1.
Bioorg Med Chem Lett
; 26(12): 2866-2869, 2016 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27161805
RESUMO
Reported herein are a series of reverse indoles that represent novel non-steroidal mineralocorticoid receptor (MR) antagonists. The key structure-activity relationships (SAR) are presented below. This reverse indole series is exemplified by a compound that demonstrated efficacy in an acute natriuresis rodent model comparable to marketed MR antagonists, spironolactone and eplerenone.