RESUMO
AIM: To assess the frequency distribution of six Y-chromosomal specific short tandem repeat (STR) polymorphisms and frequencies of haplotypes in Turkish population. METHODS: Blood samples were taken from 200 unrelated Turkish men from different regions of Turkey, who were involved in legal proceedings concerning paternity. The DNA was amplified and typed by use of Y-Plex 6 kit containing 6 Y-STR markers (DYS393, DYS19, DYS389 II, DYS390, DYS391, and DYS385). Capillary electrophoresis was carried out on an ABI 310 Genetic Analyzer. RESULTS: Allele frequency profiles of the Turkish men showed no significant differences compared with previously published results for Swiss and German populations. The range of gene diversity was determined between 48.3% for DYS391 and 96.0% for DYS385. Of 184 determined haplotypes, 170 occurred once, and the rest more than once. The most common haplotypes had a frequency of 1.5%. CONCLUSION: High degree of haplotype diversity in Turkish population makes analysis of Y-STRs a useful tool in forensic cases.
Assuntos
Cromossomos Humanos Y/genética , Frequência do Gene , Haplótipos , Sequências de Repetição em Tandem , Medicina Legal , Humanos , Masculino , Paternidade , Polimorfismo Genético , TurquiaRESUMO
Allele and genotype frequencies for the nine loci, HumCSF1PO, HumTHO1, HumTPOX, HumFES/FPS, HumF13B, HumVWA, D3S1358, D7S820 and D16S539 were determined using Silver STR III System on 223-598 unrelated Turkish individuals from different regions of the country.
Assuntos
Genética Populacional , Sequências de Repetição em Tandem/genética , Frequência do Gene , Genótipo , Humanos , TurquiaRESUMO
Allele and genotype frequencies for the nine loci D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317 and D7S820 were determined for 310 unrelated Turkish individuals.