Assuntos
Carcinoma de Células Escamosas , Pele , Sulfonamidas , Humanos , Glândulas Écrinas , Carbamatos , MetaplasiaAssuntos
Assistência Perinatal , Guias de Prática Clínica como Assunto , Feminino , Humanos , GravidezRESUMO
High affinity 3H-imipramine binding and 3H-serotonin uptake to platelets was evaluated in nine untreated adolescent enuretics (ages 13-18) and nine age- and sex-matched controls. A significant decrease in the maximal binding of 3H-imipramine (Bmax) was observed in the enuretics as compared to the controls. No alteration in the affinity of 3H-imipramine to its binding sites (Kd) or in serotonin uptake kinetic parameters (Vmax, Km) was detected. The lack of correlation between Bmax and Vmax values might indicate that the binding sites for imipramine and the sites for serotonin uptake are not identical.
Assuntos
Plaquetas/metabolismo , Enurese/metabolismo , Imipramina/sangue , Serotonina/sangue , Adolescente , Feminino , Humanos , MasculinoRESUMO
The authors evaluated high-affinity [3H]imipramine binding and [3H]serotonin uptake to platelets in eight adolescent and 10 adult patients who met DSM-III criteria for obsessive-compulsive disorder in comparison with those of normal control subjects of similar ages. The maximal binding of [3H]imipramine was significantly lower in adults and adolescents with obsessive-compulsive disorder than in the control subjects. No differences between groups in the affinity of [3H]imipramine to its binding sites or in serotonin uptake kinetic measures were detected. The lower density of [3H]imipramine binding sites in platelet membrane in patients with obsessive-compulsive disorder might implicate involvement of the serotonergic system or might represent an adaptive response to a chronic disease.
Assuntos
Proteínas de Transporte , Imipramina/metabolismo , Transtorno Obsessivo-Compulsivo/metabolismo , Receptores de Droga , Serotonina/metabolismo , Adolescente , Adulto , Fatores Etários , Plaquetas/metabolismo , Doença Crônica , Feminino , Humanos , Cinética , Masculino , Pessoa de Meia-Idade , Transtorno Obsessivo-Compulsivo/sangue , Transtorno Obsessivo-Compulsivo/fisiopatologia , Receptores de Neurotransmissores/metabolismo , Receptores de Serotonina/metabolismo , Serotonina/fisiologiaRESUMO
High affinity [3H]imipramine binding and [3H]serotonin uptake to platelets were investigated in 17 anorexic females aged 15-18 years as compared to 15 healthy females of similar ages. A significant decrease in the density of [3H]imipramine binding sites was observed in anorexics as compared to controls (368 +/- 40 vs 517 +/- 38 fmoles/mg protein, p less than 0.01). No alteration in Kd values or in the kinetic parameters of serotonin uptake (Vmax, Km) were noted. The fact that the decrease in imipramine binding is not accompanied by a parallel reduction in serotonin uptake might indicate that anorexia nervosa is not ultimately related to major depression and that the imipramine binding site is not identical to the serotonin uptake site.
