RESUMO
The Diego locus had been shown to be genetically distinct from the loci for all the established blood group systems save that for Lutheran. This gap has now been filled, after 21 years, by studies of a Cree Indian family which demonstrates that Diego is separate also from the Lutheran locus.
Assuntos
Antígenos de Grupos Sanguíneos , Adulto , Feminino , Genótipo , Humanos , Indígenas Norte-Americanos , Recém-Nascido , Isoanticorpos/análise , GravidezRESUMO
Anti-Fy3, found in the serum of an Fy(a-b-) Cree Indian woman believed to have been transfused 5 years previously, caused moderate hemolytic disease of the newborn in her eighth live-born baby. Only three examples of anti-Fy3 are know. It is striking that two were made by non-negro people, amongst whom Fy(a-b-) is extremely rare, and only one by a Negro, in whose people Fy(a-b-) is by far the commonest phenotype. This suggests that Fy(a-b-) may be a heterogeneous phenotype, with the negro version conferring some impediment to immunization by Fya, Fyb or Fy3 antigens. The rare allele Fyx is also present in the kindred of the propositus, and is shown to correspond to weak Fy3 as well as weak Fyb anitgen.
Assuntos
Anticorpos , Antígenos de Grupos Sanguíneos , Sistema do Grupo Sanguíneo Duffy , Indígenas Norte-Americanos , Alberta , Consanguinidade , Feminino , Genótipo , Humanos , Masculino , Linhagem , Gravidez , SorotipagemAssuntos
Eritroblastose Fetal/prevenção & controle , Imunoglobulina G/administração & dosagem , Sistema do Grupo Sanguíneo Rh-Hr , Adolescente , Adulto , Parto Obstétrico , Feminino , Humanos , Imunidade Materno-Adquirida , Recém-Nascido , Isoanticorpos/análise , Masculino , Troca Materno-Fetal , GravidezRESUMO
A study of the incidence of Rh-sensitization showed a 6.5% incidence of anti-D appearing for the first time during the last trimester of pregnancy. In 24 of the 29 subjects these antibodies were weak, and were found only when a sensitive technique using enzyme-treated Rh-deletion test cells was employed. The remaining five, however, had high-titre antibodies, which were associated with a positive Coombs test on cord blood.Rh-immune globulin administered at delivery resulted in disappearance of the anti-D in all but one of the subjects with weak antibody to whom it was given, suggesting that this treatment can reverse early sensitization. There was no effect when Rh-immune globulin was given to one subject with a high anti-D titre.Since sensitization has been found to occur frequently during the last trimester of pregnancy, an antenatal schedule of prophylaxis is advocated.