RESUMO
We describe the cytogenetic study of two basal cell carcinomas. Only single chromosomally abnormal clones could be detected in both. In addition, many nonclonal changes were seen in the samples, which may represent small neoplastic clones or the result of a basic molecular defect induced by carcinogens.
Assuntos
Carcinoma Basocelular/genética , Aberrações Cromossômicas/genética , Neoplasias Cutâneas/genética , Idoso , Feminino , Humanos , Cariotipagem , Masculino , Pessoa de Meia-IdadeRESUMO
The purpose of this study was to isolate fungi from the quarter milk of cow udders from several dairy herds and to identify the different genera and species involved in mastitis. A total of 2078 milk samples from normal, clinical and subclinical mastitis quarters from 22 dairy herds of 16 districts in the State of São Paulo, Brazil was utilized in this survey. Two hundred and fifty one (12.07%) fungi were isolated from the samples. Two hundred and eight of these (82.86%) were yeasts and 30 (11.95%) were moulds. The fungi were isolated in pure culture (24.77%) or in cultures mixed with bacteria (72.22%). The yeasts isolated were: Cryptococcus spp. (71 strains), Rhodotorula spp. (40), Candida spp. (68), Trichosporon cutaneum (21), Aureobasidium pullulans (7), and Pichia ohmeri (1). Moulds classified in following genera were also isolated: Aspergillus (3), Penicillium (3), Alternaria (3), Phoma (3), Epicoccum (2), and Geotrichum (16).
Assuntos
Fungos/isolamento & purificação , Mastite Bovina/microbiologia , Leite/microbiologia , Micoses/veterinária , Animais , Brasil/epidemiologia , Bovinos , Feminino , Fungos/classificação , Glândulas Mamárias Animais/microbiologia , Mastite Bovina/epidemiologia , Técnicas de Tipagem Micológica , Micoses/epidemiologia , Micoses/microbiologiaRESUMO
Chromosome analysis of short-term cultures from a basal cell carcinoma was performed. The analyzed karyotypes showed a pseudodiploid clone characterized by a der(4)t(4;14) (p14;p11) and a concomitant inversion of the same chromosome 4 involved in the t(4;14) with the breakpoints at p14 and q25.
Assuntos
Carcinoma Basocelular/genética , Aberrações Cromossômicas , Cromossomos Humanos Par 14 , Cromossomos Humanos Par 4 , Neoplasias Nasais/genética , Inversão Cromossômica , Feminino , Humanos , Cariotipagem , Pessoa de Meia-Idade , Translocação Genética , Células Tumorais CultivadasRESUMO
Chromosome analysis of short-term culture of a basal cell carcinoma showed five clonal chromosome abnormalities, t(9;14)(q12 or q13;p11), del(1)(q23 or q25), trisomy 5, trisomy 7, and monosomy X. In addition, several nonclonal structural and numerical changes were seen in the tumor cells.