RESUMO
BACKGROUND: The arcuate eminence (AE) is an anatomically consistent bony protrusion located on the upper surface of the petrous bone that has been previously studied as a reference for lateral skull base approaches. There is a paucity of information in the neurosurgical literature seeking to improve the safety of the extended middle cranial fossa (MCF) approach using detailed morphometric analysis of the AE. OBJECTIVE: To evaluate the use of the AE as an anatomical landmark to help with early identification of the internal acoustic canal (IAC) in MCF approaches by means of a cadaveric study, using a new morphometric reference termed the "M-point." METHODS: A total of 40 dry temporal bones and 2 formalin-preserved, latex-injected cadaveric heads were used. The M-point was established as a new anatomic reference by identifying the intersection of a line perpendicular to the alignment of the petrous ridge (PR), originating from the midpoint of the AE, with the PR itself. Subsequent anatomical measurements were performed to measure the distance between M-point and IAC. Additional distances, including PR length and the anteroposterior and lateral AE surfaces, were also measured. RESULTS: The mean distance between the M-point and the center of the IAC was 14.9 mm (SD ± 2.09), offering a safe drilling area during an MCF approach. CONCLUSIONS: This study provides novel information on identification of a new anatomic reference point known as the M-point that that can be used to improve early surgical identification of the IAC.
Assuntos
Osso Petroso , Osso Temporal , Humanos , Osso Temporal/cirurgia , Osso Temporal/anatomia & histologia , Osso Petroso/cirurgia , Osso Petroso/anatomia & histologia , Base do Crânio , Fossa Craniana Média/cirurgia , Fossa Craniana Média/anatomia & histologia , CadáverRESUMO
El término transgénero hace referencia a aquellas personas cuya identidad de género (masculino -femenino) difiere del sexo (hombre mujer). La persona transgénero presenta un conflicto entre la identidad sexual y su condición biológica, debido a que esta última, ya está ajustada a unas características que están dadas desde el nacimiento. Una de las mayores dificultades que presentan es en la feminización de voz, debido a que esta es percibida como la del género opuesto. Por ello, usualmente realizan cambios vocales sin una técnica adecuada, recurriendo principalmente a tratamientos quirúrgicos u hormonales, desconociendo la terapia fonoaudiológica como una alternativa para mejorar su calidad vocal e interacción social. Dado lo anterior, el objetivo de este trabajo fue determinar la efectividad de la intervención fonoaudiológica para la feminización de la voz en una persona Transgénero MTF (Male to Female). Se utilizó un diseño descriptivo, cuantitativo, usando un diseño longitudinal de serie de estudio de caso de reversión ABA. La intervención se estructuró, principalmente, en tres apartados: evaluación inicial, intervención y reevaluación final. Los resultados mostraron una variación significativa en las cualidades acústico-perceptuales de la voz, la que presentó mayores características de una voz femenina, con modificaciones en el patrón fonorespiratorio y en la postura. En conclusión, la intervención fonoaudiológica fue efectiva debido a que se lograron cambios que permitieron lograr una voz más femenina en la persona tratada.
The term transgender denotes a person whose gender identity (male-female) is different from their sex (men-women). A transgender person presents a contradiction between sexual identity and biological condition, because the latter is determined by certain given characteristics since birth. One of the most difficult issues is the feminization of the person's voice (in the case if male to female), since it is perceived as being in the opposite end of gender. For this reason, usually male to female transgenders engage in vocal changes without appropriate techniques, resorting mostly to surgical procedures or hormonal treatments and ignoring speech and language therapy as an alternative to improve their vocal quality and social interaction. Therefore, the main goal of this work was to determine the effectiveness of the phoniatric intervention in order to produce the feminization of the voice in a transgender individual MTF. The methodology used is a quantitative, descriptive, using a longitudinal design of ABA reversion case study series. The intervention was structured in three main sections: initial evaluation, intervention and final re-evaluation. The results showed a significant variation in the acoustic perceptual qualities of the voice, with a more feminine voice involving modifications in the phonorespiratory pattern and in the posture. In conclusion, the phoniatric intervention was effective because achieved changes led to a more feminine voice.
Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Transexualidade/terapia , Treinamento da Voz , Fonoaudiologia/métodos , Feminização , Pessoas Transgênero/psicologia , Autoimagem , Qualidade da VozRESUMO
Introducción: La desnutrición es un desafío pendiente que influye nocivamente en el desarrollo de los niños/as y de una nación. Objetivo: Evaluar la evolución del estado nutricional de niños/as <5 años ingresados a un programa alimentario durante el año 2012. Materiales y Métodos: Estudio longitudinal (cohorte), descriptivo, analítico de beneficiarios del Programa Alimentario Nutricional Integral (PANI) en el 2012.Variables sociodemográficas fueron consideradas, el diagnóstico nutricional según criterios OMS según puntaje zPeso/Edad (zP/E), Índice de Masa Corporal/Edad (zIMC/E), Talla/Edad (zT/E). Resultados: Fueron procesados datos de 4946 niños/as <5años. Edad media 17,5m (0,03-59 m), 50,3% varones; 51,4% del área rural. Al ingreso, tuvieron media zP/E-1,71±0,7DE, zIMC/Edad -1,31±1,12DE y zT/E -1,34±1,30 DE. El zP/E en controles sucesivos aumentó a -0,36 DE en el 12vo. control, el zIMC/E a 0,26DE,zT/E a -0,91 de manera significativa (ANOVA p<0,0001). 22,6% presentaban Desnutrición Global-DG y 77,4% de riesgo de desnutrir al ingreso, estas prevalencias fueron de 3,4% y 21% respectivamente con 75,6% de niños/as sin desnutrición al último control ((2,p<0,0001). 21,9% tuvieron desnutrición por IMC, y 38,5%% de riesgo de desnutrir, estas prevalencias fueron de 3,1% y 10,7% al 12vo. control. Del 26% de Desnutrición Crónica-DC, se pasó a 16% al final de la intervención. Conclusiones: La desnutrición infantil disminuye significativamente con el apoyo de un programa alimentario.
Introduction: Malnutrition is a pending challenge which has a harmful influence on children's development of and for a nation. Objective: To evaluate the evolution of nutritional status of children <5 years admitted to an Integrated Nutritional Food Program (PANI) during the year 2012. Materials and Methods: Longitudinal (cohort), descriptive and analytical study of beneficiaries of the Integrated Nutritional Food Program (PANI) in 2012. Sociodemographic variables were considered, nutritional diagnosis was according to WHO criteria with zscore Weigth/Age (z(W/A), Body Mass Indesx/Age (zBMI/A) and Heigth/Age (zH/A). Results: Data were processed from 4946 children <5 years old. Mean age 17.5m (0.03-59 m), 50.3% males; 51.4% of the rural area. At entry, they had mean zW/A -1.71 ± 0.7DE, zBMI/A -1.31 ± 1.12 DE and zH/A -1.34 ± 1.30DE. The zW/A in successive controls increased to -0.36DE in the 12th control, zBMI/A at 0.26DE, zH/A at -0.91 significantly (ANOVA p <0.0001). 22.6% presented Global Malnutrition-DG and 77.4% risk of malnutrition at admission, these prevalences were 3.4% and 21%, respectively, with 75.6% of children without malnutrition at the last control ((2, p<0.0001). 21.9% had malnutrition due to BMI, and 38.5% had a risk of malnutrition, these prevalences were 3.1% and 10.7% at the 12th control. Of the 26% of Chronic Malnutrition-DC, it was changed to 16% at the end of the intervention. Conclusions: Child undernutrition decreases significantly with the support of a food program.
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Evidence has implicated apoptosis as a mechanism underlying cell demise in diverse neurodegenerative diseases including Parkinson's disease (PD). Endogenous toxins and other stress signals activate the sphingomyelin pathway increasing the levels of ceramide, an important regulator of cell death. In the present paper we have analysed the contribution of PI3K/AKT-GSK3ß and MAPK (ERK and JNK) pathways to cell death in a catecholaminergic cell line following exposure to C(2)-ceramide. We also explored the potential neuroprotective action of insulin-like growth factor-1 (IGF-1) and neurotrophin-3 (NT3). We demonstrated that C(2)-ceramide-induced cell death is associated to an early decrease in phosphorylation (inhibition) of PI3K/AKT and ERK, followed by phosphorylation (activation) of JNK and de-phosphorylation (activation) of glycogen synthase kinase-3 beta (GSK3ß). NT3 and IGF-1 increased survival at early time points, but only IGF-1 is capable to attenuate C(2)-ceramide-mediated neuronal death, and this neuroprotection is associated to strong and permanent activation of AKT and inhibition of GSK3ß. In conclusion, C(2)-ceramide initiates a series of events including an early inactivation of PI3K/AKT and ERK pathways followed by activation of JNK and activation of GSK3ß and neuronal death, changes that are counteracted by IGF-1.