Pregnancy affects morphology of induced endometriotic lesions in a mouse model through alteration of proliferation and angiogenesis.

OBJECTIVE: Pregnancy is known to alleviate the symptoms of endometriosis and is also known to be a pro-angiogenic condition affecting blood and lymphatic vessels. However, angiogenesis actively participates in the development of endometriosis. The objective of our study was to study the impact of pregnancy on endometriotic tissue. Study design We performed a cross-sectional, control versus treatment study in a mouse model of endometriosis. Thirty-one female C57Bl6 mice were mated and became pregnant and 31 females were not mated and served as control. Intraperitoneal endometriotic lesions were surgically induced in C57Bl6 mice which were subsequently mated or not (group P: pregnant, group NP: non-pregnant). P and NP mice were sacrificed on day E15.5 of the pregnancy of P mice and lesions were harvested. Lesions were weighed and analyzed by histology, immunohistology, flow cytometry and real-time quantitative RT-PCR (qRT-PCR). RESULTS: Pregnancy reduced lesion weight, decreased the proportion of cystic component (0.02 vs. 0.4; p<0.001) and modified the architecture of peritoneal endometriotic lesions. Pregnancy also increased cell proliferation in both stromal and glandular tissue as shown by the increase in Ki 67-positive cells in the P group (glandular: 19 vs. 3.9%, p<0.001; stromal: 8.7 vs. 3.3%, p<0.01). Finally, pregnancy increased angiogenesis in endometriotic lesions as indicated by an increased microvessel density (CD-31 and LYVE-1 stainings: respectively 2.2 vs. 5.1%, p<0.01 and 0.4 vs. 0.9%, p<0.001), an increased number of LYVE1 positive cells evaluated by flow cytometry (18.9 vs. 4.6%, p<0.05) and a rise in VEGF-A, -R2 and -R3 RNA expression shown by qRT-PCR (p<0.001; p<0.01; p<0.05). CONCLUSION: These challenging results provide insight in understanding the pathophysiology of endometriosis and evoke a correlation between lesion architecture and symptomatology.

La medición de la Inteligencia Emocional en adolescentes españoles con trastorno de ansiedad / The Measurement of Perceived Emotional Intelligence for Spanish Adolescents with Social Anxiety Disorder Symptoms

La Inteligencia Emocional (IE) es un concepto que ha sido discutido durante décadas en Psicología pero no ha recibido apoyo empírico hasta hace pocos años, a pesar de ello parece que en las últimas décadas es-te concepto está suscitando mucho interés entre las diversas áreas de la Psicología. Con este creciente interés, el concepto de percepción de la Inteligencia Emocional está recibiendo mayor atención. Debido a interés mostrado en este concepto, este artículo tiene como objetivo explorar dos aspectos importantes del mismo: la medida de la percepción de la IE y las implicaciones que la percepción de la IE puede tener en adolescentes con un trastorno de Ansiedad Social (TAS). Este estudio explora un cuestionario muy utilizado para evaluar el PEI, llamado Trait Meta-Mood Scale (TMMS). La versión española reducida de dicho cuestionario (TMMS-24) y una serie de cuestionarios muy utilizados para evaluar el TAS fueron administrados a 425 adolescentes españoles. Los resultados del estudio corroboraron que el TMMS-24 posee buenas propiedades psicométricas en adolescentes y que el componente de regulación emocional parece que está involucrado en la ansiedad social (AU)

Emotional Intelligence (EI) is a concept that has been discussed for decades in Psychology but has received very little empirical study until recently. And with this growing interest, its accompanying concept, Perceived Emotional Intelligence (PEI), has also received more attention. It is due to this growing interest in PEI that this paper explores two important aspects of the PEI: the measurement of PEI and the implications PEI may have for adolescent anxiety disorder symptomology. This study explores a well-known questionnaire of PEI, namely the Trait Meta-Mood Scale questionnaire (TMMS). The Spanish shortened version of the Trait Meta-Mood Scale questionnaire (TMMS-24) and a series of well-known questionnaires of Social Anxiety Disorder symptomology were administrated to 425 Spanish high-school adolescents. The results of this study corroborated that the TMMS-24 has good psychometric properties in adolescents, and that one of its three scales (Emotional Repair) appears to be involved in adolescent SAD symptomology (AU)

Psychometric properties of the screen for child anxiety related emotional disorders for socially anxious and healthy Spanish adolescents.

Socially anxious and healthy Spanish adolescents were studied in order to test the psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED). Confirmatory factor analyses were employed to test measurement invariance between these two populations, Cronbach's alphas were calculated to determine the reliabilities of the scales, and partial eta-square tests calculated the effect size of the differences between socially anxious and healthy adolescents and between the adolescent boys and girls. The psychometric properties of the SCARED were good, as demonstrated by having acceptable reliabilities (ranging from .75 - .41) and a moderate multivariate effect size (η(p)(2) = .08) between the adolescent boys and girls. Most importantly, it was demonstrated that the SCARED could differentiate between socially anxious and healthy Spanish adolescents as demonstrated by measurement invariance (χ(2) = 254.27, df = 1343, GFI = .884, AGFI = .872, RMR = .031) and the large effect size (η(p)(2) = .22) between the samples.

Psychometric properties of the screen for child anxiety related emotional disorders for socially anxious and healthy Spanish adolescents

Socially anxious and healthy Spanish adolescents were studied in order to test the psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED). Confirmatory factor analyses were employed to test measurement invariance between these two populations, Cronbach’s alphas were calculated to determine the reliabilities of the scales, and partial eta-square tests calculated the effect size of the differences between socially anxious and healthy adolescents and between the adolescent boys and girls. The psychometric properties of the SCARED were good, as demonstrated by having acceptable reliabilities (ranging from .75 - .41) and a moderate multivariate effect size (çp2 = .08) between the adolescent boys and girls. Most importantly, it was demonstrated that the SCARED could differentiate between socially anxious and healthy Spanish adolescents as demonstrated by measurement invariance (÷2 = 254.27, df = 1343, GFI = .884, AGFI = .872, RMR = .031) and the large effect size (çp2 = .22) between the samples (AU)

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