RESUMO
Long-term use of proton pump inhibitors can lead to serious hypomagnesaemia. Intestinal magnesium absorption takes place by passive paracellular and active transcellular transport. It has been hypothesized that proton pump inhibitors impair the active transcellular magnesium transport. The resulting hypomagnesaemia may cause hypoparathyroidism, hypocalcaemia and hypokalaemia. Proton pump inhibitor-induced hypomagnesaemia is reversible: it resolves when proton pump inhibitors are stopped. The indication for long-term proton pump inhibitor treatment should be evaluated periodically.
Assuntos
Absorção Intestinal/efeitos dos fármacos , Deficiência de Magnésio/induzido quimicamente , Magnésio/sangue , Magnésio/farmacocinética , Inibidores da Bomba de Prótons/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Antiulcerosos/efeitos adversos , Antiulcerosos/uso terapêutico , Feminino , Humanos , Hipocalcemia/induzido quimicamente , Hipocalcemia/etiologia , Hipopotassemia/induzido quimicamente , Hipopotassemia/etiologia , Hipoparatireoidismo/induzido quimicamente , Hipoparatireoidismo/etiologia , Deficiência de Magnésio/complicações , Masculino , Pessoa de Meia-Idade , Omeprazol/efeitos adversos , Omeprazol/uso terapêutico , Úlcera Gástrica/tratamento farmacológicoRESUMO
In this case report we describe 2 patients with acute leukaemia, a 38-year-old and a 21-year-old woman who were both admitted to the intensive care unit (ICU) twice for different complications of underlying disease and chemotherapy. Although the survival rates for patients with haematological malignancies requiring admission to intensive care have increased in the last two decades, many physicians are still reluctant to admit these patients to intensive care. However, 50% of these patients are successfully discharged from intensive care, regardless of age or underlying haematological disease. The length of stay in the ICU does not correlate with mortality in the ICU either. Intensive mechanical ventilation and multiple organ failure increase mortality in patients with haematological malignancies undergoing intensive treatment in an ICU.