Proposed recommendations for the management of HIV post-exposure prophylaxis after sexual, injecting drug or other exposures in Europe.

Post-exposure prophylaxis (PEP) is the standard of care for a healthcare worker (HCW) accidentally exposed to an HIV infected source person (occupational exposure), but this is not the case for non-occupational exposures. Very few national guidelines exist for the management of non-occupational exposures to HIV in Europe, contrarily to the occupational ones. The administration of non-occupational post-exposure prophylaxis (NONOPEP) for HIV may be justified by: a biological plausibility, the effectiveness of PEP in animal studies and occupational exposures in humans, efficacy in the prevention of mother to child HIV transmission, and cost effectiveness studies. These evidences, the similar risk of HIV transmission for certain non-occupational exposures to occupational ones, and the conflicting information about attitudes and practices among physicians on NONOPEP led to the proposal of these European recommendations. Participant members of the European project on HIV NONOPEP, funded by the European Commission, and acknowledged as experts in bloodborne pathogen transmission and prevention, met from December 2000 to December 2002 at three formal meetings and a two day workshop for a literature review on risk exposure assessment and the development of the European recommendations for the management of HIV NONOPEP. NONOPEP is recommended in unprotected receptive anal sex and needle or syringe exchange when the source person is known as HIV positive or from a population group with high HIV prevalence. Any combination of drugs available for HIV infected patients can be used as PEP and the simplest and least toxic regimens are to be preferred. PEP should be given within 72 hours from the time of exposure, starting as early as possible and lasting four weeks. All patients should receive medical evaluation including HIV antibody tests, drug toxicity monitoring and counseling periodically for at least 6 months after the exposure. NONOPEP seems to be a both feasible and frequent clinical practice in Europe. Recommendations for its management have been achieved by consensus, but some remain controversial, and they should be updated periodically. NONOPEP should never be considered as a primary prevention strategy and the final decision for prescription must be made on the basis of the patient-physician relationship. Finally, a surveillance system for these cases will be useful to monitor NONOPEP practices in Europe.

[AIDS patients with an unclassified risk factor for HIV]. / Enfermos de SIDA con factor de riesgo del VIH no clasificado.

OBJECTIVES: In the surveillance of the AIDS epidemic via registries there is a small proportion of cases whose route of HIV transmission is unknown (5% for Catalonia, Spain). For reclassification purposes, the aim of this study is to detect similarities between these cases with "not qualified risk" (NQR) with the other main HIV transmission groups. METHODS: All Aids cases (> 12 years) resident in Catalonia and reported between 1988 and 1996 to the AIDS registry (n = 8,559) were compared according to their distribution of "age at diagnosis" and "first indicative AIDS disease". ANOVA and log-linear regression models were applied separately by sex. RESULTS: Evidence of similarity with the NQR group was only found for men; in terms of age at diagnosis, the NQR group was similar to both groups of sexual transmission whilst in terms of Aids indicative disease it was similar to the heterosexual transmission group. As from 1994, a reduction in the incidence of NQR cases was observed and coincided with an increase in the heterosexual group. CONCLUSIONS: According to the characteristics of the NQR cases, it can be concluded that all cases acquired HIV via one of the classic routes of infection, primarily through heterosexual contacts. For this reason, it is advisable that the criteria that define heterosexual HIV transmission be relaxed.

[HIV infection in the alternative centers for voluntary detection of anti-HIV antibodies in Cataluna, Spain (1995-1996). VIHDEVO collaborative group]. / Infección por el VIH en los centros alternativos para la detección voluntaria de los anticuerpos anti-VIH en Cataluña (1995-1996). colaborador VIHDEVO.

OBJECTIVE: The knowledge of HIV serostatus may help the treatment and follow up of those infected people, and change the risky behaviours in those not infected. Epidemiological information from people tested can better address the activities of control and prevention of HIV infection. DESIGN: Collection of demographic and epidemiological information. PARTICIPANTS: People voluntary tested in four alternative test settings in Catalonia. MEASUREMENTS AND MAIN RESULTS: Of 1,733 petitions of voluntary testing, 63 (3.7%) were HIV positive. Overall prevalence in men were two fold than in women (4.6% vs 2.3%). In both years of study, the mean age for women HIV positive were higher than the mean age for women with aids. CONCLUSIONS: The results of this study confirm the age and sex pattern found for the HIV infection in other sentinel populations in Catalonia. Some measures should be taken in order to increase the accessibility of young women to the test.

[Extension of reporting AIDS cases in Catalonia: study based on requests for CD4 lymphocyte count and prescription of antiretroviral drugs]. / Exhaustividad de la notificación de los casos de SIDA en Cataluña: un estudio basado en las solicitudes de determinaciones de linfocitos CD4 y en la prescripción de antirretrovirales.

BACKGROUND: To ascertain the degree to which AIDS is officially reported in Catalunya. METHOD: The request for T CD4+ white blood cell counts and the prescribing of antiretroviral drugs in seven university hospitals in Catalunya from January 1, 1994 to June 31, 1994 were used as data-comparison sources. A case was considered to not have been reported when the clinical history showed a diagnosis of AIDS (according to the Europe 93 definition) and the case in question did not show up on the AIDS Registry for Catalunya. RESULTS: Of the 1,370 cases studied, 50 unreported AIDS cases were found. In all, 98.6% of all cases were found to have been reported, for a 95% confidence interval (95% CI): 98.2-99.0. Most of the unreported cases were males (72%) averaging 37.3 years of age (HCA: 11.8), 52% of whom were injected drug users (IDU's), extrapulmonary tuberculosis being the disease most often diagnosed (16%), 81.4% having been found to have a T CD4+ white blood cell count of 200 WBC/mm3 or below. 92% of these cases were detected based on T CD4+ white blood cell counts. CONCLUSIONS: The degree of completeness found is considered to be adequate. It is recommended that the white blood cell count records being used for this type of studies.

[The impact of AIDS in the global mortality in Catalonia, 1981-1993]. / Impacto del sida en la mortalidad global de Cataluña, 1981-1993.

OBJECTIVES: To compare the evolution of the principal causes of death in Catalonia, Spain and to assess the impact of AIDS as a contributing factor to the increase of mortality in young people in Catalonia. METHODS: Data from the mortality register of Department of Health in Catalonia has been used. We have compared the principal causes of death in Catalonia for the global population and for the group of 20 to 39 year olds. We have calculated the potential years of life lost (PYLL) between the ages of 13 to 65. RESULTS: Since the first case of AIDS in 1981, AIDS has been the cause of death with the most important increase for the global population in Catalonia. AIDS is the sixth cause of death and the first cause of PYLL. For the young population in Catalonia (aged 20-39) AIDS became, in 1993, the first cause of death. From 1992 to 1993 the PYLL due to AIDS increased 5% in men and 51% in women. CONCLUSIONS: The present situation has led AIDS being the first cause of death among young population. The collaboration between mortality registers and AIDS registers is absolutely essential to assess more accurately the impact of AIDS on the mortality of population.

[Short-term prediction of cases of AIDS in Catalonia (1991-1994)]. / Predicción a corto plazo de los casos de SIDA en Cataluña (1991-94).

Predicting AIDS incidence is a useful strategy for health service planning and for the design of preventive and control programmes. The different predictive mathematical models of AIDS can be classified in simple and complex, according to the assumptions used. The present study presents the prediction of the minimum AIDS incidence in Catalonia for the period 1991-94 by means of three simple mathematical models. The models that have been compared are the projection method of Chin and Lwanga, the retroprojection method of Brookmeyer and Gail, and the extrapolation method of Cox and Medley. Baseline information about AIDS cases comes from the AIDS Registry of the "Generalitat" of Catalonia. In a comparable manner, the three methods point out an increase of AIDS incidence until 1994, varying from 1160 to 1733 new cases in that year depending on the method used. We conclude that it will be necessary to increase the provision of health, social and preventive resources against AIDS in Catalonia in the coming years.

Premature mortality related to AIDS among men and women in Catalonia.

OBJECTIVES: To evaluate the mortality pattern observed in relation to the AIDS epidemic, and to estimate the current and future demographic impact of AIDS among the population aged between 20 and 39 years in Catalonia, Spain. DESIGN: Spain has the highest cumulative incidence rate of AIDS in Europe. One-third of Spanish AIDS cases have been consistently reported from Catalonia, an autonomous region in northeastern Spain with a population of 6 million, and with Pattern I HIV transmission. In this study data from the population-based AIDS registry and death certificates in Catalonia were used. METHODS: Since 1981 AIDS data have been collected routinely from all hospitals using an active surveillance system. All causes of death are coded from death certificates (ICD-9). Mortality rates since 1981 were analysed by age and sex. To assess the relative importance of premature mortality due to AIDS, years of potential life lost (YPLL) before age 65 were used. RESULTS: Since 1982 there has been a continuous increase in crude mortality rates, particularly significant for men aged 20-39 years after 1986 (F < 0.001). While AIDS was the fourth most likely cause of death among people aged 20-39 years in 1988, by 1991 it was the second most likely. In 1990 AIDS contributed to 13,213 YPLL (8.7%) for men and 2579 YPLL (4%) for women. During the last few years AIDS-related deaths have had the highest mortality rate progression among young adults. CONCLUSION: According to the current available data, AIDS might become the leading cause of death for the population aged 20-39 years in the near future. AIDS is having an important impact on the demography of European countries with Pattern I transmission and high HIV prevalence rates.

[Vertical transmission of HIV: descriptive epidemiology, risk factors and survival (II)]. / Transmisión vertical del VIH: epidemiología descriptiva, factores de riesgo y supervivencia (II).

Up until November 30, 1990, 415 children born to HIV-positive mothers were followed in order to study the vertical transmission rate and the survival of those infected, as well as the associated risk factors. According to CDC criteria, 264 children could be considered definitely classified, with 82 classified as infected (transmission rate: 31.1%) and 182 as sero-negative. The remaining 151 infants were younger than 15 months and classified as PO. Ninety percent of the studied mothers were infected through either the use of intravenous drugs or by sexual intercourse with HIV infected partner. The loss-of-antibody median age was one year. The median for the incubation period was 285 days, with a significant bimodal distribution regarding the child's age at diagnosis. Although the median survival time was longer than the study period, the fatality rate was estimated to be 22.0% and the percentage of children reaching age 4, 27%.

[Vertical transmission of HIV infection: descriptive epidemiology, risk factors and survival]. / Transmisión vertical del VIH: epidemiología descriptiva, factores de riesgo y supervivencia (I).

The basic epidemiological characteristics of HIV infection and AIDS among children are described with a particular reference to HIV vertical transmission. The HIV transmission pattern identified in our community is described according to the WHO classification scheme. To describe the epidemic, as well as its temporal evolution, 1.933 cases reported to the population based registry of Catalonia and 287 seropositive children and their mothers are used. We have quantified the importance of intravenous drug usage by the parents in relationship to HIV transmission; 54.7% of the mothers of HIV positive children were intravenous drug users. We predict that during the coming years there will be a continuous increase in AIDS cases as a result of vertical transmission.