RESUMO
Two bismuth(III) compounds of ciprofloxacin (cf) were synthesized. The crystal structure of one--(cfH2) (cfH) [BiCl6].2H2O (cfH2 = doubly protonated molecule of cf, cfH = protonated molecule of cf)--is presented and discussed. The compound crystallizes in the monoclinic space group P 21/c with a = 17.758(4), b = 7.600(10), c = 31.908(6) A, beta = 101.03(2)0, Z = 4. The charge of the isolated hexachlorobismuthate(III) anions is compensated with protonated of molecules (ionic interactions). One of the cf molecules is protonated at carbonyl oxygen O(1) and nitrogen N(24) of the piperazine residue, and the other at N(24) only. Two water molecules participate in the hydrogen bond network. Antimicrobial activity of this compound was tested against different microorganisms. The results of TG and FT-IR measurements are also included.
Assuntos
Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Bismuto/química , Bismuto/farmacologia , Ciprofloxacina/análogos & derivados , Fluoroquinolonas , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Compostos Organometálicos/química , Compostos Organometálicos/farmacologia , Ciprofloxacina/química , Ciprofloxacina/farmacologia , Cristalografia por Raios X , Resistência Microbiana a Medicamentos , Estrutura Molecular , Espectroscopia de Infravermelho com Transformada de FourierRESUMO
Two novel metal-quinolone compounds have been synthesized and characterized by analytical, spectroscopic, and X-ray diffraction methods. The crystal structure of both, (erxH2) [FeCl4]Cl and (kinoH2)[CuCl4]. H2O, is presented and discussed (erxH2 = doubly protonated form of enrofloxacin, kinoH2 = doubly protonated form of the second quinolone). In both compounds, the hydrogen atom is bonded between the 4-keto oxygen O(1) and carboxylic oxygen O(11), thus preventing the bonding of the metal to this part of the molecule. Antimicrobial activities of metal-quinolone compounds were tested against different microorganisms.
