Association between the Processed Dietary Pattern and Tumor Staging in Patients Newly Diagnosed with Head and Neck Squamous Cell Carcinoma.

PURPOSE: This study aimed to assess the association between dietary patterns and tumor staging and the degree of cell differentiation in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: This cross-sectional study included 136 individuals newly diagnosed with different stages of HNSCC, aged 20- to 80 years-old. Dietary patterns were determined by principal component analysis (PCA), using data collected from a food frequency questionnaire (FFQ). Anthropometric, lifestyle, and clinicopathological data were collected from patients' medical records. Disease staging was categorized as initial stage (stages I and II), intermediary (stage III), and advanced (stage IV). Cell differentiation was categorized as poor, moderate, or well-differentiated. The association of dietary patterns with tumor staging and cell differentiation was evaluated using multinomial logistic regression models and adjusted for potential confounders. RESULTS: Three dietary patterns, "healthy," "processed," and "mixed," were identified. The "processed" dietary pattern was associated with intermediary (odds ratio (OR) 2.47; 95% confidence interval (CI) 1.43-4.26; p = 0.001) and advanced (OR 1.78; 95% CI 1.12-2.84; p = 0.015) staging. No association was found between dietary patterns and cell differentiation. CONCLUSION: A high adherence to dietary patterns based on processed foods is associated with advanced tumor staging in patients newly diagnosed with HNSCC.

Obesity and diet contents of protein and fat are associated with underreport of energy at pregnancy / Obesidade e conteúdo de proteína e gordura na dieta estão associados ao sub-relato do consumo energético na gravidez

Abstract Objectives: to evaluate the association of pre-pregnancy and current body mass index and the density of dietary macronutrients on underreporting of energy intake at pregnancy. Methods: cross-sectional analysis of 327 postpartum women from the city of Mesquita, in Rio de Janeiro. A food frequency questionnaire was administered at maternity ward having the last six months of the pregnancy as the time frame. Energy balance was considered as the outcome, and it was calculated as the division of energy intake by basal metabolic rate (underreport <1.35). Multivariate logistic regression was applied to test the associations between body mass index (pre-gestational and postpartum) on energy balance (underreport or not). Dietary density of protein (4th quartile), carbohydrate (1st quartile) and fat intake (1st quartile) were tested. Results: mean energy intake was 2,894 kcal and near of 25% of the women were considered as underreported during pregnancy. Obese women had higher chance (OR=1.90; CI95%=1.09-3.33) of being underreported at pregnancy. Underreported women presented greater chance of report dietary intake with higher contents of protein (OR=2.37; CI95%=1.37-4.09) and lower density of fat (OR= .81; CI95%=1.04-3.15). Conclusion: underreported pregnant women had higher chance of report great and lower amounts of protein and fat dietary densities.

Resumo Objetivos: avaliar a associação entre o índice de massa corporal pré-gestacional e pós-parto e a densidade de macronutrientes da dieta com o sub-relato de energia da dieta na gestação. Métodos: análise transversal com 327 puérperas da cidade de Mesquita, no Rio de Janeiro. Aplicou-se o questionário de frequência alimentar na primeira semana após o parto tendo como base o consumo dos dois últimos trimestres gestacionais. O balanço energético foi calculado a partir da divisão da ingestão de energia pela taxa metabólica basal (sub-relato<1,35). Adotou-se a regressão logística multivariada para analisar as associações entre os índices de massa corporal e a densidade dos macronutrientes da dieta (proteína, carboidratos e lipídios) com o balanço energético (sub-relato ou não). Resultados: a ingestão média de energia foi de 2.894 kcal e 25% das mulheres foram classificadas com sub-relato. Mulheres obesas no pós-parto tiveram maiores chances (OR=1,90; IC95%=1,09-3,33) de sub-relato de energia na gravidez e gestantes com balanço energético <1,35 apresentaram dieta com maior densidade de proteína (OR=2,37; IC95%=1,37-4,09) e menor densidade de gordura (OR=1,81; IC95%=1,04-3,15). Conclusão: a obesidade no pós-parto foi associada ao sub-relato de energia na gravidez e o balanço energético associou-se a densidade dos macronutrientes da dieta

Association between the consumption of sugar-sweetened beverages and food markers: National Dietary Survey 2008-2009 / Associação entre o consumo de bebidas adoçadas e marcadores da alimentação: Inquérito Nacional de Alimentação 2008-2009

Abstract We aimed to analyze the association between sugar-sweetened beverage (SSB) consumption with healthy food markers (HFM) and unhealthy food markers (UFM) as well as their impact on these markers in the Brazilian population's diet. Food consumption during two nonconsecutive days of food records of individuals aged ten years or over were investigated in the National Dietary Survey 2008-2009 (n = 32,900) and the caloric contributions of HFM and UFM were distributed according to the categories of SSB consumption. Multiple linear regression was applied to analyze the associations between the consumption of SSB and the impact of a 50% reduction in portion size and dietary markers. The contribution of energy from HFM was higher among individuals who did not consume SSB. A 50% reduction in the average portion of SSB in the population would imply a 6% decrease in energy contribution to the diet and 12% decrease in total energy from added sugar. It would increase the consumption of HFM and dietary fiber by 7g and 4g, respectively. A 50% reduction in SSB serving size is a strategy that could improve the quality of the diet, increase the consumption of HFM and fiber and reduce the consumption of sugar and UFM.

Resumo Analisar a associação entre o consumo de bebidas adoçadas (BA) e marcadores da alimentação saudável ​​(MAS) e não saudável ​​(MANS), bem como seu impacto sobre esses marcadores na dieta da população brasileira. Os dados de consumo alimentar foram analisados ​​por meio de registros alimentares de dois dias não consecutivos em indivíduos com 10 anos ou mais de idade investigados no Inquérito Nacional de Alimentação (INA) de 2008-2009 (n = 32.900). As BA, as contribuições calóricas dos MAS e MANS foram distribuídas de acordo com as categorias de consumo das BA. A regressão linear múltipla foi aplicada para analisar associações entre o consumo de BA e o impacto de uma redução de 50% no tamanho da porção e marcadores da alimentação. A contribuição da energia dos MAS foi maior entre os indivíduos que não consumiam BA. A redução de 50% na porção média das BA na população implicaria uma diminuição de 6% na contribuição de energia da dieta, de 12% na energia total do açúcar de adição e teria um aumento no consumo de MAS e fibra alimentar em 7g e 4g, respectivamente. A redução de 50% no tamanho da porção das BA seria uma estratégia para melhorar a qualidade da dieta, aumentar o consumo de MAS e fibra e reduzir o consumo de açúcar e MANS.

Gestational weight gain and adverse maternal and perinatal outcomes among women with gestational diabetes mellitus according to International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria: A cross sectional study.

AIMS: To evaluate the association of gestational weight gain and adverse maternal and perinatal outcomes among Brazilian women with gestational diabetes mellitus (GDM). METHODS: Cross-sectional study conducted in women with GDM, and their newborns, who attended a public maternity hospital. The Institute of Medicine criteria were adopted to assess adequacy of gestational weight gain (GWG). Cesarean delivery, maternal hypertensive disorders of pregnancy (HDP), premature birth, macrosomia, and birth weight adequacy for gestational age were analyzed as outcomes. Simple and multiple logistic regression models were tested to assess the effect of adequacy of GWG on maternal and newborn outcomes. RESULTS: Among the 545 women studied, 64.2% (n = 344) had inadequate weight gain: 27.2% (n = 146) insufficient and 37% (n = 198) excessive. Women with insufficient GWG were more likely to have a preterm birth (OR 2.57; 95% CI: 1.06-6.19), while those with excessive GWG had a greater chance of HDP (OR 2.62; 95% CI: 1.54-4.45) and large for gestational age newborn (OR 1.88; 95% CI: 1.08-3.29), compared with those with adequate weight gain. CONCLUSIONS: Inadequate gestational weight gain was frequent in women with GDM, especially in pregnant women with overweight and obesity, and is associated with unfavorable outcomes.

Association between the consumption of sugar-sweetened beverages and food markers: National Dietary Survey 2008-2009.

We aimed to analyze the association between sugar-sweetened beverage (SSB) consumption with healthy food markers (HFM) and unhealthy food markers (UFM) as well as their impact on these markers in the Brazilian population's diet. Food consumption during two nonconsecutive days of food records of individuals aged ten years or over were investigated in the National Dietary Survey 2008-2009 (n = 32,900) and the caloric contributions of HFM and UFM were distributed according to the categories of SSB consumption. Multiple linear regression was applied to analyze the associations between the consumption of SSB and the impact of a 50% reduction in portion size and dietary markers. The contribution of energy from HFM was higher among individuals who did not consume SSB. A 50% reduction in the average portion of SSB in the population would imply a 6% decrease in energy contribution to the diet and 12% decrease in total energy from added sugar. It would increase the consumption of HFM and dietary fiber by 7g and 4g, respectively. A 50% reduction in SSB serving size is a strategy that could improve the quality of the diet, increase the consumption of HFM and fiber and reduce the consumption of sugar and UFM.

Association between maternal dietary intake classified according to its degree of processing and sex-specific birth weight for gestational age / Associação entre o consumo alimentar materno na gravidez de acordo com o grau de processamento e peso ao nascer segundo a idade gestacional e sexo

ABSTRACT Objective To assess the association between the maternal diet, according to the degree of processing of food consumption, and birth weight for gestational age and sex. Methods A cross-sectional study with 300 women was conducted from February 2009 to 2011 from a maternity ward in Mesquita, Rio de Janeiro. The outcome was based on sex-specific birth weight for gestational age: small, adequate, or large. A validated food frequency questionnaire was used to estimate the food consumption during the 2nd and 3rd trimesters of pregnancy. The food intake was classified into three groups according to the degree of processing: 1) unprocessed or minimally processed foods and culinary ingredients (oil, fats, salt, and sugar), 2) processed foods, and 3) ultra-processed foods. Descriptive analyses were made to assess the tertiles of the percentage of energy intake of each food group on the outcome and on maternal and infant characteristics. Multinomial logistic regressions were used to test the association of the tertiles of food according to the degree of processing on the outcome (adequate, small, or large birth weight for gestational age and sex). Results The analysis of the food frequency questionnaire from the 300 women indicated that the mean percentage of kcal consumed from unprocessed and minimally processed food and culinary ingredients was 54.0%, while the percentages of energy from processed foods and ultra-processed foods were 2.0% and 44.0%, respectively. The highest tertile of consumption of unprocessed and minimally processed food and culinary ingredients had a protective effect on the prevalence of newborn large for gestational weight in relation to the lowest (OR: 0.13; 95% IC: 0.02 to 0.89; p=0.04). Conclusion High consumption of unprocessed and minimally processed food and culinary ingredients during the last six months of pregnancy might be a protective factor against having a newborn large for gestational weight when compared to mothers with the lowest consumption.

RESUMO Objetivo Avaliar a associação da dieta materna de acordo com o grau de processamento dos alimentos e o peso ao nascer segundo a idade gestacional e sexo. Métodos Estudo transversal com 300 mulheres captadas entre os meses de fevereiro de 2009 e 2011. Utilizou-se a classificação do peso ao nascer segundo sexo e idade gestacional para caracterizar os desfechos: pequeno, adequado ou grande. O questionário de frequência alimentar estimou o consumo durante o 2º e 3º trimestres da gestação. Os alimentos foram classificados segundo o grau de processamento: 1) alimentos in natura ou minimamente processados e ingredientes culinários (óleos, gordura, sal e açúcar), 2) alimentos processados e 3) alimentos ultraprocessados. Os tercis de energia das categorias descritas acima foram distribuídos segundo o desfecho e as características maternas e do recém-nascido. Adotou-se a regressão logística multinomial para analisar a associação do consumo de alimentos segundo o grau de processamento sobre os desfechos do peso ao nascer segundo a idade gestacional e o sexo (pequeno, adequado ou grande). Resultados A análise do questionário de frequência do consumo alimentar das 300 mulheres indicou que a contribuição de alimentos in natura ou minimamente processados e ingredientes culinários foi de 54,0%, enquanto que os percentuais dos grupos de alimentos processados e ultraprocessados foram 2,0% e 44,0%, respectivamente. O maior tercil de alimentos in natura ou minimamente processados e ingredientes culinários obteve efeito protetor para a prevalência de recém-nascidos grandes para a idade gestacional e o sexo em relação ao menor tercil (OR: 0,13; IC 95%: 0,02;0,89; p=0,04). Conclusão O maior consumo de alimentos in natura ou minimamente processados e ingredientes culinários durante a gestação pode ser um fator de proteção contra a ocorrência de recém-nascidos grandes para a idade gestacional e o sexo quando comparado com mães classificadas no menor tercil de consumo.

Associação entre a Assistência Pré-Natal e o Ganho de Peso Gestacional: Estudo Seccional em uma Área de Baixa Renda do Rio de Janeiro / Association between Prenatal Care and Gestational Weight Gain: Cross-Sectional Study in a Low-Income Area of Rio de Janeiro

Objetivo: Verificar a associação entre a adequação da assistência pré-natal e o ganho de peso gestacional (GPG) em puérperas brasileiras de baixa renda. Métodos: Estudo transversal no município de Mesquita-RJ, incluindo 281 mulheres no pós-parto imediato. O GPG foi classificado como adequado, insuficiente e excessivo de acordo com as recomendações do Institute of Medicine (IOM). O número de consultas do prénatal foi categorizado (1: nenhuma consulta; 2: 1-3 consultas; 3: 4-6 consultas; 4: 7 ou mais consultas) e o início do pré-natal, segundo as semanas gestacionais (SG), foi utilizado como variável contínua. A assistência pré-natal (AP) avaliou as duas dimensões agrupadas do Índice de Kotelchuck: adequado (adequado + mais adequado) ou inadequado (intermediário e inadequado). Modelos de regressão logística multinomial foram utilizados para estimar as associações entre assistência pré-natal inadequada e GPG. Resultados: AP foi iniciada em média com 12,6 (± 6,9) SG; 8,2% das mulheres (n = 23) fizeram ≤ 4 consultas de pré-natal e 38,4% (n = 108) foram classificadas com AP inadequada. Em média, o GPG foi de 12,9 kg (± 6,2) e 36,5%, 31,0% e 32,5% das mulheres apresentaram GPG adequado, insuficiente e excessivo, respectivamente. Após o ajuste, a inadequação da AP (OR = 2,01; IC 95% = 1,03-3,90) foi associada a uma maior probabilidade de GPG abaixo das recomendações do IOM. Conclusão: Observou-se uma associação significativa entre a inadequação da assistência pré-natal e o GPG insuficiente, o que reforça a relevância da adequada AP para monitorar o adequado GPG e intervir precocemente na gestação

Aim: To investigate the association between the adequacy of prenatal care and gestational weight gain (GWG) among low-income Brazilian postpartum women. Methods: Cross-sectional study in the city of Mesquita, Rio de Janeiro state, including 281 low-income adult Brazilian postpartum women. GWG was categorized as adequate, insufficient and excessive according to the Institute of Medicine (IOM) recommendations. The number of prenatal visits was categorized (1: no visit; 2: 1-3 visits; 3: 4-6 visits; 4: 7 or more visits) and gestational week (GW) at the onset of prenatal care (prenatal initiation) was used as a continuous variable. Prenatal care (PC) evaluated both grouped dimensions of the Kotelchuck's Index: adequate (adequate + adequate plus) or inadequate (intermediate and inadequate). Multinomial logistic regression models were performed to estimate the associations between inadequate prenatal care and GWG. Results: PC started at 12.6 (± 6.9) GW; 8.2% of women (n=23) had ≤ 4 prenatal visits and 38.4% (n=108) had inadequate PC. On average, GWG was 12.9 kg (±6.2) and 36.5%, 31.0% and 32.5% of women presented adequate, insufficient and excessive GWG, respectively. After adjustment, the inadequacy of PC (OR=2.01; CI 95%=1.03-3.90) was associated with an increased likelihood of gaining weight below IOM recommendations. Conclusion: This study found a significant association between the inadequacy of prenatal care and insufficient GWG, which reinforces the relevance of having adequate PC to provide the opportunity for identification of inadequate GWG and early intervention at pregnancy.

Correction to: Calcium and vitamin D supplementation and/or periodontal therapy in the treatment of periodontitis among Brazilian pregnant women: protocol of a feasibility randomised controlled trial (the IMPROVE trial).

An amendment to this paper has been published and can be accessed via the original article.

Calcium and vitamin D supplementation and/or periodontal therapy in the treatment of periodontitis among Brazilian pregnant women: protocol of a feasibility randomised controlled trial (the IMPROVE trial).

BACKGROUND: Periodontitis is a common oral inflammation, which is a risk factor for adverse pregnancy outcomes. Intakes of vitamin D and calcium are inversely associated with occurrence and progression of periodontitis. This study aims to assess the feasibility of a multi-component intervention, including provision of milk powder supplemented with calcium and vitamin D and periodontal therapy (PT), for improving maternal periodontal health and metabolic and inflammatory profiles of low-income Brazilian pregnant women with periodontitis. METHODS: The IMPROVE trial is a feasibility randomised controlled trial (RCT) with a 2 × 2 factorial design with a parallel process evaluation. Pregnant women with periodontitis, aged 18-40 years and with < 20 gestational weeks (n = 120) were recruited and randomly allocated into four groups: (1) fortified sachet (vitamin D and calcium) and powdered milk plus PT during pregnancy, (2) placebo sachet and powdered milk plus PT during pregnancy, (3) fortified sachet (vitamin D and calcium) and powdered milk plus PT after delivery and (4) placebo sachet and powdered milk plus PT after delivery. Dentists and participants are blinded to fortification. Acceptability of study design, recruitment strategy, random allocation, data collection procedures, recruitment rate, adherence and attrition rate will be evaluated. Data on serum levels of vitamin D, calcium and inflammatory biomarkers; clinical periodontal measurements; anthropometric measurements; and socio-demographic questionnaires are collected at baseline, third trimester and 6-8 weeks postpartum. Qualitative data are collected using focus group, for analysis of favourable factors and barriers related to study adherence. DISCUSSION: Oral health and mineral/vitamin supplementation are much overlooked in the public prenatal assistance in Brazil and of scarcity of clinical trials addressing these issues in low and middle-income countries,. To fill this gap the present study was designed to assess the feasibility of a RCT on acceptability of a multi-component intervention combining conventional periodontal treatment and consumption of milk fortified with calcium-vitamin D for improving periodontal conditions and maternal metabolic and inflammation status, among Brazilian low-income pregnant women with periodontitis. Thus, we hope that this relatively low-cost and safe multicomponent intervention can help reduce inflammation, improve maternal periodontal health and metabolic profile and consequently prevent negative gestational outcomes. TRIAL REGISTRATION: NCT, NCT03148483. Registered on May 11, 2017.

High protein diet promotes body weight loss among Brazilian postpartum women.

There is evidence in the general population that adhering to a high protein and low carbohydrate diet may help in losing weight. However, there is little evidence among postpartum women. The aim of this study is to evaluate the effect of a high protein diet on weight loss among postpartum women. A parallel-randomized controlled trial with 94 postpartum women was conducted in a maternity ward in Mesquita county (recruitment from February 2009 to December 2010) and in a polyclinic in Rio de Janeiro city (recruitment from December 2010 to December 2011). Women were randomized to the intervention group (IG) or control group (CG), and both groups received an isocaloric diet (1,800 kcal). Additionally, the IG received approximately 25 g of protein obtained from 125 g per week of sardine to increase daily dietary protein content and was advised to restrict carbohydrate intake. The CG received nutritional counselling to follow the national nutrition guidelines (15% protein, 60% carbohydrates, and 25% lipids). A linear mixed-effects model was used to test the effect of high protein intake and macronutrient intake on weight loss during the postpartum period. Body weight decreased in the IG compared with the CG (ß = -0.325; p = 0.049) among overweight and obese postpartum women. The percentage of energy intake from lipid (ß = -0.023; p = 0.050) was negatively associated with body weight, and carbohydrate intake (ß = 0.020; p = 0.026) was positively associated with body weight over time among all women. Protein intake and lower carbohydrate intake may be used as a dietary strategy to improve body weight loss during the postpartum period.

Protein intake and weight gain among low-income pregnant women from Mesquita County, Rio de Janeiro, Brazil / Consumo de proteína e ganho de peso entre gestantes de baixa renda do município de Mesquita, Rio de Janeiro, Brasil

ABSTRACT Objective To evaluate the effect of protein intake on body weight gain at pregnancy. Methods A cross-sectional study was carried out with 297 women who delivered a child at the maternity ward of Municipal Hospital Leonel de Moura Brizola in Mesquita city in the state of Rio de Janeiro. Sociodemographic and anthropometric data were collected through the use of a structured questionnaire at first week after delivery. Food intake was assessed by a food frequency questionnaire. Protein intake per kilogram of body weight (g/kg per day) during pregnancy was categorized as high or low protein intake according to overall median levels. Hierarchical multiple linear regression was fitted to estimate the effect of protein intake per kg during pregnancy on weight gain. Results Women presented an average weight gain of 12.8kg (SD=6.34) and 26.8kg/m2 (SD=4.78) of Body Mass Index. Those who consumed a diet with high levels of protein content significantly presented less weight at postpartum (p<0.01) lower Early-Pregnancy Body Mass Index (p<0.01). In the hierarchical linear regression, it was found a negative association of protein intake per kg and Weight gain (b=-4.3025; IC95%=-6.0215; -2.5836; p<0.01). In the final model, all others covariates (energy, schooling, family income and gestational age) were significantly associated with the outcome (p<0.05). The additional model showed a negatively association between Early-Pregnancy Body Mass Index and weight gain (b=-0.2951; IC95%= -0.4987; -0.0915; p<0.01). Conclusion Higher levels of protein intake per kg of body weight during pregnancy were associated with lower weight gain.

RESUMO Objetivo Este estudo teve como objetivo testar a associação entre a ingestão de proteína e o ganho de peso na gestação. Métodos Foi realizado um estudo transversal com 297 mulheres que deram à luz na maternidade do Hospital Municipal Leonel de Moura Brizola, na cidade de Mesquita, situada na baixada do estado do Rio de Janeiro. Os dados sociodemográficos e antropométricos foram coletados na primeira semana após o parto, com base em um questionário estruturado. Aplicou-se um questionário de frequência do consumo alimentar para avaliar a Ingestão de Proteína durante a gravidez, que foi classificada como alta ou baixa de acordo com os valores medianos observados. Adotou-se a regressão hierárquica linear múltipla para estimar o efeito da ingestão de proteína (ptn) por quilograma (kg) sobre o ganho de peso. Resultados As gestantes apresentaram, em média, um ganho de peso de 12,8kg (DP=6,34) e um Índice de Massa Corporal Pré-Gestacional de 26,8kg/m2 (DP=4,78). As gestantes com alta ingestão de proteína apresentaram valores significantemente menores em relação ao peso no pós-parto (p<0,01) e ao Índice de Massa Corporal pré-gestacional (p<0,001). No modelo final, todas as covariáveis (energia, escolaridade, renda familiar e idade gestacional) foram associadas ao desfecho (p<0,05), sendo verificada uma associação negativa entre a ingestão de ptn/kg e o ganho de peso (b=-4.3025; -6.0215; -2.5836 IC95%; p<0,01). No modelo adicional, observou--se uma associação negativa entre o Índice de Massa Corporal Pré-Gestacional e o ganho de peso (b=-4.3025; IC95%=-6.0215; -2.5836; p<0,01). Conclusão A pesquisa concluiu que teores elevados de proteína dietética foram associados com menores valores de ganho de peso na gestação.

Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: a Brazilian cohort.

PURPOSE: To characterize the physiological changes in 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] throughout pregnancy. METHODS: Prospective cohort of 229 apparently healthy pregnant women followed at 5th-13th, 20th-26th, and 30th-36th gestational weeks. 25(OH)D and 1,25(OH)2D concentrations were measured by LC-MS/MS. Statistical analyses included longitudinal linear mixed-effects models adjusted for parity, season, education, self-reported skin color, and pre-pregnancy BMI. Vitamin D status was defined based on 25(OH)D concentrations according to the Endocrine Society Practice Guideline and Institute of Medicine (IOM) for adults. RESULTS: The prevalence of 25(OH)D <75 nmol/L was 70.4, 41.0, and 33.9%; the prevalence of 25(OH)D <50 nmol/L was 16.1, 11.2, and 10.2%; and the prevalence of 25(OH)D <30 nmol/L was 2, 0, and 0.6%, at the first, second, and third trimesters, respectively. Unadjusted analysis showed an increase in 25(OH)D (ß = 0.869; 95% CI 0.723-1.014; P < 0.001) and 1,25(OH)2D (ß = 3.878; 95% CI 3.136-4.620; P < 0.001) throughout pregnancy. Multiple adjusted analyses showed that women who started the study in winter (P < 0.001), spring (P < 0.001), or autumn (P = 0.028) presented a longitudinal increase in 25(OH)D concentrations, while women that started during summer did not. Increase of 1,25(OH)2D concentrations over time in women with insufficient vitamin D (50-75 nmol/L) at baseline was higher compared to women with sufficient vitamin D (≥75 nmol/L) (P = 0.006). CONCLUSIONS: The prevalence of vitamin D inadequacy varied significantly according to the adopted criteria. There was a seasonal variation of 25(OH)D during pregnancy. The women with insufficient vitamin D status present greater longitudinal increases in the concentrations of 1,25(OH)2D in comparison to women with sufficiency.

Maternal dietary patterns during pregnancy and intelligence quotients in the offspring at 8 years of age: Findings from the ALSPAC cohort.

Dietary intake during pregnancy may influence child neurodevelopment and cognitive function. This study aims to investigate the associations between dietary patterns obtained in pregnancy and intelligence quotients (IQ) among offspring at 8 years of age. Pregnant women enrolled in the Avon Longitudinal Study of Parents and Children completed a food frequency questionnaire at 32 weeks' gestation (n = 12,195). Dietary patterns were obtained by cluster analysis. Three clusters best described women's diets during pregnancy: "fruit and vegetables," "meat and potatoes," and "white bread and coffee." The offspring's IQ at 8 years of age was assessed using the Wechsler Intelligence Scale for Children. Models, using variables correlated to IQ data, were performed to impute missing values. Linear regression models were employed to investigate associations between the maternal clusters and IQ in childhood. Children of women who were classified in the meat and potatoes cluster and white bread and coffee cluster during pregnancy had lower average verbal (ß = -1.74; p < .001 and ß = -3.05; p < .001), performance (ß = -1.26; p = .011 and ß = -1.75; p < .001), and full-scale IQ (ß = -1.74; p < .001 and ß = -2.79; p < .001) at 8 years of age when compared to children of mothers in the fruit and vegetables cluster in imputed models of IQ and all confounders, after adjustment for a wide range of known confounders including maternal education. The pregnant women who were classified in the fruit and vegetables cluster had offspring with higher average IQ compared with offspring of mothers in the meat and potatoes cluster and white bread and coffee cluster.

Quality of food choices of Brazilian adolescents according to individual earnings.

OBJECTIVE: To evaluate the quality of food choices according to adolescent individual earnings in Brazil. DESIGN: Adolescents were classified according to their individual earnings as having or not having spending power for their own expenses. Food records from two non-consecutive days of the Brazilian National Dietary Survey (NDS 2008-2009) were used to estimate food intake. Quality of food choices was based on two approaches: (i) the NOVA classification, which classifies processed and ultra-processed foods and drinks as unhealthy food groups; and (ii) traditional classification, with beans, milk, fruits and vegetables as healthy food groups, and soft drinks, sweets, snacks and crackers classified as unhealthy. We compared mean food intake (g/kJ or ml/kJ) according to per capita household income (tertiles) and adolescent individual earnings, with adolescent earnings adjusted for household income, using multiple linear regression. SETTING: Brazilian households (n 13 569). SUBJECTS: Adolescents aged 14-18 years (n 3673). RESULTS: Males without individual earnings had higher per capita household income than those with individual earnings. Household income was associated with all three food groups of the NOVA classification and seven of the eight groups of the traditional classification. However, only beans and snacks were consumed in significantly greater quantities by adolescents with individual earnings compared with those without earnings. CONCLUSIONS: Adolescent individual earnings were not the main driver of food choices; however, per capita household income was associated with food choices. The consumption of both healthy and unhealthy items increased with increasing household income.

Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women.

Plasma concentrations of vitamin D metabolites can be inversely associated with depressive symptoms. However, few longitudinal studies have investigated this association, especially during pregnancy. The aim of this study was to investigate the association between concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxivitamin D [1,25(OH)2D] with the occurrence of depressive symptoms throughout pregnancy. A prospective cohort of 179 women was followed at 5th-13th, 20th-26th and 30th-36th gestational weeks. At each trimester of pregnancy, the plasma concentrations of 25(OH)D and 1,25(OH)2D were analyzed by liquid chromatography tandem mass spectroscopy. Vitamin D status was categorized according to the Endocrine Society Practice Guidelines and the Institute of Medicine. Depressive symptoms were measured at each trimester using the Edinburgh Postnatal Depressive Scale (cutoff ≥13). Statistical analyses included random intercept logistic regression models for longitudinal analyses. In the first trimester, the prevalence of 25(OH)D <75, <50 and <30 nmol/L were 69.3%, 14.0% and 1.7%, respectively. Prevalence of depressive symptoms were 20.1%, 14.7% and 7.8% for the first, second and third trimesters, respectively. The probability of occurrence of depressive symptoms decreased throughout pregnancy (p-value = 0.005). Women with higher concentrations of 25(OH)D in the first trimester presented a lower odds ratio (OR) for the development of depressive symptoms during pregnancy (OR = 0.98; 95%CI: 0.96 to 0.99, p-value = 0.047) in the adjusted model. In conclusion, there was a higher prevalence of vitamin D inadequacy and depressive symptoms during the first trimester. Higher 25(OH)D concentrations in the first trimester were associated with a decrease of 2% in the odds for presenting depressive symptoms throughout pregnancy.

Dietary patterns by cluster analysis in pregnant women: relationship with nutrient intakes and dietary patterns in 7-year-old offspring.

Little is known about how dietary patterns of mothers and their children track over time. The objectives of this study are to obtain dietary patterns in pregnancy using cluster analysis, to examine women's mean nutrient intakes in each cluster and to compare the dietary patterns of mothers to those of their children. Pregnant women (n = 12 195) from the Avon Longitudinal Study of Parents and Children reported their frequency of consumption of 47 foods and food groups. These data were used to obtain dietary patterns during pregnancy by cluster analysis. The absolute and energy-adjusted nutrient intakes were compared between clusters. Women's dietary patterns were compared with previously derived clusters of their children at 7 years of age. Multinomial logistic regression was performed to evaluate relationships comparing maternal and offspring clusters. Three maternal clusters were identified: 'fruit and vegetables', 'meat and potatoes' and 'white bread and coffee'. After energy adjustment women in the 'fruit and vegetables' cluster had the highest mean nutrient intakes. Mothers in the 'fruit and vegetables' cluster were more likely than mothers in 'meat and potatoes' (adjusted odds ratio [OR]: 2.00; 95% Confidence Interval [CI]: 1.69-2.36) or 'white bread and coffee' (OR: 2.18; 95% CI: 1.87-2.53) clusters to have children in a 'plant-based' cluster. However the majority of children were in clusters unrelated to their mother dietary pattern. Three distinct dietary patterns were obtained in pregnancy; the 'fruit and vegetables' pattern being the most nutrient dense. Mothers' dietary patterns were associated with but did not dominate offspring dietary patterns.

High cholesterol dietary intake during pregnancy is associated with large for gestational age in a sample of low-income women of Rio de Janeiro, Brazil.

The association between the quality of maternal dietary fat intake during pregnancy and the infant's birthweight (BW) remains controversial. Our goal was to investigate the association between maternal dietary fat intake during pregnancy and the rate of large for gestational age (LGA) newborns. This study employed a cross-sectional analysis of 297 pairs of mothers/children attending a public maternity at Rio de Janeiro, Brazil. BW for gestational age according to the Intergrowth 21st was defined as follows: adequate for gestational age (AGA ≤ 90th percentile) and LGA (>90th percentile). The statistical analysis was a Poisson regression with robust estimations of the standard errors. Maternal dietary fat intake variables comprised lipids (% total energy); saturated (mg/1000 kcal), monounsaturated (mg/1000 kcal) and polyunsaturated (mg/1000 kcal) fats; and cholesterol (mg/1000 kcal), all of which were obtained with a Food Frequency Questionnaire. The mean BW was 3338 g (SD = 446.9), and the rate of LGA newborns was 13.1%. The mean maternal total energy intake was 2880 kcal (SD = 1074), cholesterol was 154.3 mg/1000 kcal (SD = 68.1) and monounsaturated fat was 6.9 mg/1000 kcal (SD = 2). Mothers of LGA newborns reported higher cholesterol dietary intake (195.8 vs. 148 mg/1000 kcal; P < 0.001), pre-pregnancy body mass index (25.1 vs. 23.5 kg/m2 ; P = 0.026) when compared with mothers of AGA newborns. Women with cholesterol intake within the fourth quartile were 2.48 (95% confidence interval: 1.31-4.66) times more likely to have an LGA infant compared with those in the 1-3 quartiles. Dietary intake of cholesterol during pregnancy influences LGA even after adjusting for other confounders.

Parental dietary patterns and social determinants of children's dietary patterns / Padrões dietéticos dos pais e determinantes sociais dos padrões alimentares das crianças

ABSTRACT Objective To identify dietary patterns in children up to thirty months of age and verify whether they are associated with parental dietary patterns, and socioeconomic and demographic characteristics. Methods This is a cross-sectional study with baseline data from a population-based study composed of 1,085 households from a representative sample of a metropolitan region in Rio de Janeiro, Brazil. The children's food intake was evaluated by two 24-hour recalls, and the dietary patterns were identified by principal component analysis stratified into two groups according to the children's age: 6 to 17 months; and 18 to 30 months. The explanatory variables collected by a structured questionnaire were socioeconomic and demographic characteristics, age at introduction of complementary foods, and parental dietary pattern. A Food Frequency Questionnaire was administered to assess parental dietary pattern, which was determined by principal component analysis. Multivariate linear regression estimated the effect of each explanatory variable on the children's dietary patterns. Results Three dietary patterns were identified in children aged 6-17 months (basic-mixed; mixed-plus; and milk-flours) and two dietary patterns were identified in children aged 18-30 months: basic-mixed and mixed-plus. Multivariate linear regression showed that complementary feeding (b=0.108; p=0.004) was positively associated with the basic-mixed dietary pattern, and family income (b=0.002; p£0.01), with the mixed-plus dietary pattern. A negative association was found between the traditional parental dietary pattern and children's mixed-plus pattern in children aged 6-17 months (b=0.152; p=0.006) and in children aged 18-30 months (b=0.152; p=0.016). In children aged up to 18 months, parental education level (b=0.368; p£0.01) was positively associated with the mixed-plus dietary pattern. Conclusion Family income, parental education level, and parental dietary patterns are associated with children's dietary patterns.

RESUMO Objetivo Identificar os padrões dietéticos entre crianças menores de 30 meses de idade e verificar sua associação com os padrões dietéticos dos pais, juntamente com as características socioeconômicas e demográficas. Métodos Estudo transversal de base populacional composto por amostra representativa de 1.085 domicílios da região metropolitana do Rio de Janeiro. O consumo alimentar infantil foi estimado através de dois recordatórios de 24 horas, aplicados em dias não consecutivos, e os padrões dietéticos foram identificados por análise de componentes principais, estratificada em dois grupos etários (6-17 meses; 18-30 meses). As informações sociodemográficas (idade dos pais, renda familiar, escolaridade e número de moradores no domicílio) e idade da introdução da alimentação complementar foram coletadas a partir de um questionário estruturado. Aplicou-se o Questionário de Frequência do Consumo Alimentar para avaliar o padrão dietético dos pais, gerado através da análise de componentes principais. Empregou-se a regressão linear multivariada para estimar o efeito de cada variável exploratória em relação ao padrão de consumo das crianças. Resultados Três padrões dietéticos foram identificados entre crianças de 6 a 17 meses de idade (básico-misto; misto; e leite e farinhas infantis) e dois entre crianças de 18 a 30 (básico-misto e misto). Os resultados na análise de regressão multivariada mostraram que a idade de introdução da alimentação complementar (b=0.108; p=0.004) foi positivamente associado com o padrão básico-misto e a renda familiar (b=0.002; p£0.01) foi positivamente associada com o padrão misto. Observou-se uma associação negativa entre o padrão alimentar tradicional dos pais e o padrão misto entre as crianças com até 17 meses (b=0.152; p=0.006) e também entre as crianças com idade entre 18 e 30 meses (b=0.152; p=0.016). Entre as crianças maiores de 18 meses, obteve-se uma associação positiva da escolaridade dos pais (b=0.368; p£0.01) e o padrão misto. Conclusão Renda familiar, escolaridade e padrão alimentar dos pais foi associado com os padrões dietéticos das crianças.

Dietary intake variations from pre-conception to gestational period according to the degree of industrial processing: A Brazilian cohort.

OBJECTIVE: To estimate food intake changes from pre-conception to gestational period according to the degree of food processing. METHODS: Prospective cohort conducted in a public health care center in Rio de Janeiro with Brazilian pregnant women (n = 189). A food frequency questionnaire was applied at the first (5(th)-13(th)) and third (30(th)-36(th)) gestational trimesters. The food items were classified according to characteristics of food processing in four groups: unprocessed/minimally processed foods; sugar/fat; processed foods and ultra-processed foods. The variation of food intake according to the degree of processing between the pre-conception and gestational period was compared using paired Student's t-test. Linear regression models were performed to estimate the association of mother's characteristics on the variation of food group contribution to the total energy intake between periods. RESULTS: Total energy intake was 2415 (SD = 813) in the pre-conception and 2379 (750) kcal in the gestational period. We excluded women who had implausible total energy intake (<600 and >6000 kcal/day). The contribution of unprocessed/minimally processed food group to total energy intake during pregnancy when compared to the pre-conception period was higher [50.5 (14.1) vs. 48.8 (12.4), p-value = 0.048], while the caloric share of ultra-processed food group was lower [41.3 (14.6) vs. 43.1 (12.5), p-value = 0.032]. We observed a negative association of age (p-value = 0.009) and a positive association of pre-pregnancy BMI (p-value = 0.060) with the variation of ultra-processed food intake. CONCLUSIONS: Ultra-processed food intake decreased, while minimally/unprocessed food intake slightly increased from the pre-conception to gestational period. These results indicate potential for a larger improvement in the women's diet quality and that nutritional counseling interventions in pregnant women are still needed.

Gestational dietary patterns are not associated with blood pressure changes during pregnancy and early postpartum in a Brazilian prospective cohort.

PURPOSE: To identify gestational dietary patterns and evaluate the association between these patterns and the blood pressure (BP) rate of change during pregnancy and the postpartum. METHODS: Prospective cohort study composed of 191 healthy pregnant women. Systolic BP (SBP) and diastolic BP (DBP) were obtained at the 5th-13th, 20th-26th, 30th-36th gestational weeks, and with 30-45 days postpartum. A food frequency questionnaire administered at the 30th-36th gestational week was used to measure dietary intake during pregnancy. Principal component analysis was performed to identify the dietary patterns. A longitudinal linear mixed-effects regression model was used to evaluate the association between the dietary patterns and BP (adjusted for time elapsed after conception and the women's age, education, parity, body mass index and total energy intake). RESULTS: Three gestational dietary patterns were identified: healthy, common-Brazilian and processed. SBP/DBP mean values (SD) were 110.1 (9.0)/66.9 (7.5), 108.7 (9.0)/64.9 (6.7), 111.3 (9.2)/67.0 (6.9) and 115.0 (10.7)/73.7 (8.6) mmHg at the first, second and third gestational trimesters and postpartum, respectively. Women with higher/lower adherence to the processed pattern presented SBP of 117.9 and 113.0 mmHg (P = 0.037), respectively, during postpartum. No association was found between any of the three dietary patterns and SBP in the multiple longitudinal linear regression models, whereas 1 SD increase in the common-Brazilian pattern was associated with a small change of DBP (ß = 0.0006; 95% CI 4.66e-06, 0.001; P = 0.048). CONCLUSION: The three dietary patterns identified revealed no association with changes of SBP and DBP levels during pregnancy and at early postpartum in this sample of healthy Brazilian women.