Effect of restrictive cumulative fluid balance on 28-day survival in invasively ventilated patients with moderate to severe ARDS due to COVID-19.

This study aimed to evaluate the effect of two restrictive cumulative fluid balance (CFB) trends on survival and on major clinical outcomes in invasively ventilated patients with moderate to severe respiratory distress syndrome (ARDS) due to SARS-CoV-2. Prospective data collection was conducted on patients in the intensive care unit (ICU) originating from a tertiary university hospital. The primary outcomes were the risk association between the CFB trend during D0 to D7 and 28-day survival. The secondary outcomes were ICU mortality, in-hospital mortality, the need for invasive ventilation at D28, administration of vasoactive drugs at D7, time on invasive ventilation after D7, and length of ICU and hospital stay. 171 patients were enrolled in the study and divided according to their CFB trends during seven days of follow-up using model-based clustering [median CFB negative trend (n = 89) - 279 ml (- 664 to 203) and (n = 82) median CFB positive trend 1362 ml (619-2026)]. The group with CFB negative trend showed a higher chance of surviving 28-day in the ICU (HR: 0.62, 95% CI 0.41-0.94, p = 0.038). Moreover, this group had a reduced length of stay in the ICU, 11 (8-19) days versus 16.5 (9-29) days p = 0.004 and presented lower rates (OR = 0.22; 95% CI 0.09-0.52) of invasive ventilation after 28-days in the ICU. In patients invasively ventilated with moderate to severe ARDS due to COVID-19, the collective who showed a negative trend in the CFB after seven days of invasive ventilation had a higher chance of surviving 28 days in the ICU and lower length of stay in the ICU.

Increasing the detection distance of remote NMR using wireless inductive coupling coil.

Unilateral nuclear magnetic resonance (UNMR) spectrometers have been applied in a variety of fields such as petrochemistry, materials science, and process control 1 . In UNMR measurements the sample is placed outside of the UNMR sensor and the signal intensity is reduced almost exponentially as the sample-to-sensor distances increases. To expand the detection limits of remote UNMR sensors, wireless inductive coupling was proposed and tested. This strategy was proved to reduce signal attenuation due to sample detachment from sensor, resulting in an increase in detection distance by one order of magnitude (i.e., from few millimeters to few centimeters). This novel approach broadens the potential applications of UNMR sensors and opens new opportunities in several areas, from chemical to biomedical applications.