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J Clin Pathol ; 60(1): 98-100, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17213356

RESUMO

We report a case of a 9-cm mixed epithelial and stromal tumour of the kidney in an obese 70-year-old woman with diabetes. The ovarian-type stroma had a spindle cell component that was positive for progesterone receptors and had the hitherto unreported presence of abundant foci of luteinised stromal cells with characteristic immunohistochemical positivity to alpha-inhibin, calretinin, aromatase and gonadotropin-releasing hormone (GnRH) receptors. We conclude that the stromal component is identical to ovarian cortical stroma. We believe that ovarian-type stroma occurs in extragenital tumours as a result of an epithelial-stromal interaction in an environment of hormonal hyperstimulation.


Assuntos
Neoplasias Renais/patologia , Tumor Misto Maligno/patologia , Neoplasias Epiteliais e Glandulares/patologia , Idoso , Diabetes Mellitus Tipo 2/complicações , Feminino , Humanos , Neoplasias Renais/etiologia , Tumor Misto Maligno/etiologia , Neoplasias Epiteliais e Glandulares/etiologia , Obesidade/complicações , Células Estromais/patologia
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