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This paper introduced the management of focus drugs in Ningbo, and evaluated the preliminary results by comparing the changes in terms of the income of these drugs before and after the measures taken. More measures should be taken by establishing a unified drug catalogue, strengthening the assessment, carrying prescription comment and periodic notification. The pharmacists can play a leading role in clinical rational drug use. These efforts can serve for scientific control of the unreasonable growth of medical expenses.
RESUMO
OBJECTIVE:To establish a method for the content determination of zolpidem tartrate in microsamples of rat plas-ma. METHODS:Rats were given zolpidem tartrate solution 3 mg/kg intragastrically,and 0.2 ml blood sample were collected and isolated. 50 μl plasma was precipitated by methanol,and the supernatant was determined by HPLC-fluorescence combined with ex-ternal method. Agilent HC-C18 column was used with mobile phase consisted of 0.03 mol/L KH2PO4 solution(containing 0.2% tri-ethylamine)-methanol (33∶67,V/V) at flow rate of 1.0 ml/min. The excitation and emission wavelengths were 254 nm and 390 nm,respectively. The sample size was 20 μl. RESULTS:The linear ranges of zolpidem tartrate in plasma was 2-200 μg/L(r=0.999 7),and the limit of quantification was 2 μg/L. The method recoveries of zolpidem were (96.96 ± 1.35)%-(105.0 ± 5.36)%(RSD=2.20%-4.88%,n=5),and extraction recoveries were (79.72 ± 0.01)%-(80.77 ± 0.02)%(RSD=1.34%-3.90%,n=5). The intra-day and inter-day RSDs were 1.40%-5.10% and 3.22%-9.25%(n=5),respectively. CONCLUSIONS:The method is simple,sensitive and suitable for the content determination of zolpidem tartrate in microsamples of plasma.
RESUMO
Traditional Chinese herbal medicines have been used for treating various ailments since medicine be- gan.The belief that natural products are much safer than synthetic drugs has led to dramatic growth of herbal medi- cine usage.Like synthetic drugs,herbal preparations also have potential to cause adverse effects and drug interac- tions.In this paper,pharmacokinetic studies on herb- drug interactions are reviewed and discussed in order to promote usage of herbs rationally and safely.
