Neurotrophic factors and brain health in children with overweight and obesity: The role of cardiorespiratory fitness.

ABSTRACTNeurotrophic factors and cardiorespiratory fitness are both considered important in developmental trajectories but their link to brain health remains poorly understood. The aims of the study were to examine whether levels of plasma-derived neurotrophic factors were associated with brain health indicators in children with overweight or obesity; and to test whether these associations were moderated by cardiorespiratory fitness. 100 children (41% girls) were included in this analysis. Plasma levels of brain-derived neurotrophic factor, insulin-like growth factor-1, vascular endothelial growth factor A, and epidermal growth factor were determined by XMap technology. Academic performance and executive function were assessed using validated neuropsychological tests. Hippocampal volume was measured using magnetic resonance imaging. Cardiorespiratory fitness was assessed using the 20-m Shuttle Run Test. Insulin-like growth factor-1 was positively associated with cognitive flexibility. Stratified analyses by fitness categories (i.e. unfit vs. fit) showed that brain-derived neurotrophic factor was positively associated with right posterior hippocampal volume in fit children, and epidermal growth factor was negatively associated with right hippocampal, and right anterior hippocampal volumes in their unfit peers, with a moderating role of cardiorespiratory fitness in these associations. However, all these significant associations disappeared after correction for multiple comparisons. The association between neurotrophic factors and brain health indicators in children with overweight/obesity was neither strong nor consistent. These results could help enhance our understanding of determinants of brain health in children with overweight/obesity.HighlightsThis study provides novel findings on the associations between neurotrophic factors and a wide range of brain health indicators in children.This study additionally explored the role of cardiorespiratory fitness in these associations.The association between neurotrophic factors and brain health in children with overweight/obesity was neither strong nor consistent.Cardiorespiratory fitness moderated the associations of brain-derived neurotrophic factor and epidermal growth factor with right hippocampal volume.

"Would You Allow Your Wife to Dress in a Miniskirt to the Party"? : Batterers Do Not Activate Default Mode Network During Moral Decisions About Intimate Partner Violence.

Moral convictions consist of assessments based on perceptions of morality and immorality, of right and wrong. There are people who, based on morality, commit crimes. For instance, social and moral norms based on inequality appear to play an important role in the batterer's behavior to commit violent acts. Research shows that batterers consider themselves to be moral persons, are defenders of their beliefs, and, if necessary, are self-delusional, enjoying a "feeling" of moral worth. The main aim of this work was to uncover the brain mechanisms underlying moral decision making related to intimate partner violence (IPV) against women. We conducted a functional magnetic resonance imaging (fMRI) study comparing moral decisions related to IPV and general violence (GV) in a sample of convicted Spanish men. The two groups of our sample were recruited from the Center for Social Insertion (CSI; Granada, Spain): batterers (BG, n = 21), people convicted for IPV, and other criminals (OCG, n = 20) convicted of violating other legal norms without violence against people. Greene's classical dilemmas were used to validate IPV and GV dilemmas. First, our results showed that IPV and GV dilemmas activate the same brain areas as those activated by Greene's dilemmas, primarily involving the default mode network (DMN), which suggests that IPV and GV dilemmas are both moral dilemmas. Second, our results showed that other criminals activated the DMN during both types of dilemmas. Nevertheless, batterers activated the DMN during the GV dilemmas but not during the IPV ones, suggesting that decisions about their female partners do not entail moral conflict. Thus, these preliminary results showed that batterers do not activate moral areas during IPV dilemmas specifically, but do so during GV dilemmas. These results suggest that intervention programs for batterers should aim to specifically modify the value system held by the abuser toward his female partner and not toward other people.

Emotional Regulation in Male Batterers When Faced With Pictures of Intimate Partner Violence. Do They Have a Problem With Suppressing or Experiencing Emotions?

Emotional regulation is crucial to psychological functioning and mental health. Studies of male batterers indicate the critical role that emotional processing plays in the violence they exert upon their partners or ex-partners. The aim of this study was to investigate the neural bases of emotional regulation in male batterers-both in experiencing and suppressing emotions-when faced with pictures of intimate partner violence (IPV). We conducted a fMRI study to compare brain functioning when emotions were experienced or increased with the case in which emotions were suppressed or reduced in response to IPV pictures and unpleasant pictures. The sample consisted of three groups: Male Batterers Group (MBG, n = 26), that is, men convicted for IPV; Other Offenders Group (OOG, n = 27), men convicted of crimes other than IPV; and a Non-offenders Group (n = 29), that is, men without a criminal history. The results reveal that in MBG, the brain areas that previous studies have related to suppression and experience processes were activated when faced with unpleasant pictures. However, a different pattern of functioning was found when experiencing IPV pictures. That could be explained by a low capacity to empathize with their partners or ex-partners and by the use of maladaptive emotional regulation strategies. In addition, MBG showed activation in brain areas previously related to suppression but did not modulate their emotions, showing a similar emotional state after suppression and experience. The results of this preliminary study suggest that in psychological treatments for male batterers, it is important to promote empathy towards partners or ex-partners, along with adaptive strategies of emotional regulation.

Increased Amygdala Activations during the Emotional Experience of Death-Related Pictures in Complicated Grief: An fMRI Study.

Complicated grief (CG) is associated with alterations in various components of emotional processing. The main aim of this study was to identify brain activations in individuals diagnosed with CG while they were observing positive, negative, and death-related pictures. The participants included 19 individuals with CG and 19 healthy non-bereaved (NB) individuals. Functional magnetic resonance imaging (fMRI) scans were obtained during an emotional experience task. The perception of death-related pictures differed between the CG group and the NB group, with a greater activation in the former of the amygdala, putamen, hypothalamus, middle frontal gyrus, and anterior cingulate cortex. Amygdala and putamen activations were significantly correlated with Texas Revised Inventory of Grief scores in the CG group, suggesting that the higher level of grief in this group was associated with a greater activation in both brain areas while watching death-related pictures. A significant interaction between image type and group was observed in the amygdala, midbrain, periaqueductal gray, cerebellum, and hippocampus, largely driven by the greater activation of these areas in the CG group when watching death-related pictures and the lower activation when watching positive-valence pictures. In this study, individuals with CG showed significantly distinct brain activations in response to different emotional images.

Assessment of different components of executive function in grief / Evaluación de diferentes componentes de la función ejecutiva en procesos de duelo

BACKGROUND: Intense and complex symptoms of grief seem to be related to a series of biases and difficulties in areas such as attention, autobiographical memory and problem solving. However, studies of neuropsychological performance have reported contradictory evidence. The role of executive function (EF) in bereaved individuals has not been systematically studied by differentiating between its components. METHOD: A total of 38 participants who had experienced the death of a loved one participated in this study. They were divided into two groups based on the intensity of their symptoms. They underwent neuropsychological assessments that included measures of flexibility, inhibition, working memory and emotional decision-making. RESULTS: Group differences were found in the parts of the emotional decision-making task that assessed decisions made under risk. Considering each participant's level of education and emotional variables, the symptoms of grief predicted a substantial variance in their performance in the decision-making task. CONCLUSION: Intense symptoms of grief seem to be related to poorer emotional decision-making performance but not to flexibility, inhibition or working memory

ANTECEDENTES: los sentimientos y complejos síntomas que pueden asociarse al duelo se han relacionado con dificultades en áreas como la atención, la memoria autobiográfica o la resolución de problemas. Aquellos que han evaluado dimensiones neuropsicológicas han mostrado resultados contradictorios, y el rol de las funciones ejecutivas en población adulta experimentando duelo intenso no ha sido estudiado.MÉTODO: tomaron parte un total de 38 participantes que habían experimentado la muerte de un ser querido. Fueron divididos en dos grupos dependiendo de la intensidad de los síntomas de duelo (altos frente a bajos). Realizaron una evaluación neuropsicológica que incluyó tareas de flexibilidad, inhibición, memoria de trabajo y toma de decisiones emocionales. RESULTADOS: se encontraron diferencias entre los grupos en la toma de decisiones emocionales para aquellos bloques centrados en las decisiones de riego. Controlando por el nivel educativo y los niveles de ansiedad los resultados indicaron que los síntomas de duelo predecían una parte importante de la varianza en la toma de decisiones emocionales.CONCLUSIONES: la intensidad del duelo parece ir asociada a dificultades en la toma de decisiones emocionales

Assessment of different components of executive function in grief.

BACKGROUND: Intense and complex symptoms of grief seem to be related to a series of biases and difficulties in areas such as attention, autobiographical memory and problem solving. However, studies of neuropsychological performance have reported contradictory evidence. The role of executive function (EF) in bereaved individuals has not been systematically studied by differentiating between its components. METHOD: A total of 38 participants who had experienced the death of a loved one participated in this study. They were divided into two groups based on the intensity of their symptoms. They underwent neuropsychological assessments that included measures of flexibility, inhibition, working memory and emotional decision-making. RESULTS: Group differences were found in the parts of the emotional decision-making task that assessed decisions made under risk. Considering each participant’s level of education and emotional variables, the symptoms of grief predicted a substantial variance in their performance in the decision-making task. CONCLUSION: Intense symptoms of grief seem to be related to poorer emotional decision-making performance but not to flexibility, inhibition or working memory.

Assessment of Emotional Experience and Emotional Recognition in Complicated Grief.

There is substantial evidence of bias in the processing of emotion in people with complicated grief (CG). Previous studies have tended to assess the expression of emotion in CG, but other aspects of emotion (mainly emotion recognition, and the subjective aspects of emotion) have not been addressed, despite their importance for practicing clinicians. A quasi-experimental design with two matched groups (Complicated Grief, N = 24 and Non-Complicated Grief, N = 20) was carried out. The Facial Expression of Emotion Test (emotion recognition), a set of pictures from the International Affective Picture System (subjective experience of emotion) and the Symptom Checklist 90 Revised (psychopathology) were employed. The CG group showed lower scores on the dimension of valence for specific conditions on the IAPS, related to the subjective experience of emotion. In addition, they presented higher values of psychopathology. In contrast, statistically significant results were not found for the recognition of emotion. In conclusion, from a neuropsychological point of view, the subjective aspects of emotion and psychopathology seem central in explaining the experience of those with CG. These results are clinically significant for psychotherapists and psychoanalysts working in the field of grief and loss.

Adaptación al castellano de la Centrality of Event Scale (CES) / Adaptation of Centrality of Event Scale (CES) to Spanish

La "Centrality of Event Scale" (CES) es un instrumento utilizado para evaluar la centralidad que tiene una determinada experiencia en la persona. Estudios previos muestran que la centralidad es un constructo altamente relacionado con el estrés post-traumático, la depresión o el duelo complicado. El objetivo de este estudio fue realizar su adaptación al castellano y caracterizar su fiabilidad y validez. Participaron dos muestras compuestas por 208 y 320 estudiantes universitarios que completaron la CES y medidas de depresión (BDI), ansiedad (STAI) y sintomatologia de estrés post-traumático (PSS). Los resultados coinciden con los obtenidos con la versión original de la CES, tanto en consistencia interna (alfa de Cronbach de 0.92 y 0.94, para cada muestra), como en test-retest a los dos meses (r=0.803, p<0.01). El análisis de componentes principales muestra un único factor explicativo que daba cuenta del 45% de la varianza. Finalmente las puntuaciones de la CES muestran relaciones con diversos indices de psicopatologia, siendo además un predictor, junto con las medidas de ansiedad y depresión, del 32% de la sintomatologia de estrés post-traumático. La adaptación al castellano de la escala CES parece ser una medida válida y fiable sobre centralidad del evento.

The "Centrality of Event Scale" (CES) is an instrument used to assess the centrality that a particular event has in the person. Previous studies show that centrality is a construct highly relevant for post-traumatic stress symptomatho-logy, depression and complicated grief. The aim of this study was to adapt into Spanish the CES and obtain evidences of reliability and validity. Two samples consisting of208 and 320 college students participated in the study. They completed the CES and measures of depression (BDI), anxiety (STAI) and symptoms of post-traumatic stress (PSS). The results agree with those obtained by the original version of the CES, showing high internal consistency (Cronbach's alpha of 0.92 and 0.94, for each sample) and acceptable test-retest reliability at two months (r = 0.803, p < 0.01). The principal component analysis shows a single explanatory factor that accounted for 45% of the variance. Finally, CES scores show significative relationships with various indicators of psychopatholo-gy, and is also a predictor, along with measures of anxiety and depression, of the 32% of the symptoms of post-traumatic stress disorder. The Spanish version of the CES seems to be a valid and reliable measure of the centrality of the event.

Reliability and validity of the Arabic version of the computerized Battery for Neuropsychological Evaluation of Children (BENCI).

Batería de Evaluación Neuropsicológica Infantil (BENCI) is a computerized battery for the neuropsychological evaluation of children. This battery has been used in different studies to evaluate neuropsychological functions and neurodevelopment in children. The objective of this study is to test the validity and reliability of the first Arabic version of the BENCI on an Arabic population where neuropsychological tests are very scarce. We administrate the BENCI to 198 school-age children (98 boys and 100 girls) from Morocco. To examine the test retest reliability of the BENCI battery, we administered the battery 2 times to 43 children (23 boys and 20 girls) with 15 days in between the pre- and posttest. The results revealed good validity and reliability of the battery in Arabic children. Also, the BENCI battery has demonstrated the capacity to differentiate between children by their age group. This battery can be of great use to both the research and clinical areas of Arabic countries and/or in assistance to Arabic immigrants that live outside of their native country.

Cultural differences in neuropsychological abilities required to perform intelligence tasks.

Different studies have demonstrated that culture has a basic role in intelligence tests performance. Nevertheless, the specific neuropsychological abilities used by different cultures to perform an intelligence test have never been explored. In this study, we examine the differences between Spaniards and Moroccans in the neuropsychological abilities utilized to perform the Beta III as a non-verbal intelligence test. The results showed that the Spaniard group obtained a higher IQ than the Moroccan group in the Beta III. Moreover, the neuropsychological abilities that predicted scores for the Beta III were dependent on the country of origin and were different for each subtest. Besides showing the cultural effect on non-verbal intelligence test performance, our results suggest that a single test may measure different functions, depending on the subject's cultural background.

El resumen de los resultados en los artículos de investigación de Ciencias Comportamentales / Summary of results in research papers of behavioural sciences

El objetivo principal será la aplicación de desarrollos metodológicos recientes de cara a la adecuada elaboración del apartado de resultados propio de los artículos de investigación, atendiendo especialmente al campo de la Psicología y disciplinas comportamentales afines. Para ello, se exponen las generalidades sobre el resumen de información, resaltando especialmente la explicación detallada sobre la elección de la medida de error. En una segunda parte se presentan aspectos más específicos, discutiendo con detenimiento la adaptación de la medida de variabilidad error en función de dos parámetros básicos: el tipo de diseño de investigación y el grado de generalidad de la hipótesis de investigación. El trabajo se cierra con un ejemplo de aplicación de los conceptos expuestos con unos breves apuntes sobre la forma de agregar barras de error a los gráficos a partir de un programa de Hoja de Cálculo, como Microsoft Excel©

The main aim of this paper is the application of recent methodological developments in order to write adequately the results section of research papers, particularly in the field of Psychology and other behavioural sciences. Thus, we illustrate some general issues about how the in-formation should be summarized, emphasizing the need to explain in detail the choice of the error measure. The second part of the paper introduces more specific issues, as the adaptation of the error variability with reference to two parameters: the research design and the degree of generalization of the research hypothesis. This paper concludes with an applied example of the above issues, including some brief remarks about the way to add error bars to figures and graphics using a spread sheet program (i.e. Microsoft Excel©)