Assuntos
Anemia de Fanconi/complicações , Leucoplasia Oral/diagnóstico , Recidiva Local de Neoplasia/diagnóstico , Segunda Neoplasia Primária/diagnóstico , Alelos , Criança , Diagnóstico Diferencial , Anemia de Fanconi/cirurgia , Transplante de Células-Tronco Hematopoéticas , Heterozigoto , Humanos , Leucoplasia Oral/genética , Perda de Heterozigosidade/genética , Masculino , Repetições de Microssatélites/genética , Segunda Neoplasia Primária/genéticaRESUMO
A sialoadenite aguda consiste em uma inflamação aguda das glândulas salivares de origem infecciosa. Geralmente se caracteriza por edema, aumento de temperatura, enrijecimento, dor e diminuição ou ausência de salivação da glândula afetada. Porém, é difícil avaliar corretamente essas mudanças, somente através de exame clínico, portanto, os exames complementares podem auxiliar de forma fundamental no diagnóstico e tratamento. Neste trabalho, é descrito um caso de sialoadenite supurativa aguda em glândula submandibular no qual uma paciente de 70 anos, leucoderma, gênero feminino, apresentava queixa de discreta sintomatologia dolorosa, tendo o diagnóstico sido confirmado através do exame de ultrassonografia e o tratamento de escolha medicamentoso.
Acute sialoadenitis is an acute inflammation of the salivary glands resulting from an infection. It is generally characterized by edema, an increase in temperature, stiffness, pain, and reduced or absent salivation of the gland affected. However, it is difficult to correctly evaluate these alterations relying solely on a clinical examination, since complementary investigations may be of fundamental importance in the diagnosis and treatment of this disorder. This paper reports a case of a white 70-year-old female patient, leukoderma, presenting with mild pain, who was diagnosed as having acute suppurative sialoadenitis in the submandibular gland. The diagnosis was confirmed by ultrasound and drugs were the treatment of choice.
Assuntos
Cálculos das Glândulas Salivares/terapia , Glândulas Salivares , SialadeniteRESUMO
BACKGROUND: The purpose of this study was to compare the immunolocalization of vascular endothelial growth factor (VEGF) in salivary glands of bone marrow transplant (BMT) recipients with normal controls and between the different stages of chronic graft-versus-host disease (cGVHD). In addition, the impact of the immunolocalization of VEGF on the survival rate of BMT patients was investigated as well. METHODS: Labial salivary glands obtained at the day 100+ from 36 consecutive patients, who underwent BMT, were included in the study. The streptavidin-biotin-peroxidase complex stain was used to detect VEGF in the salivary glands. Time of death after BMT was displayed by means of the Kaplan-Meier method for the following parameters: age and gender of the patients, donor gender, acute GVHD, cGVHD staging at the labial salivary glands, primary disease, platelet and neutrophils counts on day of biopsy, stem cell, oral mucositis, parenteral nutrition, oral lichenoid lesions of GVHD, conditioning regimen and immunolocalization degree of VEGF in labial salivary glands. The data were initially analyzed by means of the log-rank test and then included in the Cox's proportional hazard model. RESULTS: No differences on the immunolocalization of VEGF in the labial salivary glands of BMT recipients and control group or between the different stages of glandular cGVHD were noted. Both univariate and multivariate analysis of the survival rate showed significance of 5% only for platelet count over 100 x 109/l on the day of biopsy and male donor gender. CONCLUSIONS: Platelet count over 100 x 109/l and male donor gender are positive predictive factors on the survival rate after BMT. In addition, the immunolocalization of VEGF in salivary glands is not altered in BMT recipients at day 100+ and is not influenced by the stage of cGVHD.
