1.
Bioorg Med Chem Lett
; 16(9): 2333-6, 2006 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15946842
RESUMO
A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha2-delta protein. Further characterization of alpha2-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1.