Understanding the multifunctionality of pyroligneous acid from waste biomass and the potential applications in agriculture.

Efforts have been directed to the development of environmentally friendly processes and manufacturing of green products, use of renewable energy and more sustainable agricultural practices. Pyroligneous acid (PA) is a byproduct of biomass pyrolysis that consists of a complex mixture of bioactive substances. The complexity and richness of PA composition have opened a window for PA application in agriculture and mitigation of environmental pollution. This review brings a brief historical on the use of PA and regulatory policies adopted in Brazil, China, Japan and Thailand for PA application in agriculture. The composition and stability of PAs of several origins are presented, together with a discussion of the use of PA to boost plant growth and crop productivity, remove toxic metals from soil, inhibit soil ureases, mitigate the emission of greenhouse gases, control phytopathogen proliferation and weed dissemination. A great variety of biomass types are reported as feedstock to produce PA with distinct chemically diverse and active substances at wide-ranging concentrations. PA has been shown to successfully improve farming practices in a more sustainable fashion. The disclosure of the mechanisms of action that drive the PA's effects, together with the pursue of safety and efficacy data in a case-by-case way to address toxicity and shelf stability, will be valuable to expand the use of PA worldwide for food production.

Acute infection with Strongyloides venezuelensis increases intestine production IL-10, reduces Th1/Th2/Th17 induction in colon and attenuates Dextran Sulfate Sodium-induced colitis in BALB/c mice.

Helminth infection can reduce the severity of inflammatory bowel disease. However, the modulatory mechanisms elicited by helminth infection are not yet fully understood and vary depending on the experimental model. Herein we evaluated the effect of acute infection of BALB/c mice with Strongyloides venezuelensis on the clinical course of ulcerative colitis induced by Dextran Sulfate Sodium (DSS) treatment of these animals. For the experiments, S. venezuelensis-infected BALB/c mice were treated orally with 4% DSS solution for seven days. As controls, we used untreated S. venezuelensis infected, DSS-treated uninfected, and untreated/uninfected BALB/c mice. During DSS treatment, mice from the different groups were compared with regards to the clinical signs related to the severity of colitis and intestinal inflammation. Mice acutely infected with S. venezulensis and treated with DSS had reduced clinical score, shortening of the colon, and tissue inflammation. Moreover, DSS-treated and infected mice showed reduced IL-4, INF-γ, and IL-17 levels and increase of IL-10 production in the colon and/or in the supernatant of mesenteric lymph nodes cell cultures that resulted in lower eosinophil peroxidase and myeloperoxidase activity in colon homogenates, when compared with DSS-treated uninfected mice. DSS-treated infected mice also preserved the intestine architecture and had normal differentiation of goblet cells and mucus production in the colon mucosa. In conclusion, the data indicate that the clinical improvement reported in DSS-treated infected mice was accompanied by the lower production of Th1/Th2/Th17 pro-inflammatory cytokines, stimulation of IL-10, and induction of mucosal repair mechanisms.