Percutaneous Vertebroplasty Versus Conservative Treatment and Rehabilitation in Women with Vertebral Fractures due to Osteoporosis: A Prospective Comparative Study.

BACKGROUND: Percutaneous vertebroplasty is commonly used in the management of osteoporosis-related vertebral fractures, although there is controversy on its superiority over conservative treatment. Here we compare pain and function in women with vertebral osteoporotic fractures who underwent percutaneous vertebroplasty versus conservative treatment with a protocolized rehabilitation program. METHODS: A longitudinal and comparative prospective study was conducted. Women ≥ 60 years of age with a diagnosis of osteoporosis who had at least one vertebral thoracic or lumbar compression fracture were included and divided into two groups, conservative treatment or vertebroplasty. The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were used to assess pain and function, respectively, as the outcome measures. RESULTS: We included 31 patients, 13 (42%) treated with percutaneous vertebroplasty and 18 (58%) with conservative treatment. Baseline clinical characteristics, bone densitometry and fracture data were similar in both groups. At baseline, VAS was 73.1 ± 28.36 in the vertebroplasty group and 68.6 ± 36.1 mm in the conservative treatment group (p = 0.632); at three months it was 33.11 ± 10.1 vs. 42 ± 22.21 mm (p = 0.111); and at 12 months, 32.3 ± 11.21 vs. 36.1 ± 12.36 mm (p = 0.821). The ODI at baseline was 83% in the vertebroplasty group vs. 85% for conservative management (p = 0.34); at three months, 36 vs. 39% (p = 0.36); and at 12 months, 29.38 vs. 28.33% (p = 0.66). CONCLUSIONS: Treatment with percutaneous vertebroplasty had no advantages over conservative treatment for pain and function in this group of women ≥ 60 years of age with osteoporosis.

Renal function status in patients with primary osteoporosis (type 2).

BACKGROUND: Several studies correlate renal function with lower bone mineral density (BMD); however, the relationship between early stages of renal dysfunction and BMD has not been clearly defined. Our objective was to determine renal function in patients with primary osteoporosis (type 2) and its relationship with BMD. METHODS: Patients with primary osteoporosis diagnosed using DEXA were evaluated in this cross-sectional analysis. Renal function was estimated according to the modification of diet in renal disease (MDRD) equation and classified according to the National Kidney Foundation for chronic kidney disease (CKD). The relationship between renal function and BMD was analyzed. RESULTS: Included in the study were 120 women with a mean age 67.9 + or - 6.56 years. There was a positive relationship between spine BMD and moderate affection of renal function (F = 4.860, p = 0.009). No relationship was found between hip BMD or fracture with renal function (p = 0.223). CONCLUSIONS: Although women with poor renal function have significantly lower spine BMD, no relationship between early stages of CKD and low BMD has been demonstrated.

Estado del funcionamiento renal de pacientes con osteoporosis primaria (tipo 2) / Renal function status in patients with primary osteoporosis (type 2)

Introducción: Diversos estudios han corroborado la relación entre la insuficiencia renal crónica y la disminución de la densidad mineral ósea; sin embargo, no se ha determinado la misma en presencia de función renal levemente disminuida. El objetivo de esta investigación fue valuar el estado de la función renal en pacientes con osteoporosis primaria y su relación con la densidad mineral ósea. Material y métodos: Estudio prospectivo, transversal, descriptivo, en pacientes con osteoporosis primaria determinada mediante densitometría central (cadera y columna). Se calculó la función renal con la fórmula MRDR (modification of diet in renal disease) en base a la creatinina sérica. Los resultados se clasificaron utilizando las categorías recomendadas por The National Kidney Foundation. Se analizó la relación entre el grado de alteración del funcionamiento renal y la densidad mineral ósea. Resultados: 120 mujeres con edad promedio de 67.9 ± 6.56 años. Se encontró correlación entre valores menores de densidad mineral ósea de columna (T score) y afección moderada de la función renal (F = 4.860, p = 0.009). No hubo relación entre la densitometría de cadera con la función renal ni entre la función renal y el antecedente de fractura (p = 0.223). Conclusiones: Existe relación significativa entre la disminución de la densidad mineral ósea de columna y el deterioro de la función renal de las pacientes con osteoporosis primaria. No fue significativa la relación de la función renal con la incidencia de fracturas en esta población.

BACKGROUND: Several studies correlate renal function with lower bone mineral density (BMD); however, the relationship between early stages of renal dysfunction and BMD has not been clearly defined. Our objective was to determine renal function in patients with primary osteoporosis (type 2) and its relationship with BMD. METHODS: Patients with primary osteoporosis diagnosed using DEXA were evaluated in this cross-sectional analysis. Renal function was estimated according to the modification of diet in renal disease (MDRD) equation and classified according to the National Kidney Foundation for chronic kidney disease (CKD). The relationship between renal function and BMD was analyzed. RESULTS: Included in the study were 120 women with a mean age 67.9 + or - 6.56 years. There was a positive relationship between spine BMD and moderate affection of renal function (F = 4.860, p = 0.009). No relationship was found between hip BMD or fracture with renal function (p = 0.223). CONCLUSIONS: Although women with poor renal function have significantly lower spine BMD, no relationship between early stages of CKD and low BMD has been demonstrated.