Desarrollo del programa de atención específica al trastorno psicótico incipiente en Benito Menni Casm / No disponible

La atención a las personas que han desarrollado o pueden llegar a desarrollar una psicosis incipiente debe realizarse de forma precoz. Por ello, la detección es el paso fundamental, seguida del diagnóstico, tratamiento y recuperación de la persona. Todas estas intervenciones transversales son realizadas por diferentes profesionales sanitarios y no sanitarios ubicados en dispositivos diferentes y de entidades proveedoras dispares, lo cual requiere la creación de alianzas y trabajo en red bajo el paraguas de una Unidad Funcional que permita situar a la persona en el centro para que pueda recibir la atención más necesaria en cada momento siguiendo su proyecto vital. Dicha Unidad Funcional debe ser territorial, transversal y comunitaria. En este artículo mostramos el proceso que se ha seguido en la creación de las unidades funcionales del Programa de Atención Específica al Trastorno Psicótico Incipiente (PAE- TPI), así como las comisiones de seguimiento y los resultados preliminares para cada uno de los sectores de referencia de Benito Menni CASM (L'Hospitalet, Sant Boi y Vallès Oriental)

Attention to people who have developed or may develop an incipient psychosis should be done early. Therefore, detection is the fundamental step, followed by diagnosis, treatment and recovery of the person. All these cross-cutting interventions are carried out by different health and non-health professionals, who work in different services and from different providers. The creation of a Functional Unit have two main aims: to reach a professional networking as well as to offer a personalized intervention and a long term monitoring to the target patients of the program. This Functional Unit must be territorial, transversal and community based. In this article we show the process that has been followed in order to create the functional units and the monitoring work commissions of the "Program of Specific Attention to the Incipient Psychotic Disorder", as well as inform about the preliminary results of the three reference population areas assisted by Benito Menni CASM (L'Hospitalet, Sant Boi and Vallès Oriental)

Low baseline serotonin-2A receptors predict clinical response to olanzapine in first-episode schizophrenia patients.

The purpose of this study was to determine whether platelet serotonin-2A (5-HT2A) binding sites and inositol 1,4,5 trisphosphate (IP3) concentrations before treatment can identify olanzapine-responsive patients. The study included 21 never medicated, first-episode schizophrenia patients (antipsychotic-naïve) and 21 patients with a DSM-IV-TR diagnosis of paranoid schizophrenia who had not received depot antipsychotic treatment in the previous 6 months or oral antipsychotic or antidepressant treatment in the previous 2 months (antipsychotic-free). In the antipsychotic-naïve group, olanzapine responders had a significantly lower number of 5-HT2A receptors and lower IP3 concentrations at baseline than non-responders. The combination of baseline 5-HT2A and IP3 values significantly predicted an improvement in negative symptomatology after 6 weeks of treatment with olanzapine. In the antipsychotic-free group, responders had significantly higher positive and lower negative symptomatology at baseline, together with a reduced number of 5-HT2A receptors. However, basal 5-HT2A receptors or IP3 concentrations did not significantly predict positive, negative or general clinical response. The reported results suggest that platelet 5-HT2A binding might be a trait marker that could help to identify those patients likely to show greater improvement in negative symptomatology after olanzapine treatment.