RESUMO
1-Benzylbenzimidazole reacts with chloromethylalkyl ethers or sulfides or chloromethylcycloalkyl ethers to produce 3-alkoxymethyl-1-benzylbenzimidazolium or 3-alkylthiomethyl-1-benzylbenzimidazolium or 1-benzyl-3-cycloalkoxymethylbenzimidazolium chlorides in very good yields. All the 1-benzylbenimidazolium chlorides showed antimicrobial activity. The relationship between chemical structure and antimicrobial activity was analyzed by quantitative structure-activity relationships (QSAR).
Assuntos
Anti-Infecciosos/síntese química , Anti-Infecciosos/farmacologia , Benzimidazóis/síntese química , Benzimidazóis/farmacologia , Anti-Infecciosos/química , Benzimidazóis/química , Cloretos/síntese química , Cloretos/química , Cloretos/farmacologia , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Relação Estrutura-AtividadeRESUMO
Decyldimethylamine reacts readily with chloromethylalkyl ethers of sulfides, chloromethylbenzyl ethers or sulfides and chloromethylcycloalkyl ethers to give quaternary ammonium chlorides in very good yields. All the chlorides studied showed antimicrobial activity. The relationship between the chemical structure and antimicrobial activity was analyzed by rough sets.
