[Cross-reacting HLA antigens as a factor increasing the risk of childlessness in a family]. / Perekrestnoreagiruiushchie antigeny sistemy HLA kak fator, povyshaiushchii risk bezdetnosti v sem'e.

A comparative analysis of HLA phenotypes of fertile and infertile spouses revealed that among the infertile the sum of spouses showed compatibility in two or three HLA antigens. A detailed analysis also showed that 10 infertile couples exhibited identical and 2 antigens with a similar structure and function with so-called cross-reactions increasing the histocompatibility index to 75%. The significance of these facts for infertility risk factors is discussed.