RESUMO
Dietary supplements (DS) pose many side effects and multiple interactions with perioperative medications, which may increase surgical morbidity and mortality. Descriptive empirical data are essentially nonexistent related to DS consumption and patient knowledge of DS. The aims of this study were to investigate the prevalence of use, type of supplements used, and the knowledge base among military beneficiaries and veterans consuming DS during the preoperative period. This descriptive cross-sectional study solicited data from 2,623 volunteer, preoperative patients at 6 different military medical centers throughout the United States. Of the 2,623 participants, 847 (32.3%) reported taking at least 1 DS. Relevant to the surgical population, 154 (18.1%) of participants reported consuming DS that are associated with an increased risk of bleeding. Importantly, we found that 89.7% of patients taking DS were not aware of any potential side effects, and 97.1% lacked knowledge regarding any potential medication interactions between the supplement consumed and their prescribed medications. This vast knowledge gap could have deleterious effects on surgical outcomes. An increase in DS research is needed, and patient education should be incorporated routinely during preoperative assessments provided by military and Veterans Affairs healthcare facilities.
Assuntos
Suplementos Nutricionais , Família , Conhecimentos, Atitudes e Prática em Saúde , Veteranos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Enfermeiros Anestesistas , Período Perioperatório , Inquéritos e Questionários , Estados Unidos , Adulto JovemRESUMO
Anxiety and depression are debilitating, costly psychological disorders that account for more than $133 billion annually in direct medical expenses in the United States. Finding alternative treatments to reduce the personal and financial burden for patients with these disorders, while maintaining patient safety, is vital. The purposes of this study were to determine if crocin, a compound from saffron (Crocus sativus L), produces anxiolytic and/or antidepressant effects using rat models for anxiety and behavioral despair and to determine the effects of crocin at the benzodiazepine site on the γ-aminobutyric acid type A receptor. Fifty-five male Sprague Dawley rats were randomly assigned to 1 of 5 groups: vehicle (dimethyl sulfoxide), crocin, midazolam, flumazenil plus crocin, and midazolam plus crocin. Behavioral analyses were conducted in the elevated plus-maze and the forced swim test. Data were analyzed using multivariate analysis of variance and a least significant difference post hoc test. Data from the elevated plus-maze suggested crocin may attenuate the anxiolytic effects of midazolam, while not affecting psychomotor activity. Data from the forced swim test showed a significant increase in mean time mobile in the midazolam plus crocin group, suggesting a decrease in behavioral despair because of the interaction between crocin and midazolam.
Assuntos
Antidepressivos/uso terapêutico , Crocus , Transtorno Depressivo/tratamento farmacológico , Modelos Animais de Doenças , Extratos Vegetais/uso terapêutico , Animais , Antidepressivos/administração & dosagem , Antidepressivos/farmacologia , Masculino , Extratos Vegetais/administração & dosagem , Extratos Vegetais/farmacologia , Ratos , Ratos Sprague-Dawley , Comportamento Estereotipado/efeitos dos fármacosRESUMO
Anxiety and depression are debilitating, costly psychological disorders that account for $133 billion in direct medical expenses per year in the United States. Finding alternative means of treatment to reduce the personal and financial burden for patients with these disorders, while maintaining patient safety, is vital for overall patient wellness. The purposes of this study were 2-fold: (1) to determine if pure eucalyptol (1,8-cineole) produces anxiolytic and/or antidepressant effects using rat models for anxiety and behavioral despair and (2) to determine the effects of eucalyptol at the benzodiazepine site on the γ-aminobutyric acid (GABA) A receptor in the rat central nervous system. Fifty-five male Sprague-Dawley rats were randomly assigned to 1 of 5 groups: vehicle (dimethyl sulfoxide), eucalyptol, midazolam, flumazenil plus eucalyptol, and midazolam plus eucalyptol. Behavioral analyses were conducted on the elevated plus-maze and in the forced swim test. Data were analyzed using a 2-tailed multivariate analysis of variance and a least significant difference post hoc test. Data from the maze suggested eucalyptol may produce anxiolytic effects by acting at the benzodiazepine site on the GABAA receptor while not affecting psychomotor activity. However, no effects on behavioral despair were demonstrated in the Forced Swim test.