[Reliability of caregivers in assessing the quality of life of stroke survivors: an explorative study]. / Affidabilità del caregiver nel valutare la qualità di vita del paziente con ictus cerebrale: uno studio esplorativo.

UNLABELLED: Reliability of caregivers in assessing the quality of life of stroke survivors: an explorative study. Introduction. Not all stroke survivors are able to assess their quality of life (QOL), thus a caregiver could provide important information on patients' QOL. OBJECTIVE: To assess caregiver's reliability in measuring QOL in stroke survivors. METHOD: Fifty (50) patient-caregiver dyads were recruited. Patients, hospitalized in rehabilitation facilities, were administered the Stroke Impact Scale 3.0 (SIS 3.0) patient version, the Barthel Index, the Modified Rankin Scale, and the National Institute of Health Stroke Scale. Caregivers completed the SIS 3.0 proxy version. RESULTS: The mean scores of the SIS 3.0 patient version were very similar to the proxy version and ranged from 19.1 vs 16.2 for the Hand function domain to 83.81 vs 81.85 for the Communication domain. Caregivers tended to underestimate patients' QOL although scores were not significantly different. Intraclass correlations between the patient version and the proxy version of the SIS 3.0 were highly significant (p<0.001), with coefficient over 0.80. Lower coefficients were observed for the Social participation (0.58), Emotion (0.64) and Communication (0.79) domains. CONCLUSIONS: Caregivers were more reliable in assessing the physical rather than psychosocial domains.

Neurophysiological and functional MRI evidence of reorganization of cortical motor areas in cerebral arteriovenous malformation.

Functional magnetic resonance imaging (fMRI) research has shown that brain arteriovenous malformations (AVMs) lead to reorganization of cortical motor areas. Since it is known that blood oxygenation level-dependent signal in fMRI may be influenced by the hemodynamic perturbation associated with the presence of the AVM, in the present study, a combined exploration with fMRI and transcranial magnetic stimulation was performed in a patient with a right rolandic AVM in order to explore the relationship between neuronal and hemodynamic activity. The combined protocol of investigation adopted in this study was able to provide significant information regarding neuronal activity of the different cortical areas that partake to post-lesional reorganization.

Effect of Vigabatrin on motor responses to transcranial magnetic stimulation: an effective tool to investigate in vivo GABAergic cortical inhibition in humans.

In this study, transcranial magnetic stimulation (TMS) of the hand primary motor area was used to test possible excitability changes induced by the administration of Vigabatrin (Gamma-Vinyl-gamma-aminobutryic acid;4-amino-hex-5-enoic acid; GVG), a selective GABAergic drug, on cortical inhibitory mechanisms in healthy subjects. In a group of 15 healthy volunteers, the level of motor cortical excitability was studied by means of paired-pulse TMS (p-TMS) protocols exploring the early (1-6 ms of interstimulus intervals, ISI) and the late cortical inhibition (20-250 ms ISI), and by evaluating the cortical silent period (CSP) duration obtained in response to single pulse stimulation of cortical motor area. In all participants TMS procedures were carried out before and after administering GVG for three consecutive days at a daily dosage of 50 mg/kg. Three months later, a third TMS recording session was repeated to investigate possible long-lasting GVG effects on cortical excitability. GVG induces relevant changes of cortical excitability consisting in an increase of late cortical inhibition in response to the long ISI p-TMS and in a prolonged duration of the CSP. No significant change in the early cortical inhibition was observed in response to the short ISI p-TMS. The analysis of peripheral motor excitability was also assessed, with no effects. The present electrophysiological data show that GVG is able to induce a significant increase of the late cortical inhibition, whereas it does not affect the early cortical inhibition. These data suggest that the great availability of synaptic GABA differently acts on the inhibitory circuitries controlled by different GABA-receptor subtypes.