accuracy was assessed in the presence of signal noise, patient variability, and electrode positioning. RESULTS: Algorithms were developed to successfully determine stroke etiology, location, and size relative to impedance measurements from a baseline scan. Novel electrode placements significantly increased stroke classification accuracy at various levels of signal noise (e.g., p < 0.001 at 40 dB). Novel electrodes also amplified current penetration, with up to 30% increase in current density and 57% increased sensitivity in central intracranial regions (p < 0.001). CONCLUSION: These findings support the use of novel electrode placements in EBI to overcome prior limitations, indicating a potential approach to increasing the technology's clinical utility in stroke identification. SIGNIFICANCE: A non-invasive EBI monitor for stroke could provide essential timely intervention and care of stroke patients.