[Polish multicenter study on safety and efficacy of adefovir dipivoxil in the treatment of lamivudine resistant chronic hepatitis B in adults (HEP 2008)]. / Wieloosrodkowe badanie bezpieczenstwa i skutecznosci preparatu dipiwoksyl adefowiru w leczeniu przewleklego wirusowego zapalenia watroby typu B u doroslych z opornoscia na lamiwudyne (HEP 2008).

Initiated in April 2008 Polish multicenter study HEP2008 aimed clinical data concerning safety and efficacy of adefovir dipivoxil (ADV, Hepsera, Gilead Sciences) in adult chronically infected HBV with lamivudine (LAM) resistance after earliest treatment. We examined 38 men (70.4%) and 16 women (29.6%) with chronic hepatitis B in age 23-81 (average 53) mostly HBeAg positive (70.4%). Majority of patients received earlier LAM (72%), but others additional entekawir and\ or pegylated interferon. Average time from discovering infection HBV was 95 +/- 77 (10-307) months. Majority of patients received monotherapy ADV, but physicians decided at 12 (22%) persons about continuation of LAM therapy. Median HBV DNA level decreased from a baseline value 6.73 +/- 1.71 (1.8-9.0) to 3.25 log10 copies/mL. At least HBV DNA drop 1 log10 and 2 log10 get 78.8 and 60.6% in 24 week, 84.8 and 69.7% in 48 week. HBV DNA reduction below level 300 and 50 copies/mL it observed in 15.2 and 6.1% in 24 week, 39.4 and 30.3% in 48 week. Patients with undetectable Mean ALT activity dropped significantly and were below limit norm at 24 week in 40%, and at 48 week in 58% of patients. Patients treated ADV and LAM reached great reduction of ALT activity but was no influence on HBV DNA reduction. Results of research have confirmed efficiency and safety 48-week's therapy ADV in patients with LAM resistance.

[A case of haemorrhagic fever with renal syndrome (HFRS)]. / Przypadek goraczki krwotocznej z zespolem nerkowym (HFRS).

In our article we describe clinical and epidemiological analysis of the first case of haemorrhagic fever with renal syndrome (HFRS)--with serological confirmation--in Poland.

[Human granulocytic ehrlichiosis co-incident with Lyme borreliosis in pregnant woman--a case study]. / Ludzka erlichioza granulocytarna wspólistniejaca z borelioza z Lyme u kobiety ciezarnej.

A case of 25 years old woman, living in an endemic area for Lyme borreliosis was examined. In 29 th week of pregnancy thrombocytopenia, fever and fatigue were observed, in the last 7 weeks erythema migrans was present. The woman was not treated by that time. The infant presented thrombocytopenia in the first few weeks of life. 3 months after delivery erythema migrans disseminata was observed, by that time Lyme borreliosis and HGE were serologically confirmed. It was not confirmed that the infection was transferred to the infant, but it is possible that thrombocytopenia was caused by the infection with A. phagocytophila.

[Visceral leishmaniasis as a rare cause of a fever of unknown origin associated with splenomegaly]. / Leiszmanioza trzewna jako rzadka przyczyna goraczki nieznanego pochodzenia z towarzyszaca splenomegalia.

We present a case of a 22-year-old man admitted to the hospital because of prolonged fever associated with splenomegaly. During the previous 2 years the patient spent several months as a manual worker in the south of Italy. Manifestations of the disease included progressive weight loss, hyperhydrosis, biphasic fever, marked splenomegaly and slightly enlarged liver. Results of laboratory examination showed thrombocytopenia, leukopenia, hypergammaglobulinemia and features of hepatic lesions. A bone marrow biopsy revealed amastogotes of Leishmania within macrophages and in the extracellular matrix. A diagnosis of visceral leishmaniasis was confirmed by positive serological tests for Leishmania infantum antigens.