Análise das Políticas Públicas destinadas a deficientes auditivos: um estudo qualitativo / Analysis of public policies for the hearing impaired: a qualitative study

Objetivo: identificar as normatizações que efetivam as Políticas Públicas voltadas ao Deficiente Auditivo e analisar seus focos de atuação. Métodos: foi realizado um estudo qualitativo, descritivo e comparativo sobre as legislações relacionadas ao deficiente auditivo no Brasil, entre janeiro e junho de 2019, sendo todas de acesso público e disponíveis no portal do Planalto e do Ministério da Saúde. O período de identificação dessas legislações foi entre os anos 2000 e 2019. Dentro de cada base, a palavra-chave utilizada foi "deficiência auditiva" e a separação foi feita manualmente após a leitura da ementa de cada norma. Resultados: foram encontrados 11 arquivos diferentes, após a leitura exploratória dos documentos relacionados a legislações aplicáveis a deficientes auditivos, sendo três leis, um decreto e sete portarias. Conclusão: apesar de existir um número significativo de normas voltadas especificamente a esse assunto, a legislação vigente não alcança toda a população nacional na prática. Contudo, com a instituição das normas elencadas no presente estudo, é possível perceber a mobilização do Poder Público a fim de instituir Políticas Públicas, abrindo caminho para a efetivação de direitos dos Deficientes Auditivos.

Goal: identify the norms that effect the Public Policies aimed at the Hearing Impaired and analyze their focus of action. Methods: a qualitative, descriptive, and comparative study on legislation related to the hearing impaired in Brazil was conducted between January and June of 2019. All of them were publicly available on the Planalto and Ministry of Health databases. The identification period of these laws was between the years 2000 and 2019. In each base, the keywords used were "hearing impairment" (deficiência auditiva) and the separation was carried out manually after reading the proposal of each norm. Results: there were 11 different files after exploratory reading of the documents related to legislation applicable to the hearing impaired. These files included three laws, one decree and seven ordinances. Conclusion: although there is a significant number of norms specifically addressed to this subject, the current legislation does not reach the entire national population in practice. However, with the institution of the standards listed in the present study, it is possible to perceive the mobilization of the Public Power in order to institute Public Policies, allowing the realization of the Rights of the Hearing Impaired.

Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study.

Chronic venous ulcers affect the quality of life of patients around the world. The aims of this study were to identify the proteins expressed in chronic venous ulcer exudates, to categorize them according to their roles and to correlate them with the clinical and epidemiological aspects of the disease. The study population consisted of 37 ulcers from 28 patients, and the inflammatory exudates of these thirty-seven ulcers were subjected to tryptic digestion and mass spectrometry analysis. Twenty-three patients were female (62.2%), and five (37.8%) were male. The patients had a mean age of 70 (±10.1) years. Of the patients, 73% adhered to compression and rest, 81.1% reported a history of primary varices, 54.1% reported a history of systemic arterial hypertension, 54.1% reported a history of devitalized tissue in the wound bed and 64.9% reported ulcers with more than ten years of evolution. Seventy-six proteins were identified, and they were grouped according to their primary role in the healing process. Eight correlations between clinical and epidemiological data and protein expression were noteworthy: diabetes mellitus vs. Ig gamma-2 and apolipoprotein-A1 and albumin; congestive heart failure vs. Ig lambda-2; colonization vs. actin; compressive therapy vs. Ig kappa; systemic arterial hypertension vs. alpha-2-macroglobulin and apolipoprotein-A1; area of ulcer vs. apolipoprotein-A1; race vs. heavy chain Ig and Ig γ-1 chain; age and race vs. Ig γ-1 chain. These associations may help to elucidate the prognosis and chronicity of chronic venous ulcers based on secreted proteins.

Plasma proteome of buffaloes.

The proteomic approach has aroused the interest of veterinary medicine researchers, especially regarding the production of biopharmaceuticals and diagnosis of diseases in farm animals. Water buffaloes have gained prominence in the world economy due to the quality of their milk, meat, and leather, in addition to being an important donor of blood components. This work aimed to identify and characterize the proteins present in the blood plasma of Murrah buffaloes (Bubalus bubalis) through 2D electrophoresis, in gel protein digestion followed by mass spectrometry technique and for albumin depletion, in solution protein digestion followed by shotgun analysis. Our results showed the identification of 112 protein spots and 35 individual proteins, respectively. The abundant proteins were represented by albumin, fibrinogen-α, fibrinogen-ß, fibrinogen-γ, immunoglobulins in general, α-1-antiproteinase, α-1B-glycoprotein, α-2-HS-glycoprotein, α-macroglobulin, apolipoprotein A1, antithrombin-III, endopin 2B, fetuin-B, retinol-binding protein, serotransferrin, transthyretin and vitamin D-binding protein. Most of these proteins are related to the signaling pathways of the complement system and coagulation cascade. The results allowed a better understanding of the protein composition of these blood components, thus promoting studies on animal health in the search for molecular markers of zoonotic diseases in buffaloes.