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1.
Food Nutr Res ; 672023.
Artigo em Inglês | MEDLINE | ID: mdl-38084146

RESUMO

Trivalent chromium (CrIII) is the principal form of chromium found in diet and supplements. CrIII has been claimed to be involved in the regulation of carbohydrate, lipid, and protein metabolism. Hexavalent chromium (CrVI) is a carcinogen when inhaled, which is uncommon, and occurs mainly by occupational exposures. There is a concern about adverse health effects also from exposure to CrVI by contaminated drinking water, although data from human studies are limited. Chromium had no recommendation in the Nordic Nutrition Recommendations (NNR) 2012 and the European Food Safety Authority (EFSA) did not set any reference values either. Methods for evaluating chromium status are lacking, and there is still uncertainty about how chromium deficiency in humans manifests itself. The essentiality of chromium is also disputed. This scoping review revealed new research activity relating to high-dose chromium supplements and several health outcomes (overweight, obesity, and diabetes). Although these issues are related to health concerns in the Nordic or Baltic countries, the relevance for the NNR is modest, since such a high intake of chromium cannot be achieved by diet. Thus, no strong evidence was identified in the scientific literature that justifies a recommendation for chromium intake.

2.
J Agric Food Chem ; 70(11): 3391-3399, 2022 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-35263104

RESUMO

The stable nitrogen isotope ratio δ15N is used as a marker of dietary protein sources in blood. Crop fertilization strategies affect δ15N in plant foods. In a double-blinded randomized cross-over dietary intervention trial with 33 participants, we quantified the effect of fertilizer type (conventional: synthetic fertilizer and organic: animal or green manure) on δ15N in blood plasma. At study baseline, plasma δ15N was +9.34 ± 0.29‰ (mean ± standard deviation). After 12 days intervention with a diet based on crops fertilized with animal manure, plasma δ15N was shifted by +0.27 ± 0.04‰ (mean ± standard error) compared to synthetic fertilization and by +0.22 ± 0.04‰ compared to fertilization with green manure (both p < 0.0001). Accordingly, differences in the δ15N values between fertilizers are propagated to the blood plasma of human consumers. The results indicate a need to consider agricultural practices when using δ15N as a dietary biomarker.


Assuntos
Fertilizantes , Nitrogênio , Agricultura/métodos , Animais , Humanos , Esterco/análise , Nitrogênio/análise , Isótopos de Nitrogênio/análise
3.
Artigo em Inglês | MEDLINE | ID: mdl-36612999

RESUMO

Diets influence our mental health and social wellbeing (MHSW) in multiple ways. A rising community concept, Eco-Regions, has gained interest. The research project "Indicators for assessment of health effects of consumption of sustainable, organic school meals in Ecoregions" (INSUM) aims to develop future-oriented research approaches to measure the potential health effects of more sustainable and healthy diets. This first part of the project focuses on MHSW with the goal to identify suitable study designs and indicators. The methodology is based on a 2-day workshop with an interdisciplinary group of experts. This paper describes commonly applied research methods on the nexus between diet and MHSW as presented by the experts and summarises key points from the discussions. The results show that the dominating tool to investigate MSHW is questionnaires. Questionnaires vary largely depending on the research design, such as participants or distribution channels. Cohort studies addressing families and including in-depth interventional and/or experimental studies may be suitable for an Eco-Region investigation. Those MHSW studies can be conducted and combined with measurements of somatic health effects. We conclude that indicators should be seen as complementary rather than independent. Explorative research designs are required to investigate complex Eco-Regions.


Assuntos
Dieta , Saúde Mental , Humanos , Dieta Saudável , Estudos de Coortes
4.
Foods ; 10(7)2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34359429

RESUMO

Meat is highly nutritious and contributes with several essential nutrients which are difficult to obtain in the right amounts from other food sources. Industrially processed meat contains preservatives including salts, possibly exerting negative effects on health. During maturation, some processed meat products develop a specific microbiota, forming probiotic metabolites with physiological and biological effects yet unidentified, while the concentration of nutrients also increases. Meat is a source of saturated fatty acids, and current WHO nutrition recommendations advise limiting saturated fat to less than ten percent of total energy consumption. Recent meta-analyses of both observational and randomized controlled trials do not support any effect of saturated fat on cardiovascular disease or diabetes. The current evidence regarding the effect of meat consumption on health is potentially confounded, and there is a need for sufficiently powered high-quality trials assessing the health effects of meat consumption. Future studies should include biomarkers of meat intake, identify metabolic pathways and include detailed study of fermented and other processed meats and their potential of increasing nutrient availability and metabolic effects of compounds.

5.
Clin Nutr ESPEN ; 43: 137-147, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34024505

RESUMO

BACKGROUND AND AIMS: Meals-on-wheels in nursing homes are sensory diminished because of the packaging and reheating of the food, which creates less appetite stimulation and an impaired meal experience for nursing home residents. This background is crucial since nursing home residents are a frail and often malnourished group that is physiologically affected by sensory, physical and mental alterations. The study aimed to increase health-related quality of life in nursing home residents receiving meals-on-wheels using an intervention menu with favourite meals that added a culinary twist and were sensory improved by chefs. METHODS: A double-blinded cluster-randomized controlled trial with two arms, one group receives an intervention menu, and the other group receives a non-optimized menu. The intervention menu included popular meals-on-wheels (a main meal for dinner and a starter/dessert before or after dinner with culinary improvements). The participants received the same meals without culinary improvements in the control group. Health-related quality of life (EQ5D3L) was the primary outcome of the study. Secondary outcomes were mental and nutritional status and muscle strength. The measurements were assessed at a baseline and end visit (12 weeks after baseline visit). RESULTS: Fifty-two nursing home residents were included in the study (There are 20 in the intervention group and 32 in the control group). Following the principle of intention-to-treat, a significant decreasing effect (p-value 0.026) was found between the groups on health-related quality of life. The treated group experienced the largest decrease from the baseline to the end visit. The intervention group had a significant decrease in the second item on Satisfaction With Food-related Life (SWFL2) (I am very pleased with my food). No changes were found either within or between the groups, on the rest of the measured parameters. CONCLUSIONS: Nursing home residents are a target group experiencing natural aggravation, why the health-related quality of life might be difficult to improve using a culinary meal intervention. The decreasing effect of Satisfaction With Food-related Life found in the intervention group could be related to these older adults being too unfamiliar with the culinary twist added to the intervention menu. The study was registered on ClinTrials.gov (Identifier NCT03133364).


Assuntos
Serviços de Alimentação , Qualidade de Vida , Idoso , Humanos , Refeições , Casas de Saúde , Estado Nutricional
6.
Br J Nutr ; 124(12): 1338-1344, 2020 12 28.
Artigo em Inglês | MEDLINE | ID: mdl-32624024

RESUMO

Identifying a need for developing a conceptual framework for the future development of Food-Based Dietary Guidelines (FBDG) in Europe, The Federation of European Nutrition Sciences established a Task Force for this purpose. A workshop was held with the specific objective to discuss the various dimensions considered as particularly relevant. Existing frameworks for FBDG were discussed, and presentations from various countries illustrated not only several commonalities but also a high degree of heterogeneity in the guidelines from different countries. Environmental aspects were considered in several countries, and dimensions like food safety, dietary habits and preparation were included in others. The workshop provided an overview of the use of FBDG - both in developing front-of-pack nutrition labels and for reformulation and innovation. The European FBDG dimensions were described with examples from the close connection between FBDG and European Union (EU) policies and activities and from the compilation of a database of national FBDG. Also, the challenges with communication of FBDG were discussed. Considering the current scientific basis and the experiences from several countries, the Task Force discussed the various dimensions of developing FBDG and concluded that environmental aspects should be included in the future conceptual framework for FBDG. A change in terminology to sustainable FDBG (SFBDG) could reflect this. The Task Force concluded that further work needs to be done exploring current practice, existing methodologies and the future prospects for incorporating other relevant dimensions into a future Federation of European Nutrition Societies conceptual framework for SFBDG in Europe and working groups were formed to address that.


Assuntos
Dietética/tendências , Previsões , Política Nutricional , Comitês Consultivos , Dinamarca , Educação , Europa (Continente) , Humanos , Sociedades Médicas
7.
Obesity (Silver Spring) ; 28(1): 73-79, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31858737

RESUMO

Emissions of greenhouse gases (GHG) are linked to global warming and adverse climate changes. Meeting the needs of the increasing number of people on the planet presents a challenge for reducing total GHG burden. A further challenge may be the size of the average person on the planet and the increasing number of people with excess body weight. We used data on GHG emissions from various sources and estimated that obesity is associated with ~20% greater GHG emissions compared with the normal-weight state. On a global scale, obesity contributes to an extra GHG emissions of ~49 megatons per year of CO2 equivalent (CO2 eq) from oxidative metabolism due to greater metabolic demands, ~361 megatons per year of CO2 eq from food production processes due to increased food intake, and ~290 megatons per year of CO2 eq from automobile and air transportation due to greater body weight. Therefore, the total impact of obesity may be extra emissions of ~700 megatons per year of CO2 eq, which is about 1.6% of worldwide GHG emissions. Inasmuch as obesity is an important contributor to global GHG burden, strategies to reduce its prevalence should prioritize efforts to reduce GHG emissions. Accordingly, reducing obesity may have considerable benefits for both public health and the environment.


Assuntos
Exposição Ambiental/efeitos adversos , Gases de Efeito Estufa/efeitos adversos , Obesidade/etiologia , Material Particulado/efeitos adversos , Emissões de Veículos/toxicidade , Dióxido de Carbono/efeitos adversos , Dióxido de Carbono/metabolismo , Planejamento Ambiental , Exposição Ambiental/estatística & dados numéricos , Humanos , Desintoxicação Metabólica Fase I/fisiologia , Obesidade/epidemiologia , Obesidade/metabolismo , Estresse Oxidativo/fisiologia , Características de Residência , Fatores de Risco , Meio Social
8.
Adv Nutr ; 11(1): 1-9, 2020 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-31504086

RESUMO

Current dietary guidelines advocate more plant-based, sustainable diets on the basis of scientific evidence about diet-health relations but also to address environmental concerns. Here, we critically review the effects of plant-based diets on the prevalence of obesity and other health outcomes. Plant-based diets per se have limited efficacy for the prevention and treatment of obesity, but most have beneficial effects in terms of chronic disease risk. However, with the considerable possibilities of translating plant-based diets into various types of dietary patterns, our analysis suggests that potential adverse health effects should also be considered in relation to vulnerable groups of the population. A transition to more plant-based diets may exert beneficial effects on the environment, but is unlikely to affect obesity, and may also have adverse health effects if this change is made without careful consideration of the nutritional needs of the individual relative to the adequacy of the dietary intake.


Assuntos
Doença Crônica/prevenção & controle , Mudança Climática , Dieta Vegetariana , Comportamento Alimentar , Abastecimento de Alimentos , Obesidade/prevenção & controle , Plantas , Dieta , Dieta Vegetariana/efeitos adversos , Meio Ambiente , Humanos , Política Nutricional , Necessidades Nutricionais
9.
Int J Obes (Lond) ; 43(2): 219-232, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-29980762

RESUMO

Overweight and obesity are highly prevalent throughout the world and can adversely affect the nutritional status of individuals. Studies have shown that many people with obesity have inadequate intake of iron, calcium, magnesium, zinc, copper, folate and vitamins A and B12, likely as a result of poor diet quality. Nutritional inadequacies or deficiencies may also occur due to altered pharmacokinetics in the individual with obesity and due to interactions in those with overweight or obesity with various pharmaceuticals. However, it has been demonstrated that the adult population in the United States as a whole is deficient in certain micronutrients as a result of the availability and overconsumption of high-calorie, low-nutrient processed foods. Poor nutrition may contribute to the development of certain chronic conditions, such as type 2 diabetes, which is already more prevalent in those with obesity. Clinicians need to be aware of these gaps, particularly in those individuals with obesity who are undergoing bariatric surgery or taking pharmaceutical products long term to facilitate weight loss. Patients with overweight or obesity likely struggle to achieve a balanced diet and may benefit from consultation with a dietitian. Along with providing recommendations for healthy eating and exercise, supplementation with specific micronutrients or multivitamins should be considered for individuals at the highest risk for or with established deficiencies. Further research is needed to understand the factors underlying nutritional inadequacies in individuals with overweight or obesity, as well as the outcomes of treatment strategies employed to address them.


Assuntos
Estado Nutricional , Obesidade , Sobrepeso , Dieta , Humanos , Micronutrientes , Distúrbios Nutricionais
10.
Nutr Metab (Lond) ; 15: 24, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29643928

RESUMO

BACKGROUND: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12, D and E status and the degree of inflammation. METHODS: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2, completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED. RESULTS: At baseline, 8% of the participants were deficient in folate, 13% in vitamin B12, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [- 13.1,-11.6] kg. The serum concentration of folate, vitamin B12 and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001). CONCLUSION: Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B12 and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation. TRIAL REGISTRATION: Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131.

11.
Int J Sport Nutr Exerc Metab ; 27(5): 399-407, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28556690

RESUMO

Impaired muscle function has been coupled to vitamin D insufficiency in young women and in elderly men and women. Those living at Northern latitudes are at risk for vitamin D insufficiency due to low sun exposure which may be more pronounced among elite swimmers because of their indoor training schedules. We aimed to examine vitamin D status among young elite swimmers and evaluate the association between vitamin D status and muscle strength. Twenty-nine swimmers, 12 female and 17 male (16-24 years) residing at latitude 55-56°N were studied in March and April. Blood samples were analyzed for serum 25-hydroxyvitamin D (s-25(OH)D) and hand-grip strength was measured as marker of muscle strength. Subjects´ vitamin D and calcium intake were assessed by food frequency questionnaire and sun exposure and training status by questionnaires. Mean (± SD) s-25(OH)D was 52.6 ± 18.3nmol/L among all swimmers. In 45% of the swimmers s-25(OH)D was below 50 nmol/L. Female swimmers had higher s-25(OH)D concentration than male swimmers (61.7 ± 17,5 nmol/L vs. 46.2 ± 16,5 nmol/L, p = .026). Among male swimmers, those with sufficient vitamin D status had higher hand grip strength than those with insufficient vitamin D status (50.6 ± 6.4 kg vs. 41.1 ± 7.8 kg, p = .02). Among Danish elite swimmers 45% had an insufficient vitamin D status during the spring; the prevalence being higher among male swimmers. Muscle strength was significantly higher in male swimmers with sufficient vitamin D status.


Assuntos
Força da Mão , Fenômenos Fisiológicos da Nutrição Esportiva , Natação/fisiologia , Vitamina D/análogos & derivados , Adolescente , Adulto , Atletas , Dinamarca , Feminino , Humanos , Masculino , Estações do Ano , Inquéritos e Questionários , Vitamina D/sangue , Adulto Jovem
12.
Curr Dev Nutr ; 1(8): e000430, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29955714

RESUMO

Background: The National Nutrition Research Roadmap has called for support of greater collaborative, interdisciplinary research for multiple areas of nutrition research. However, a substantial reduction in federal funding makes responding to these calls challenging. Objectives: The objectives of this study were to examine temporal trends in research funding and to discuss the potential consequences of these trends. Methods: We searched the NIH RePORTER database to identify NIH research grants and USASpending to identify National Science Foundation and USDA research grants awarded from 1992 to 2015. We focused on those that pertained to vitamin research. For the years 2000 to 2015, we examined funding trends for different vitamins, including vitamins A, B (one-carbon B-vitamins were considered separately from other B-vitamins), C, D, E, and K. Results: From 1992 to 2015, total federal research spending increased from ∼$14 to $45 billion (2016 US dollars). Although vitamin research spending increased from ∼$89 to $95 million, the proportion of grants awarded for vitamin research declined by more than two-thirds, from 0.65% in 1992 to 0.2% in 2015. Federal agencies awarded 6035 vitamin research grants over the time period, with vitamin A associated with the most research projects per year on average (n = 115) and vitamin K the fewest (n = 8). Vitamin D research projects were associated with the greatest average yearly project value ($34.8 million). Conclusions: Vitamin research has faced a disproportionate decline in research funding from 1992 to 2015. Insufficient federal research funding streams risk stalling progress in vitamin research and leaving important advancements unrealized.

13.
Nutrients ; 10(1)2017 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-29295513

RESUMO

Dietary intake of vitamin D includes vitamin D3 (vitD3), 25-hydroxyvitamin D3 (25OH-D3), and vitamin D2 (vitD2). However, the bioactivity of the different species has not been scientifically established. The hypothesis in this study was that vitD3, 25OH-D3, and vitD2 have an equal effect on 25-hydroxyvitamin D in serum (vitamin D status). To test our hypothesis, we performed a randomized, crossover study. Twelve young males consumed 10 µg/day vitD3 during a four-week run-in period, followed by 3 × 6 weeks of 10 µg/day vitD3, 10 µg/day 25OH-D3, and 10 µg/day vitD2. The content of vitD3, vitD2, 25OH-D3, and 25-hydroxyvitamin D2 (25OH-D2) in serum was quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The hypothesis that the three sources of vitamin D affect vitamin D status equally was rejected. Based on the assumption that 1 µg vitD3/day will show an increase in vitamin D status of 1.96 nmol/L, the results showed that 23 µg vitD2 and 6.8 µg 25OH-D3 was similar to 10 µg vitD3. These results demonstrate that further investigations are necessary to determine how to quantify the total vitamin D activity based on chemical quantification of the individual vitamin D metabolites to replace the total vitamin D activity assessed in biological rat models.


Assuntos
Calcifediol/administração & dosagem , Suplementos Nutricionais , Ergocalciferóis/administração & dosagem , Estado Nutricional , Vitamina D/análogos & derivados , Vitaminas/administração & dosagem , Adulto , Biomarcadores/sangue , Cromatografia Líquida , Estudos Cross-Over , Dinamarca , Método Duplo-Cego , Voluntários Saudáveis , Humanos , Masculino , Avaliação Nutricional , Espectrometria de Massas em Tandem , Fatores de Tempo , Vitamina D/sangue , Adulto Jovem
14.
Am J Clin Nutr ; 101(6): 1188-96, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25926507

RESUMO

BACKGROUND: Probiotics can modulate the immune system in healthy individuals and may help reduce symptoms related to respiratory infections. OBJECTIVE: The objective of the study was to investigate the effect of the probiotic strain Lactobacillus paracasei subsp. paracasei, L. casei 431 (Chr. Hansen A/S) (hereafter, L. casei 431) on immune response to influenza vaccination and respiratory symptoms in healthy adults. DESIGN: A randomized double-blind, placebo-controlled trial was conducted in 1104 healthy subjects aged 18-60 y at 2 centers in Germany and Denmark. Subjects were randomly assigned to receive an acidified milk drink containing ≥10(9) colony-forming units of L. casei 431 (n = 553) or placebo (n = 551) for 42 d. After 21 d, subjects received the seasonal influenza vaccination. The primary outcome was seroprotection rate (anti-influenza antibody titers by hemagglutination inhibition) 21 d after vaccination. Other outcomes were seroconversion rate and mean titers, influenza A-specific antibodies and incidence, and duration and severity of upper respiratory symptoms. Antibiotic use and use of health care resources were recorded. RESULTS: There was no effect of L. casei 431 on immune responses to influenza vaccination. Generalized linear mixed modeling showed a shorter duration of upper respiratory symptoms in the probiotic group than in the placebo group (mean ± SD: 6.4 ± 6.1 vs. 7.3 ± 9.7 d, P = 0.0059) in the last 3 wk of the intervention period. No statistically significant differences were found for incidence or severity. CONCLUSIONS: Daily consumption of L. casei 431 resulted in no observable effect on the components of the immune response to influenza vaccination but reduced the duration of upper respiratory symptoms. The trial was registered at www.isrctn.com as ISRCTN08280229.


Assuntos
Influenza Humana/imunologia , Lacticaseibacillus casei , Probióticos/administração & dosagem , Infecções Respiratórias/prevenção & controle , Vacinação , Adolescente , Adulto , Animais , Anticorpos Antivirais/sangue , Índice de Massa Corporal , Contagem de Colônia Microbiana , Dinamarca , Método Duplo-Cego , Feminino , Alemanha , Voluntários Saudáveis , Testes de Inibição da Hemaglutinação , Humanos , Vacinas contra Influenza/uso terapêutico , Influenza Humana/prevenção & controle , Masculino , Pessoa de Meia-Idade , Leite , Infecções Respiratórias/imunologia , Resultado do Tratamento , Adulto Jovem
15.
Br J Nutr ; 113(4): 699-707, 2015 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-25622825

RESUMO

Most human intervention studies have examined the effects on a subset of risk factors, some of which may require long-term exposure. The plasma proteome may reflect the underlying changes in protein expression and activation, and this could be used to identify early risk markers. The aim of the present study was to evaluate the impact of regular fish intake on the plasma proteome. We recruited thirty healthy men aged 40 to 70 years, who were randomly allocated to a daily meal of chicken or trout raised on vegetable or marine feeds. Blood samples were collected before and after 8 weeks of intervention, and after the removal of the twelve most abundant proteins, plasma proteins were separated by two-dimensional gel electrophoresis. Protein spots < 66 kDa with a pI > 4·3 visualised by silver staining were matched by two-dimensional imaging software. Within-subject changes in spots were compared between the treatment groups. Differentially affected spots were identified by matrix-assisted laser desorption ionisation-time of flight/time of flight MS and the human Swiss-Prot database. We found 23/681 abundant plasma protein spots, which were up- or down-regulated by the dietary treatment (P < 0·05, q < 0·30), and eighteen of these were identified. In each trout group, ten spots differed from those in subjects given the chicken meal, but only three of these were common, and only one spot differed between the two trout groups. In both groups, the affected plasma proteins were involved in biological processes such as regulation of vitamin A and haem transport, blood fibrinolysis and oxidative defence. Thus, regular fish intake affects the plasma proteome, and the changes may indicate novel mechanisms of effect.


Assuntos
Ração Animal , Aquicultura , Proteínas Sanguíneas/análise , Refeições , Proteoma/análise , Alimentos Marinhos , Truta/crescimento & desenvolvimento , Adulto , Animais , Organismos Aquáticos , Biomarcadores/sangue , Dinamarca , Regulação para Baixo , Humanos , Masculino , Pessoa de Meia-Idade , Análise de Componente Principal , Reprodutibilidade dos Testes , Regulação para Cima , Verduras
16.
J Sci Food Agric ; 94(13): 2600-4, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24436145

RESUMO

Although several meta-analysis studies have been published comparing the quality of food derived from organic and non-organic origin, it is still not clear if food from organic production per se can guarantee product-related added value to consumers. This paper aims to summarize the status quo in order to identify research gaps and suggest future research challenges. Organic food is described according to a quality model already published. The influence of organic production on food quality is structured in primary production and processing. Furthermore, organic food authentication is discussed. Organic food seems to contain fewer pesticide residues and statistically more selected health-related compounds such as polyphenols in plant products and polyunsaturated fatty acids in milk and meat products, but the health relevance for consumers is not clear yet. Comparing food from organic origin with so called 'conventional' food seems not to be appropriate, because 'conventional' is not defined. In organic food quality research a system approach is needed from which systemic markers can be selected. Research on the impact of processing technologies on the quality according to organic principles seems of high relevance, since most of the food is processed.


Assuntos
Criação de Animais Domésticos/métodos , Defesa do Consumidor , Qualidade dos Alimentos , Alimentos Orgânicos , Modelos Biológicos , Agricultura Orgânica/métodos , Ração Animal/análise , Ração Animal/normas , Criação de Animais Domésticos/normas , Criação de Animais Domésticos/tendências , Bem-Estar do Animal/tendências , Animais , Biomarcadores/análise , Defesa do Consumidor/tendências , Análise de Alimentos/métodos , Análise de Alimentos/normas , Manipulação de Alimentos/métodos , Manipulação de Alimentos/normas , Inspeção de Alimentos/métodos , Inspeção de Alimentos/normas , Inspeção de Alimentos/tendências , Alimentos Orgânicos/análise , Alimentos Orgânicos/normas , Humanos , Agricultura Orgânica/normas , Agricultura Orgânica/tendências
17.
Diabetes Care ; 37(1): 88-95, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-23959566

RESUMO

OBJECTIVE High-heat cooking of food induces the formation of advanced glycation end products (AGEs), which are thought to impair glucose metabolism in type 2 diabetic patients. High intake of fructose might additionally affect endogenous formation of AGEs. This parallel intervention study investigated whether the addition of fructose or cooking methods influencing the AGE content of food affect insulin sensitivity in overweight individuals. RESEARCH DESIGN AND METHODS Seventy-four overweight women were randomized to follow either a high- or low-AGE diet for 4 weeks, together with consumption of either fructose or glucose drinks. Glucose and insulin concentrations-after fasting and 2 h after an oral glucose tolerance test-were measured before and after the intervention. Homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity index were calculated. Dietary and urinary AGE concentrations were measured (liquid chromatography tandem mass spectrometry) to estimate AGE intake and excretion. RESULTS When adjusted for changes in anthropometric measures during the intervention, the low-AGE diet decreased urinary AGEs, fasting insulin concentrations, and HOMA-IR, compared with the high-AGE diet. Addition of fructose did not affect any outcomes. CONCLUSIONS Diets with high AGE content may increase the development of insulin resistance. AGEs can be reduced by modulation of cooking methods but is unaffected by moderate fructose intake.


Assuntos
Produtos Finais de Glicação Avançada/administração & dosagem , Resistência à Insulina/fisiologia , Sobrepeso/dietoterapia , Adulto , Glicemia/metabolismo , Método Duplo-Cego , Jejum/sangue , Feminino , Frutose/administração & dosagem , Glucose/administração & dosagem , Teste de Tolerância a Glucose , Humanos , Insulina/metabolismo , Pessoa de Meia-Idade , Sobrepeso/sangue , Adulto Jovem
18.
Eur J Nutr ; 53(2): 661-72, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-23929260

RESUMO

PURPOSE: Advanced glycation end products (AGEs) formed in food during high-heat cooking may induce overeating and inflammation. We investigated whether AGE contents in a single meal affect postprandial appetite and markers of inflammation, endothelial activation, and oxidative stress. METHODS: In total, 19 healthy overweight individuals completed a crossover meal test with two meals of identical ingredients prepared by roasting (H-AGE) or steaming (L-AGE), respectively. Postprandial blood samples were analysed for N(ε)-carboxymethyl-lysine (CML), appetite-regulating gut hormones, glucose, insulin, triacylglycerol, and markers of inflammation and endothelial activation. Subjective appetite ratings and subsequent food intake were also assessed, and urine was analysed for CML, methylglyoxal-derived hydroimidazolone (MG-H1), and F2-isoprostanes. RESULTS: CML content of the H- and L-AGE meals was 5.0 and 2.8 mg, respectively. Plasma CML and urinary CML and MG-H1 tended to be higher after the H-AGE meal. There was no change in subsequent food intake, appetite sensations, or appetite hormone responses between meals, except for the overall ghrelin response, which was higher after the H-AGE meal compared with the L-AGE meal (p = 0.016). There was an increased glycaemic response to the H-AGE meal (p = 0.027) compared with the L-AGE meal. Inflammatory and endothelial activation markers did not differ between meals, but there was an overall effect on endothelial activation (p = 0.021) and on the oxidative marker, F2-isoprostanes, in urine (p = 0.013). CONCLUSION: The present study did not show any pronounced effects of AGEs on appetite and markers of inflammation, but did indicate that AGEs may affect postprandial ghrelin, oxidative stress, and glucose responses.


Assuntos
Apetite/efeitos dos fármacos , Dieta , Endotélio/fisiologia , Produtos Finais de Glicação Avançada/administração & dosagem , Inflamação , Sobrepeso/fisiopatologia , Adulto , Glicemia/análise , Índice de Massa Corporal , Estudos Cross-Over , Endotélio/efeitos dos fármacos , Ingestão de Energia , F2-Isoprostanos/urina , Feminino , Grelina/sangue , Peptídeo 1 Semelhante ao Glucagon/sangue , Temperatura Alta , Humanos , Insulina/sangue , Lisina/análogos & derivados , Lisina/sangue , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo/efeitos dos fármacos , Peptídeo YY/sangue , Período Pós-Prandial , Vapor , Triglicerídeos/sangue
19.
J Sci Food Agric ; 94(13): 2582-94, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24375441

RESUMO

In 2007 EU Regulation (EC) 834/2007 introduced principles and criteria for organic food processing. These regulations have been analysed and discussed in several scientific publications and research project reports. Recently, organic food quality was described by principles, aspects and criteria. These principles from organic agriculture were verified and adapted for organic food processing. Different levels for evaluation were suggested. In another document, underlying paradigms and consumer perception of organic food were reviewed against functional food, resulting in identifying integral product identity as the underlying paradigm and a holistic quality view connected to naturalness as consumers' perception of organic food quality. In a European study, the quality concept was applied to the organic food chain, resulting in a problem, namely that clear principles and related criteria were missing to evaluate processing methods. Therefore the goal of this paper is to describe and discuss the topic of organic food processing to make it operational. A conceptual background for organic food processing is given by verifying the underlying paradigms and principles of organic farming and organic food as well as on organic processing. The proposed definition connects organic processing to related systems such as minimal, sustainable and careful, gentle processing, and describes clear principles and related criteria. Based on food examples, such as milk with different heat treatments, the concept and definitions were verified. Organic processing can be defined by clear paradigms and principles and evaluated according criteria from a multidimensional approach. Further work has to be done on developing indicators and parameters for assessment of organic food quality.


Assuntos
Defesa do Consumidor , Contaminação de Alimentos/prevenção & controle , Manipulação de Alimentos , Qualidade dos Alimentos , Alimentos Orgânicos/análise , Modelos Biológicos , Agricultura Orgânica , Criação de Animais Domésticos/métodos , Criação de Animais Domésticos/normas , Bem-Estar do Animal/tendências , Animais , Biomarcadores/análise , Defesa do Consumidor/tendências , Indústria de Laticínios/métodos , Indústria de Laticínios/normas , União Europeia , Manipulação de Alimentos/normas , Conservação de Alimentos/métodos , Conservação de Alimentos/normas , Alimentos Orgânicos/microbiologia , Alimentos Orgânicos/normas , Humanos , Legislação sobre Alimentos , Agricultura Orgânica/normas
20.
Nutrients ; 5(8): 3287-98, 2013 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-23966109

RESUMO

Dietary fibers (DF) may affect energy balance, an effect often ascribed to the viscous nature of some water soluble DF, which affect luminal viscosity and thus multiple physiological processes. We have tested the hypothesis that viscous linseed DF reduce apparent nutrient digestibility, and limit weight gain, in a randomized feeding trial where 60 male, growing, Wistar rats, with an initial weight of ~200 g, were fed different diets (n = 10 per group): low DF control (C), 5% DF from cellulose (5-CEL), CEL + 5% DF from whole (5-WL) or ground linseed (5-GL), CEL + 5% DF from linseed DF extract (5-LDF), and CEL + 10% DF from linseed DF extract (10-LDF). Diets were provided ad libitum for 21 days. Feed intake and faecal output were measured during days 17-21. Faecal fat excretion increased with increasing DF content and was highest in the 10-LDF group. Apparent fat digestibility was highest with the C diet (94.9% ± 0.8%) and lowest (74.3% ± 0.6%) with the 10-LDF diet, and decreased in a non-linear manner with increasing DF (p < 0.001). Apparent fat digestibility also decreased with increased accessibility of DF (5-WL vs. 5-GL) and when the proportion of viscous DF increased (5-GL vs. 5-LDF). The 10-LDF resulted in a lower final body weight (258 ± 6.2 g) compared to C (282 ± 5.9 g), 5-CEL (281 ± 5.9 g), and 5-WL (285 ± 5.9 g) (p < 0.05). The 10-LDF diet reduced body fat compared to 5-CEL (p < 0.01). In conclusion, DF extracted from linseed reduced apparent energy and fat digestibility and resulted in restriction of body weight gain in growing rats.


Assuntos
Fibras na Dieta/farmacologia , Digestão/fisiologia , Linho/química , Extratos Vegetais/farmacologia , Aumento de Peso/fisiologia , Ração Animal/análise , Animais , Gorduras na Dieta/metabolismo , Metabolismo Energético , Fezes/química , Modelos Lineares , Masculino , Ratos , Ratos Wistar
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