Quality Assurance and Technology-Enabled Curation of Oncology Real-World Data: The Importance of Individual Quality Reviews.

Quality assurance is the foundation of clinical data abstraction. Meaningful insights can only be drawn from quality data. Through the development of robust quality-control processes for technology-enabled curation, Syapse's certified tumor registrars enrich real-world oncology data, supporting oncology patient care and research for a network of community health systems.

Defect-Directed Growth of Symmetrically Branched Metal Nanocrystals.

Branched plasmonic nanocrystals (NCs) have attracted much attention due to electric field enhancements at their tips. Seeded growth provides routes to NCs with defined branching patterns and, in turn, near-field distributions with defined symmetries. Here, a systematic analysis was undertaken in which seeds containing different distributions of planar defects were used to grow branched NCs in order to understand how their distributions direct the branching. Characterization of the products by multimode electron tomography and analysis of the NC morphologies at different overgrowth stages indicate that the branching patterns are directed by the seed defects, with the emergence of branches from the seed faces consistent with minimizing volumetric strain energy at the expense of surface energy. These results contrast with growth of branched NCs from single-crystalline seeds and provide a new platform for the synthesis of symmetrically branched plasmonic NCs.

Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase.

20-fluoro-17(20)-pregnenolone derivatives were designed as enol mimics of pregnenolone. All of the targeted, novel fluoroolefins were potent inhibitors of C17(20) lyase.