RESUMO
The aim of this prospective study was to analyze the incidence of serious infections and changes in immunological markers after liver transplantation (LT) in a cohort of patients with hepatitis C virus (HCV). This study included 34 patients who had LT, 20 patients with HCV etiology (HCV group), and 14 patients with alcoholic etiology (non-HCV group). Patients with HCV were more likely to have severe infections (80%) in comparison with patients in the non-HCV group (42%) (P=0.05). The HCV group had a 3-fold greater likelihood of early severe bacterial infections than the non-HCV group. At 1 week post LT, the HCV group showed higher values of CD19+ B cells/microL than the non-HCV group (P<0.05). At weeks 4 and 12 post LT, the HCV group had lower values of CD19+ B cells/microL (P<0.05). Our data suggest that HCV recurrence after LT was associated with a high incidence of early severe infections and immunological alterations, which may be related to this increased risk.
Assuntos
Bacteriemia/epidemiologia , Fungemia/epidemiologia , Hepatite C/complicações , Transplante de Fígado/efeitos adversos , Pneumonia Bacteriana/epidemiologia , Adulto , Idoso , Antígenos CD19/metabolismo , Linfócitos B/imunologia , Bacteriemia/imunologia , Bacteriemia/microbiologia , Feminino , Fungemia/imunologia , Fungemia/microbiologia , Hepacivirus/imunologia , Hepatite C/imunologia , Hepatite C/virologia , Humanos , Incidência , Cirrose Hepática/complicações , Cirrose Hepática/imunologia , Cirrose Hepática/virologia , Cirrose Hepática Alcoólica/complicações , Cirrose Hepática Alcoólica/imunologia , Cirrose Hepática Alcoólica/virologia , Transplante de Fígado/imunologia , Masculino , Pessoa de Meia-Idade , Pneumonia Bacteriana/imunologia , Pneumonia Bacteriana/microbiologiaRESUMO
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