[Effects of cortiphen on human tumor strains transplanted into athymic mice and rats]. / Deistvie kortifena na shtammy opukholei cheloveka, transplantiruemye bestimusnym mysham and krysam.

The antitumour activity of cortiphen synthesized at the All-Union Cancer Research Centre of the USSR Academy of Medical Sciences was studied on human tumour strains transplanted into nude mice and rats. Cortiphen was found to possess an expressed activity to kidney cancer, cancer of corpus uteri, chorionepithelioma, fibrosarcoma. Two strains of colon adenocarcinoma out of three have displayed an expressed sensitivity to cortiphen, while melanoma and Jewing sarcoma strains proved to be weakly sensitive to the preparation.

[Effects of plant polysaccharide paliustran on the growth of human tumor transplants in athymic mice]. / Vliianie rastitel'nogo polisakharida paliustrana na rost transplantatov opukholei cheloveka u bestimusnykh myshei.

Plant polysaccharide palyustran inhibited the growth of human lung carcinoma P-1 transplanted to athymic mice by 60% but failed to do so in human rhabdomyosarcoma. Treatment with palyustran was followed by a 2-fold decrease in lympho- and granulocyte levels, selective inhibition of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase activity in tumor cells and--in single cases--metastatic involvement of the liver.

[The action of hypothalamic hormone on athymic mice with transplantable strains of human tumors]. / Deistvie gormona gipotalamusa na bestimusnykh myshei s perevivaemymi shtammami opukholei cheloveka.

The sensitivity of human melanoma and lung cancer strains transplanted to nude mice to the synthetic hormone of hypothalamus--melanostatin has been defined. Correlation has been noted between the rate of melanoma growth inhibition, decrease in the rate of Na-fluorescent accumulation in the tumor and the tendency towards depression of the activity of energetic metabolism enzymes (SDH and alpha-GPDH) in the treated tumors as compared to control. Moderate lymphopenia and absence of effect on the same enzymes of the lymphocytes was also observed. Fluorescent probes can be used in the estimation of the drug action on the tumor and organs.

[Effect of oxoplatin and platidiam on human melanoma strains and functional activity of blood lymphocytes in athymic mice]. / Deistvie oksoplatiny i platidiama na shtammy melanomy cheloveka i funktsional'nuiu aktivnost' limfotsitov krovi u bectimusnykh myshei.

Oxoplatinum (USSR) caused a more pronounced anticancer effect than platidiam (CSSR) when treating nude mice with the transplantable human melanoma. Moderate lymphopenia was found with therapeutic doses of oxoplatinum and platidiam, but there was no direct inhibition of the energy metabolism of lymphocytes in the peripheral blood. In the cancer cells and in the lymphocytes infiltrating the tumour oxoplatinum caused a significant decrease in the alpha-GPDG activity realizing the binding of the glycolysis and oxidation which might evidence for a definite selective action of oxoplatinum on the human melanoma.

[Effect of chemotherapy on human tumor heterografts and lymphocytes in athymic mice]. / Vliianie khimioterapii na geterotransplantaty opukholei cheloveka i limfotsity u bestimusnykh myshei.

Sensitivity of human serially transplanted tumours (melanoma, hepatoma, lung, stomach and bladder cancer) to monochemotherapy was studied in nude mice. The following groups of nude mice were examined: intact and those with human xenografts (control and mice treated with alkylating agents). Changes in peripheral blood morphology have been revealed and functional activity of the energetic enzymes (SDH and alpha-GPDH) has been cytochemically discovered.

[Antitumor and toxic effects of amotin]. / Izuchenie protivoopukholevogo i toksicheskogo deistviia amotina.

An indole alkaloid isolated from Catharanthus roseus in the Soviet Union and named amotin differs in terpenoid moiety structure of the indole part of the molecule from the foreign preparation vinblastine and its Soviet analog rosevine. In experimental study amotin has exhibited a high antileukemic activity which was more expressed than that of vinblastine. Tolerant doses of amotin cause moderate reversible morphological alterations in hematopoietic organs, gastrointestinal mucosa, liver, kidney, adrenals, testes, ovaries.