1.
Bioorg Med Chem Lett
; 15(3): 625-9, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15664826
RESUMO
Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests.