RESUMO
The authors used surveys and interviews to study participants' motivations for enrolling and perceptions of the weaknesses and strengths of two distance learning programs administered by the University of North Carolina at Chapel Hill School of Public Health (SPH): the MPH in Public Health Leadership and a certificate program organized collaboratively with the Mahidol University SPH in Thailand. Chief motivations were career advancement, job performance improvement, convenience, and obtaining a degree from a reputable institution. Strengths included the curriculum, networking opportunities, and administrative and technical support. Concerns included quality of interaction with faculty and instructional methods.
Assuntos
Escolha da Profissão , Comportamento do Consumidor/estatística & dados numéricos , Educação a Distância/métodos , Motivação , Administração em Saúde Pública/educação , Estudantes de Ciências da Saúde/psicologia , Adulto , Currículo , Educação a Distância/normas , Humanos , Entrevistas como Assunto , Liderança , Pessoa de Meia-Idade , North Carolina , Avaliação de Programas e Projetos de Saúde/estatística & dados numéricos , Faculdades de Saúde Pública/organização & administração , Estudantes de Ciências da Saúde/estatística & dados numéricos , Inquéritos e Questionários , TailândiaRESUMO
Within the hippocampus, stimulus-transcriptional coupling plays an important role in post-seizure neuronal adaptation, post-ischemic cell death and the induction of long-term potentiation. To identify additional mediators of hippocampal transcriptional responses a targeted approach was developed and used to characterize the spectrum of nuclear hormone receptors expressed within this brain region. cDNAs encoding the DNA-binding domains of six different members of the nuclear hormone receptor superfamily were isolated. A majority were identical or closely related to receptors known to be expressed within the hippocampus. Two additional isolates, HZF-2 and HZF-3, encode the DNA-binding domain of novel members of the nuclear hormone receptor superfamily.
Assuntos
Núcleo Celular/metabolismo , Proteínas de Ligação a DNA/biossíntese , Hipocampo/metabolismo , Família Multigênica , Proteínas do Tecido Nervoso/biossíntese , Receptores de Superfície Celular/biossíntese , Fatores de Transcrição/biossíntese , Sequência de Aminoácidos , Animais , Sequência de Bases , DNA Complementar/genética , Proteínas de Ligação a DNA/genética , Regulação da Expressão Gênica , Ligantes , Masculino , Dados de Sequência Molecular , Proteínas do Tecido Nervoso/genética , Poli A/genética , Poli A/isolamento & purificação , Reação em Cadeia da Polimerase , RNA Mensageiro/genética , RNA Mensageiro/isolamento & purificação , Ratos , Ratos Sprague-Dawley , Receptores de Superfície Celular/genética , Receptores de Glucocorticoides/química , Receptores de Glucocorticoides/classificação , Receptores de Fator de Crescimento Neural/química , Receptores de Fator de Crescimento Neural/classificação , Receptores dos Hormônios Tireóideos/química , Receptores dos Hormônios Tireóideos/classificação , Alinhamento de Sequência , Homologia de Sequência , Fatores de Transcrição/genética , Transcrição Gênica , Dedos de Zinco/genéticaRESUMO
The effect of chronic consumption of diets containing either different sources of dietary fibre (8% guar, 8% pectin, or 8% multifibre) or low carbohydrate upon carbohydrate tolerance was examined in rats. Weight gain was significantly lower throughout the entire 28-day study period with the guar group and after 20 days with the multifibre group. When tested with a liquid meal (1 g sucrose/kg body weight) after 14 days on the diets, only the guar rats had significantly lower fasting and postprandial plasma glucose concentrations. After 28 days, the improved carbohydrate tolerance persisted in the guar rats and started to appear in the multifibre rats. Pectin and low carbohydrate diets had no effect upon either weight gain or carbohydrate tolerance. Consuming the fibre diets did not affect jejunal sucrase activities. Jejunal glucose uptake activity was significantly diminished when measured in fasting guar rats while postprandially activities were similar to controls. Jejunal Na-K-ATPase activities in fasting and postprandial guar rats were not related to changes in glucose uptake. These studies confirm that only certain types of dietary fibre improve carbohydrate tolerance and suggest that reduced weight gain and altered intestinal glucose uptake are factors involved in the chronic fibre effect.
