A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety.

Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with obesity to effectively manage their disease. Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension. We designed the Vibrating Ingestible BioElectronic Stimulator (VIBES) pill, an ingestible device that performs luminal vibratory stimulation to activate mechanoreceptors and stroke mucosal receptors, which induces serotonin release and yields a hormonal metabolic response commensurate with a fed state. We evaluated VIBES across 108 meals in swine which consistently led to diminished food intake (~40%, P < 0.0001) and minimized the weight gain rate (P < 0.05) as compared to untreated controls. Application of mechanoreceptor biology could transform our capacity to help patients suffering from nutritional disorders.

Quantifying canine interactions with smart toys assesses suitability for service dog work.

There are approximately a half million active service dogs in the United States, providing life-changing assistance and independence to people with a wide range of disabilities. The tremendous value of service dogs creates significant demand, which service dog providers struggle to meet. Breeding, raising, and training service dogs is an expensive, time-consuming endeavor which is exacerbated by expending resources on dogs who ultimately will prove to be unsuitable for service dog work because of temperament issues. Quantifying behavior and temperament through sensor-instrumented dog toys can provide a way to predict which dogs will be suitable for service dog work, allowing resources to be focused on the dogs likely to succeed. In a 2-year study, we tested dogs in advanced training at Canine Companions for Independence with instrumented toys, and we discovered that a measure of average bite duration is significantly correlated with a dog's placement success as a service dog [Adjusted OR = 0.12, Pr(>|z|) = 0.00666]. Applying instrumented toy interactions to current behavioral assessments could yield more accurate measures for predicting successful placement of service dogs while reducing the workload of the trainers.