[Clinical and morphological risk factors for epilepsy in patients with glial and metastatic brain tumors]. / Kliniko-morfologicheskie faktory riska razvitiya epilepsii u bol'nykh s glial'nymi i metastaticheskimi opukholyami golovnogo mozga.

OBJECTIVES: To estimate the incidence of epileptic seizures in patients with glial and metastatic brain tumors and to identify clinical and morphological risk factors for epileptic seizures in patients with glial and metastatic brain tumors. MATERIAL AND METHODS: The study included 225 (88.6%) patients with glial brain tumors and 29 patients (11.4%) with metastatic tumors. RESULTS: Statistically significant differences in the incidence of epileptic seizures depending on age, histological characteristics of the tumor, degree of malignancy, tumor localization, involvement of the cerebral cortex, the presence of the midline shift were obtained. CONCLUSIONS: Epilepsy and epileptic seizures was found to develop in 51.11% and 24.14% of cases in glial and metastatic brain tumors, respectively. Risk factors for developing epileptic seizures include younger age (up to 57 years), histological characteristics corresponding to diffuse astrocytomas, anaplastic astrocytomas, oligodendrogliomas, oligoastrocytomas, grade I-III malignancy, lesion of the temporal lobe, involvement of the cerebral cortex. Factors that reduce the risk for attacks include age over 57, histological characteristics corresponding to glioblastomas and metastatic tumors, grade IV malignancy, subcortical localization of the tumor, damage to the occipital lobe, involvement of the commissural pathways, subtentorial localization of the tumor, the absence of lesions of the temporal and frontal lobes of the brain, the involvement of both brain hemispheres, damage to two or more brain lobes, the presence of a midline shift.

[For the history of creation of central anatomicopathological facility of the Ministry of Defence].

The system of anatomicopathological facilities was created in 30s of XX century and first years of the Great Patriotic War. The goal of this system was to increase the effectiveness of Sanitary Corps of the Red Army. These anatomicopathological facilities analyzed causes of death of injured soldiers during all stages of the system of treatment-evacuative support of troops and mistakes made by medical specialists during first aid treatment. Organisational forms of anatomicopathological activity were changed and developed according to acquired battle experience. The main stage of formation of anatomicopathological service of the Red Army, and in fact the finished period in organisational formation of anatomicopathological service, was establishment of Central anatomicopathological facility - main methodological, organisational, coordinating and monioring center of anatomicopathological activity of the Armed Forces of the Russian Federation.