Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease.

Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing the development of dry eye disease (DED). The currently available eye drops for DED treatment are palliative, short-lived and frequently administered due to the short precorneal residence time. Here, we developed nanozyme-based eye drops for DED by exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) and poly(vinyl alcohol) (PVA) to overcome these problems. The resultant formulation (PBnZ), which has dual-ROS scavenging abilities and prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect to alleviate DED. In vitro and in vivo experiments revealed that PBnZ could eliminate excess ROS through both its multienzyme-like activity and the ROS-scavenging activity of borate bonds. The positively charged nanozyme-based eye drops displayed a longer precorneal residence time due to physical adhesion and the dynamic borate bonds between phenyboronic acid and PVA or o-diol with mucin. The in vivo results showed that eye drops could effectively alleviate DED. These dual-function PBnZ nanozyme-based eye drops can provide insights into the development of novel treatment strategies for DED and other ROS-mediated inflammatory diseases and a rationale for the application of nanomaterials in clinical settings.

Luminescent/Temperature-Sensing Properties of Multifunctional Rare-Earth Upconversion Kevlar Nanofiber Composite under 1550 nm.

The unique properties of upconversion nanoparticles (UCNPs) are responsible for their diverse applications in photonic materials, medicine, analytics, and energy conversion. In this study, water-soluble rare-earth upconversion nanomaterials emitting green, yellow, and red light under 1550 nm excitation were synthesized. These nanomaterials were then integrated into water-soluble Kevlar nanofibers (KNFs) to fabricate ultra-thin composite films exhibiting favorable mechanical characteristics. The characterization of the products, along with their luminescent, mechanical, and temperature-sensing properties, was examined. The results indicate that the composite material exhibited varying colors based on the doped nanoparticles when subjected to 1550 nm excitation. The composite showed highly sensitive temperature-sensing properties, excellent luminescent characteristics, and superior mechanical strength. This study suggests that KNFs are effective carriers of UCNPs. This study offers a reference for the utilization of rare-earth upconversion in anti-counterfeiting displays, wearable health monitoring, and remote temperature sensing.

N-rich chitosan-derived porous carbon materials for efficient CO2 adsorption and gas separation.

Capturing and separating carbon dioxide, particularly using porous carbon adsorption separation technology, has received considerable research attention due to its advantages such as low cost and ease of regeneration. In this study, we successfully developed a one-step carbonization activation method using freeze-thaw pre-mix treatment to prepare high-nitrogen-content microporous nitrogen-doped carbon materials. These materials hold promise for capturing and separating CO2 from complex gas mixtures, such as biogas. The nitrogen content of the prepared carbon adsorbents reaches as high as 13.08 wt%, and they exhibit excellent CO2 adsorption performance under standard conditions (1 bar, 273 K/298 K), achieving 6.97 mmol/g and 3.77 mmol/g, respectively. Furthermore, according to Ideal Adsorption Solution Theory (IAST) analysis, these materials demonstrate material selectivity for CO2/CH4 (10 v:90 v) and CO2/CH4 (50 v:50 v) of 33.3 and 21.8, respectively, at 1 bar and 298 K. This study provides a promising CO2 adsorption and separation adsorbent that can be used in the efficient purification process for carbon dioxide, potentially reducing greenhouse gas emissions in industrial and energy production, thus offering robust support for addressing climate change and achieving more environmentally friendly energy production and carbon capture goals.

Hollow CuS nanoparticles equipped with hydroxyapatite/hyaluronic acid coating for NIR/pH dual-responsive drug delivery.

The near-infrared (NIR)/pH dual-responsive nanoplatform shows great potential in remote photothermal therapy for tumor on account of the near-infrared window in biological tissue and the mild acidic environment in tumor cells. CuS nanoplatform has become a rising star in the field of photothermal agents due to its excellent NIR responsiveness and photostability. In this work, hollow CuS nanoparticles with high photothermal conversion efficiency (42.42 %) were synthesized through a novel surfactant micelle-assisted method. Then, CuS@hydroxyapatite (HAP)/hyaluronic acid (HA) nanoclusters with controllable drug release property were prepared by capping HAP and HA on the surface of CuS via electrostatic self-assembly approach. The hollow structure of CuS and the large specific surface area of HAP ensure an outstanding doxorubicin hydrochloride (DOX) loading efficiency of 99.2 % in CuS@HAP/HA nanoclusters. The introduction of HA effectively retards the initial burst release of DOX and ensures the excellent biocompatibility of nanoclusters. More importantly, CuS@HAP/HA displays distinct NIR/pH dual-responsive drug release properties owing to the excellent NIR responsiveness of hollow CuS and the gradual dissolution of HAP under acidic conditions. This work provides an environmentally benign method to prepare CuS-based nanoclusters with excellent NIR/pH responsive drug delivery properties, which has great potential in remote photothermal therapy.

Ultrafast self-assembly of supramolecular hydrogels toward novel flame-retardant separator for safe lithium ion battery.

Traditional polyolefin separators for lithium-ion batteries (LIBs) often experience limited thermal stability and intrinsic flammability, resulting in great safety risks during their usage. Therefore, it is highly important to develop novel flame-retardant separators for safe LIBs with high performance. In this work, we report a flame-retardant separator derived from boron nitride (BN) aerogel with a high BET surface area of 1127.3 m2 g-1. The aerogel was pyrolyzed from a melamine-boric acid (MBA) supramolecular hydrogel, which was self-assembled at an ultrafast speed. The in-situ evolution details of the nucleation-growth process of the supramolecules could be observed in real-time using a polarizing microscope under ambient conditions. The BN aerogel was further composited with bacterial cellulose (BC) to form a BN/BC composite aerogel with excellent flame-retardant performance, electrolyte-wetting ability and high mechanical property. By using the BN/BC composite aerogel as the separator, the developed LIBs exhibited high specific discharge capacity of 146.5 mAh g-1 and excellent cyclic performance, maintaining 500 cycles with a capacity degradation of only 0.012% per cycle. The high-performance flame-retardant BN/BC composite aerogel represents a promising candidate for separators not only in LIBs but also in other flexible electronics.

A novel bilayer heterogeneous poly(ionic liquid) electrolyte for high-performance flexible supercapacitors with ultraslow self-discharge.

Flexible supercapacitors with high power density and long cyclic stability represent a promising candidate to be used as power supplies for portable electronics, but often suffer from the disadvantages of a limited working voltage and rapid self-discharge (spontaneous drop of open-circuit voltage). Here, we design a bilayer heterogeneous poly(ionic liquid) electrolyte (BHPE) consisting of a polycation complex and a polyanion complex with different zeta potentials to suppress the self-discharge of flexible symmetric supercapacitors. The resultant BHPE-based supercapacitors using active carbon/carbon nanotube composite electrodes exhibit a high working potential of 3.0 V and an energy density of 33 W h kg-1, which are comparable with those of devices obtained by using a homogeneous poly(ionic liquid) electrolyte (HPE). More significantly, the developed BHPE-based supercapacitor charged under forward bias exhibits a self-discharge time of 23.2 h, which is at least twice that of the device charged under reverse bias and is also much superior to those of HPE-based supercapacitors. The BHPE-based supercapacitors also possess excellent mechanical flexibility and stability, due to the stabilized interface contact between two layers of poly(ionic liquid)s.

A chitosan-based self-healing hydrogel for accelerating infected wound healing.

Wound infection causes irregular tissue closure, often with prolonged healing. Traditional therapies based on antibiotic delivery have resulted in reduced therapeutic efficiency and drug resistance. Such features make it highly desirable to develop an antibiotic-free material for wound infection in clinical applications. Herein, a self-healing antibacterial hydrogel was designed to realize the treatment of S. aureus-infected wounds. The design of the dynamic imine bond endows hydrogels with self-healing and adaptive properties, which could cover the irregular wound and improve the safety of administration. In addition, benefiting from quaternized chitosan, the designed hydrogels also present fascinating antimicrobial properties and favorable biocompatibility. The evaluation in a rat skin wound infection model indicates that the fascinating antimicrobial effect accelerates wound healing by the designed hydrogels. This facile design of an antibiotic-free material allows effective wound infection management, which may be promising in coping with other complex wound healings.

Graphdiyne and Its Derivatives as Efficient Charge Reservoirs and Transporters in Semiconductor Devices.

2D graphdiyne (GDY), which is composed of sp and sp2 hybridized carbon atoms, is a promising semiconductor material with a unique porous lamellar structure. It has high carrier mobility, tunable bandgap, high density of states, and strong electrostatic interaction ability with ions and organic functional units. In recent years, interests in applying GDYs (GDY and its derivatives) in semiconductor devices have been growing rapidly, and great achievements have been made. Attractively, GDYs could act as efficient reservoirs and transporters for both carriers and ions, which endows them with enormous potential in future novel optoelectronics. In this review, the progress in this field is systematically summarized, aiming to bring an in-depth insight into the GDYs' intrinsic uniqueness. Particularly, the effects of GDYs on carrier dynamics and ionic interactions in various semiconductor devices are succinctly described, analyzed, and concluded.

Supramolecular Framework Constructed by Dendritic Nanopolymer for Stable Flexible Perovskite Resistive Random-Access Memory.

The 3D supramolecular framework (3D-SF) is constructed in this work through the hydrogen bond assisted self-assembly of spherical dendritic nanopolymer to regulate the flexibility, stability, and resistive switching (RS) performance of perovskite resistive random-access memory (RRAM). Herein, the 3D-SF network acts as the perovskite crystallization template to regulate the perovskite crystallization process due to its coordination interaction of functional groups with the perovskite grains, presenting the uniform, pinhole-free, and compact perovskite morphology for stable flexible RRAM. The 3D-SF network in situ stays at the perovskite intergranular boundaries to crosslink the perovskite grains. The RS performance of 3D-SF-modified perovskite RRAM device is evidently improved to the ON/OFF ratio of 105 , the cycle number of 500 times, and the data retention time of 104 s. The 50-days exposure of unencapsulated RRAM device at ambient environment still makes the ON/OFF ratio to be kept at ≈104 , indicating the potential of long-term stable multilevel storage in the high-density data storage. The bending action under different radius also does not change the RS performance due to the excellent bending-resistant ability of 3D-SF-modified perovskite film. This work explores a novel polymer additive strategy to construct the 3D supramolecular framework for stable flexible perovskite optoelectronic devices.

Natural wood-derived free-standing films as efficient and stable separators for high-performance lithium ion batteries.

A sustainable and low-cost separator is highly required for electrochemical energy storage systems. Herein, a type of modified natural wood film with excellent mechanical properties, ion conductivity and thermal stability is fabricated for high-performance lithium ion batteries. Using the modified natural wood film as a separator, the fabricated symmetric cell exhibits a more stable and lower plating/stripping voltage for Li than that of the cell with a commercialized polypropylene (PP) separator. The LiFePO4/Li half-cell with the modified wood film separator shows a small polarization voltage and high discharge capacity because of the multi-level nanostructure and abundant functional groups of the modified wood films. The results suggest that the modified wood films are a promising candidate for use as separators in lithium ion batteries. As desired, the LiFePO4/Li half-cells with the modified wood film separator deliver much higher discharge capacities and more stable Coulomb efficiency over two hundred charge/discharge cycles than the cell based on the PP separator. The present work systematically investigate the feasibility of abundant and cheap natural wood-derived materials for use as efficient separators instead of synthetic polymers for high-performance lithium ion batteries with long cycle life.

A Polyanionic Strategy to Modify the Perovskite Grain Boundary for a Larger Switching Ratio in Flexible Woven Resistive Random-Access Memories.

The intergranular interface modification of organic-inorganic hybrid perovskites (OHP) is an important issue to regulate the flexibility, stability, and resistive switching (RS) performance of resistive random-access memories (RRAMs). A novel strategy of polymer additives for OHP intergranular interface modification is explored in this work with the polyanionic backbone to improve the distribution of cage-shaped cavity molecules at the perovskite grain boundaries. Specifically speaking, poly(1-adamantylammonium acrylate) (PADAm) is first synthesized through the acid-base reaction of polyacrylic acid with 1-adamantylamine to simultaneously realize the introduction of a cage-shaped cavity molecule and the polyanionic backbone. Herein, organic ammonium cations 1-adamantylammonium (ADNH3+) in PADAm are applied as the cage-shaped cavity molecules to tune the dielectric property by being anchored at the perovskite grain boundaries. Meanwhile, polyacrylic anions in PADAm play the role of the polyanionic backbone to produce the more uniform distribution of ADNH3+. Simultaneously, the flexibility and stability of OHP RRAM devices are also improved due to the introduction of the polyanionic backbone. Consequently, the 4% ADNH3I-modified planar device exhibits the stable nonvolatile RS behavior with an on/off ratio of ∼104, even with one-month exposure under an ambient environment. Importantly, the introduction of PADAm in the flexible fibrous crosspoint of functional fiber Al@MAPbI3:PADAm and bare Al fiber further increases the on/off ratio to 108 due to the effectively improved distribution of hollow cage-shaped ADNH3+ at the perovskite intergranular interfaces together with the application of the fibrous crosspoint device configuration. Especially, these excellent crosspoint RRAM devices can be integrated into the woven fibrous RRAM array in the thermal plastic packaging configuration. In addition, the excellent multilevel RS behavior can also be realized in the woven fibrous RRAM array, indicating potential high-density data storage. This work provides a novel strategy of polymer additives bearing the polyanionic backbone to improve the flexibility, stability, and RS performance of perovskite RRAM devices.

NIR/pH-responsive chitosan hydrogels containing Ti3C2/AuNRs with NIR-triggered photothermal effect.

Remotely multi-responsive chitosan (CS) hydrogels holds great promise in the design of anticancer drug carriers. In this paper, near-infrared (NIR)-/pH-dual responsive CS/ß-GP/Ti3C2@AuNRs hybrid hydrogel was prepared based on CS/ß-glycerol phosphate disodium salt (ß-GP) crosslinking system embedded with NIR-responsive Ti3C2@gold nanorods (AuNRs) nanosheets. Excess ß-GP promoted the formation of massive electronegative cavities, which endowed hybrid hydrogels with high drug loading efficiency for electropositive DOX (around 88.5 %). The collapse of chitosan network in acidic medium gave the hybrid hydrogel with distinct pH response. In addition, the distinct temperature increase owing to the strong NIR responsiveness of Ti3C2@AuNRs nanosheets would accelerate the DOX release dramatically. Therefore, NIR-, pH- and thermal-multi-responsiveness would synergistically endow CS/ß-GP/Ti3C2@AuNRs hybrid hydrogel with notable NIR-triggered photothermal effect and remotely controllable drug delivery properties.

Flexible stretchable electrothermally/photothermally dual-driven heaters from nano-embedded hierarchical CuxS-Coated PET fabrics for all-weather wearable thermal management.

The multifunctional photoelectronic devices are recently attracting much more attention due to their potential enlarged applications. The flexible stretchable electrothermally/photothermally dual-driven heaters for all-weather wearable thermal management are presented in this work with nano-embedded hierarchical CuxS-coated PET fabrics. Herein, the hierarchical nano-embedded CuxS film is fabricated via a simple chemical bath method for high electrical conductivity and highly efficient inelastic collision of electro/photo-generated carriers. The hierarchical nano-embedded CuxS morphology produces the low sheet resistance of 1.26 Ω sq-1 and the super low total heat transfer coefficient of 3.256 × 10-5 W/oC·mm2, which lead to the high-efficient electro/photo-dual-driven heating effect in the CuxS@PET fabrics. The saturated temperature on the as-fabricated flexible wearable heaters reaches up to 172 °C. The thermal conversion devices also bear the excellent stability, reproducibility, stretchability, controllability and corrosion-resistant characteristics. Interestingly, their excellent thermal conversion performance could be achieved by freely exchanging the driving power sources, such as electricity-supplying equipment, 635-nm laser, infrared physiotherapy lamp and solar simulator, which provides a necessary precondition for the all-weather applications of flexible wearable heaters. The as-fabricated electro/photo-dual-driven heaters on the CuxS@PET fabrics have the promising applications in wearable electronics, all-weather self-heating facilities, out/in-vivo physiotherapy, and so on.

Swelling-reconstructed chitosan-viscose nonwoven fabric for high-performance quasi-solid-state supercapacitors.

Fabrics are often used as freestanding substrates for energy storage devices owing to their hierarchical porous structure and excellent mechanical flexibility. However, it is still a challenge to achieve a high loading mass of electroactive materials for outstanding electrochemical performance. In this work, with the help of high swelling property of chitosan, the chitosan-viscose nonwoven fabric (CVF) is successfully reconstructed to expand its specific surface area for flexible conductive substrates in the supercapacitors. Then, multi-walled carbon nanotubes (MWCNTs) are coated on the surface of crosslinked chitosan-viscose nonwoven fabric (c-CVF) to form the conductive framework. Subsequently, polypyrrole (PPy) is deposited by in-situ interfacial polymerization on the above conductive MWCNT/c-CVF substrate. The optimized PPy/MWCNT/c-CVF composite electrode shows not only a high electrical conductivity of 285.9 ± 1.2 S·cm-1, but also a prominent specific capacitance of 10112.9 mF·cm-2 at 2 mA·cm-2. Moreover, the prepared composite electrode also exhibits a high flexibility and good rate capability, in which the 70.3% capacitance is retained when the current density increases from 2 mA·cm-2 to 10 mA·cm-2. Besides, the quasi-solid-state symmetric supercapacitor, being assembled with the optimized composite fabric electrodes, produces the maximum areal specific capacitance of 1748.0 mF·cm-2 at 2 mA·cm-2 and the outstanding energy density of 155.4 µWh·cm-2 at a power density of 0.88 mW·cm-2. This work provides an effective approach to reconstruct the blended nonwoven fabric structure for high-performance flexible conductive substrate in the supercapacitors.

A lingering mouthwash with sustained antibiotic release and biofilm eradication for periodontitis.

Dental plaque biofilms are believed to be one of the principal virulence factors in periodontitis resulting in tooth loss. Traditional mouthwashes are limited due to the continuous flow of saliva and poor drug penetration ability in the biofilm. Herein, we fabricated an antibiotic delivery platform based on natural polysaccharides (chitosan and cyclodextrin) as a novel mouthwash for the topical cavity delivery of minocycline. The penetration and residence mechanisms demonstrate that the platform can prolong the residence time up to 12 h on biofilms. Furthermore, sustained release can enhance the penetration of drugs into biofilms. In vitro antibiofilm experimental results indicated that the mouthwash effectively kills bacteria and eradicate biofilms. Effective treatment in vivo was confirmed by the significantly reduced dental plaque and alleviated inflammation observed in a rat periodontitis model. In summary, this novel platform can improve antibiofilm efficiency and prevent drugs from being washed away by saliva, which may provide benefits for many oral infectious diseases.

Constructing a hierarchically structured KNi0.67Co0.33PO4·H2O-graphene hydrogel/Ni foam electrode for superior all-solid-state supercapacitor.

A monolithic supercapacitor electrode of a KNi0.67Co0.33PO4·H2O-graphene composite hydrogel supported on Ni foam (KNCP-GH/NF) is first prepared by a one-step hydrothermal method, which achieves notable improvements in the electrode surface area and mass-loading of active materials. The KNCP-GH/NF electrode enjoys a hierarchical open-porous structure, where the KNCP-GH composite hydrogel fills in the voids in NF and the porous graphene hydrogel (GH) simultaneously provides a large support surface for growing active KNCP nanoflowers. Accordingly, the KNCP-GH/NF electrode exhibits a strikingly high capacity of 3240 mC cm-2 (876 C g-1) at 2 mA cm-2 and a satisfactory rate performance with 78.3% retention at 100 mA cm-2. Further, an all-solid-state asymmetric supercapacitor, constituted by using KNCP-GH/NF and Fe2P/GH/NF as the cathode and anode, respectively, and PVA-KOH as the solid-state gel electrolyte, delivers a high energy density of 69.2 W h kg-1 (3.9 mW h cm-3) and a power density of 13 229 W kg-1 (720 mW h cm-3) as well as notable cyclability with 81.2% capacity retention after 10 000 charge/discharge cycles. These attractive performances suggest a promising potential for a hierarchically structured KNCP-GH/NF electrode for the high-performance energy storage application.

Chitosan/hyaluronic acid based hollow microcapsules equipped with MXene/gold nanorods for synergistically enhanced near infrared responsive drug delivery.

Ti3C2 MXenes, a novel two-dimensional material, have attracted lots of attention in biomedical filed for its large surface area and excellent near-infrared (NIR) responsiveness. In this paper, a pH/near-infrared (NIR) multi-responsive drug delivery platform consisted of hollow hydroxyapatite (HAP), chitosan (CS)/hyaluronic acid (HA) multilayers, gold nanorods (AuNRs) and MXene had been fabricated via a layer-by-layer (LbL) approach. Chitosan/hyaluronic acid multilayers were deposited on the surface of hollow HAP to retard the burst release of DOX in the initial delivery stage. MXenes and AuNRs equipped on the surface of hybrid matrix greatly enhanced the photothermal conversion efficiency of the microcapsules. Due to the collapse of electrostatic force among chitosan/hyaluronic acid multilayers and the dissolution of HAP under acidic condition, as well as the synergistically enhanced photothermal effect between MXene and AuNRs, HAP/CS/HA/MXene/AuNRs microcapsules exhibited outstanding pH-/NIR-responsive drug delivery properties. The present paper provides an attractive method to prepare chitosan/hyaluronic acid based pH/NIR multi-responsive hybrid microcapsules with excellent photothermal conversion efficiency and biocompatibility, which has great potential in the field of remotely controlled drug delivery.

Integration of interstitial fluid extraction and glucose detection in one device for wearable non-invasive blood glucose sensors.

Wearable non-invasive glucose sensors that can provide human a painless and portable means to monitor their blood glucose and manage their health condition draw great attentions, recently. Non-invasive human glucose sensors by detecting glucose in interstitial fluid (ISF) extracted through a reverse iontophoresis (RI) approach have been widely investigated, but the current challenges are their complex structure and instability for continuous monitor. Herein, we demonstrate a simple two-electrode non-invasive blood glucose sensor, which is fabricated by using graphene/carbon nanotubes/glucose oxidase composite textile and graphene/carbon nanotube/silver/silver chloride composite textile as the working electrode and counter electrode, respectively. By using one single device, extraction of ISF through RI process is firstly conducted by loading a certain electric current between two electrodes, then the glucose concentration in the ISF is detected through an amperometric approach by using the same two electrodes. The feasibility of these non-invasive glucose sensors is validated on porcine skin, nude mice and human. The blood glucose concentration calculated according to the response currents of the two-electrode sensors is highly consistent with that measured by commercial glucose meter. Furthermore, the used textile-like electrodes provide the non-invasive blood glucose sensors with excellent flexible and wearable properties, which make them promising to be integrated with other electronic units for monitor and management of human health.

Regulating the electrochemical behaviours of a hierarchically structured Co3(PO4)2/Ni-Co-O for a high-performance all-solid-state supercapacitor.

Battery-type materials (e.g., transition metal phosphates) have been intensely explored in supercapacitors due to their rich electroactive sites and high theoretical capacity. Yet poor rate performance, resulting in a low energy density at high current density, limits their further applications. Herein, an improvement in rate performance resulting from enhanced surface capacitive behaviour contribution has been observed in a hierarchically structured Co3(PO4)2/Ni-Co-O@Ni foam (CPNO-12). The optimized CPNO-12 synthesized through a facile hydrothermal treatment also exhibits a striking gravimetric and areal capacity of 1410C g-1 (14 100 mC cm-2) at 5 mA cm-2 and superb cyclability (91% of retention at 50 mA cm-2 after 12 000 cycles), which can be attributed to its unique hierarchical porous structure and high mass loading per area. More importantly, a high-performance all-solid-state asymmetric supercapacitor with CPNO-12 and Fe2P/graphene hydrogel@Ni foam as positive and negative electrodes respectively has been assembled; the device delivering a maximum energy density of 95 W h kg-1 (32 mW h cm-3) and maximum power density of 4000 W kg-1 (800 mW cm-3) has the potential to power sophisticated systems. These attractive performances confirm that an enhancement of capacitive behaviour in battery-type materials holds the promise for fabricating high-performance supercapacitors.

Phase-transfer-assisted synthesis of cysteine-Ag nanoparticles/graphene oxide nanocomposite and its enhanced performance in antibiosis and biosensing.

We report a facile, rapid, phase-transfer-assisted process to prepare Ag nanoparticles (AgNP) loaded graphene oxide (GO) nanocomposite, by using cysteine as a highly-effective phase transfer agent for AgNP movement from organic phase to water and subsequently as a covalent linkage for immobilizing AgNP on GO. The obtained c-Ag/GO nanocomposite possesses high nanoparticle loading efficiency, small particle size and monodispersity, strong binding force and good water dispersibility, which endow it with great potential in a variety of bio-applications. To illustrate potentail application, c-Ag/GO and its derivatives c-Ag/rGO were used for antibiosis and biosensing, respectively. The c-Ag/GO composite demonstrates high antibacterial activity against E. coli with a minimal bactericidal concentration of 10 µg ml-1. The biosensor based on c-Ag/rGO exhibits rapid and sensitive response for uric acid detection with a detection limit of 0.025 µM, a sensitivity of 5.76 µA mM-1 and a wide linear range of 0.025 ∼ 2250 µM. The comparative analysis with relevant nanocomposites also reveals the precedence of c-Ag/GO in these applications, thus highlighting the advantages of the developed preparation method for c-Ag/GO.