RESUMO
Blood serum selenium levels were measured in healthy subjects of six districts located throughout the province of Mérida, Venezuela. There were either high (87-115 micrograms/L) or low (58-72 micrograms/L) serum selenium-containing districts. Serum selenium in males from three districts were statistically significantly lower (p less than 0.001) than in females. There was a general tendency for serum selenium to increase with age. On the average, a reduction in cancer was observed in the districts with high serum selenium content. Further, serum selenium was lower in male patients from the Mérida district with cancer disease. Association between selenium in soil and in the blood serum of healthy subjects has been observed.
Assuntos
Neoplasias/epidemiologia , Selênio/sangue , Poluentes do Solo/análise , Adolescente , Adulto , Feminino , Humanos , Neoplasias Hepáticas/epidemiologia , Neoplasias Pulmonares/epidemiologia , Masculino , Pessoa de Meia-Idade , Selênio/análise , Fatores Sexuais , Neoplasias Gástricas/epidemiologia , Venezuela/epidemiologia , Abastecimento de ÁguaRESUMO
Lead content in head hair of 53 gas station workers together with an equal number of normal controls was determined. Samples of hair were washed with ethanol and water and microwave-aided wet digested prior to the determination of lead by flow injection/atomic absorption spectrometry. The lead content in hair of the gas station workers (48.7 +/- 17.5 micrograms/g) was significantly higher than that of the normal controls (17.2 +/- 8.1 micrograms/g). The effects of washing and sample digestion procedures, head sampling site, hair color, age, smoking habits and duration of exposure to the metal are discussed.
Assuntos
Gasolina/efeitos adversos , Cabelo/química , Chumbo/análise , Exposição Ocupacional , Adolescente , Adulto , Fatores Etários , Análise de Injeção de Fluxo , Cor de Cabelo , Humanos , Masculino , Micro-Ondas , Valores de Referência , Reprodutibilidade dos Testes , Fumar , Solubilidade/efeitos da radiação , Manejo de Espécimes/métodos , Espectrofotometria AtômicaRESUMO
The effect of eight doses of 10,000, 20,000 and 30,000 UI of vitamin D2 administered every other day to three groups of rats, on the activities of some enzymes in the animals' liver was evaluated. In general terms, findings revealed a decrease in the activities of glucose-6-phosphatase, phosphorylase and arginase. Likewise, an increase of the activities of maltase and of glutamic oxaloacetic and glutamic pyruvic transaminases was observed. Furthermore, the activities of cholinesterase and alpha-amylase also varied depending on the vitamin D2 doses administered.
Assuntos
Arginase/metabolismo , Ergocalciferóis/farmacologia , Glucose-6-Fosfatase/metabolismo , Fígado/enzimologia , Fosforilases/metabolismo , Transaminases/metabolismo , Animais , Masculino , Ratos , Ratos EndogâmicosRESUMO
El proposito del presente trabajo fue averiguar si habia un efecto toxico aditivo entre aflatoxina B1 y monocrotalina (el principio activo de la Crotalaria spectabilis), y determinar si los niveles de los toxicos administrados producirian residuos detectables en tejidos. Sesenta pavos, machos, saludables de un dia de nacidos fueron asignados al azar a cuatro grupos de tratamiento. Los bajos valores en proteinas totales, albumina, alfa-globulina, Beta-globulina, peso corporal, peso del higado en el grupo que recibio la combinacion de las dos substancias, fueron asociados a un efecto toxico aditivo de la Crotalaria y aflatoxina. Residuos de aflatoxina B1 y M1 fueron encontrados en los rinones de los animales que recibieron aflatoxina; y deshidroretronecina fue detectada en higados de los pavos que recibieron semillas de Crotalaria
Assuntos
Masculino , Animais , Aflatoxinas , Carcinógenos , Alcaloides de PirrolizidinaRESUMO
En este estudio se realizo la evaluacion del efecto de ocho dosis de 10.000 y 20.000 U.I. de vitamina D2, administradas cada dos dias, sobre la actividad serica de algunas enzimas hepaticas en ratas. Los resultados se compararon con los obtenidos en ratas normales y testigos. De los resultados obtenidos en esta investigacion se pudo comprobar que la administracion de la vitamina D2 tiene efectos potencialmente toxicos para el higado. Tambien se sugiere que un enzimograma tipo, para una intoxicacion por vitamina D2 pudiera estar caracterizado por una disminucion de la actividad de la alfa-amilasa, fosfatasa alcalina, 5' nucleotidasa, deshidrogenasa lactica, leucinaminopeptidasa, colinesterasa y gamma-glutamiltranspeptidasa; un aumento significativo en la actividad de la transaminasa, glucosa-6-fosfatasa, maltasa acida, fosfohexosaisomerasa y ceruloplasmina, y, un aumento o disminucion (respectivamente, con dosis de 10.000 o mayores de 20.000 U.I. de vitamina D2) en la actividad de la arginasa