RESUMO
Biomedical applications need tailor-made scaffolds that exhibit biomimetic mechanical properties. In this context, electrospinning has emerged as a technique with promising features for their production. However, the electrospun scaffolds mechanical behavior as a function of the microstructure and nanofiber properties is still poorly understood. Besides, multiscale constitutive modeling appears as a powerful design tool, not only able to characterize electrospun structures, but also to determine the fiber properties and scaffold microstructure that would achieve the objective response. With focus in this last aspect, we developed a multiscale constitutive model for nanofibrous structures that takes into account the material constitutive properties, scaffold microstructure, and nanofiber progressive recruitment. A statistical approach of the nanofibers tortuosity with a modified Gaussian distribution was adopted, which allowed for reproducing the scaffolds macroscopic nonlinear mechanical behavior. It was observed that such behavior arises even if the nanofibers response is considered as mechanically linear. Experimental data from pressure vs. diameter inflation tests of electrospun tubular scaffolds was used to validate the model. In addition, the influence of the microstructural parameters upon the macroscopic constitutive behavior was studied. Finally, the model parameters were adjusted to obtain a vascular graft able to reproduce the mechanical response of a target natural tissue. The current study presents a step towards understanding, characterizing, and optimizing the mechanical properties of nanofibrous biomaterials.
