RESUMO
PURPOSE: Evaluation of a new treatment for keloid scars using a 40% phenol solution in accordance with a predefined protocol. PATIENTS AND METHODS: A retrospective study was made of the files of 25 patients treated with phenol from June 2010 to March 2012. RESULTS: The keloids were located predominantly on the trunk (48%) and upper extremities (34%). The total number of keloids was 52, with a median size of 11.16 cm(2). Phenol was the sole and first-line treatment in 40% of cases. Patient adherence to the protocol of phenol was noted in 81% of cases. The mean number of phenol sessions was 14.2. Seventy-two percent of patients were satisfied with the treatment. Mean regression in keloid size of 75.5% was noted. A change in local keloid pigmentation was observed in 75% of patients. Local adverse reactions (itching, infection, ulceration) were seen in 6 patients (28.6%). No cases of systemic signs of phenol were observed. After mean follow-up of 12.8 months, no recurrence of keloids was noted. CONCLUSION: Use of phenols in the topical treatment of keloids appears valuable since it is easy to apply and provides good results with few side effects.
Assuntos
Queloide/terapia , Fenol/uso terapêutico , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estudos Retrospectivos , Adulto JovemAssuntos
Lentigo/diagnóstico , Neurofibromatoses/diagnóstico , Abdome/patologia , Criança , Diagnóstico Diferencial , Face/patologia , Feminino , Humanos , Lentigo/classificação , Lentigo/complicações , Lentigo/genética , Neurofibromatoses/classificação , Neurofibromatoses/complicações , Neurofibromatoses/genética , Linhagem , Índice de Gravidade de Doença , Pele/patologia , Tórax/patologiaRESUMO
BACKGROUND: Juvenile xanthogranuloma (JXG) is a form of self-healing non-Langerhans histiocytosis. We report a new case of disseminated JXG without visceral involvement but with positive immunostaining of the majority of histiocytes for protein S100. PATIENTS AND METHODS: A 6-month-old male infant was admitted to our department in January 2010 for congenital nodular lesions of varying size, shape and appearance. The remainder of the dermatological and physical examination was unremarkable. The diagnosis of disseminated JXG, strongly suggested clinically, was confirmed by a skin biopsy. However, immunohistochemistry was confusing, with positivity for protein S100. The lesions regressed spontaneously. DISCUSSION: The aim of this case report is to highlight the lack of any forced association between alarming skin lesions of eruptive JXG and systemic involvement. The distinguishing feature of our case is the positive immunostaining for protein S100 in the histological section, which although rare in XJG, does not cast doubt on the diagnosis of non-Langerhans histiocytosis providing the clinical presentation is typical. Therapeutic abstention is the rule.
Assuntos
Proteínas S100/biossíntese , Xantogranuloma Juvenil/metabolismo , Humanos , Lactente , Masculino , Xantogranuloma Juvenil/patologiaAssuntos
Lúpus Vulgar/patologia , Antituberculosos/uso terapêutico , Braço , Doença Crônica , Diagnóstico Tardio , Diagnóstico Diferencial , Etambutol/administração & dosagem , Etambutol/uso terapêutico , Feminino , Hemangioma Capilar/diagnóstico , Humanos , Isoniazida/administração & dosagem , Isoniazida/uso terapêutico , Lúpus Vulgar/diagnóstico , Lúpus Vulgar/tratamento farmacológico , Pessoa de Meia-Idade , Síndromes Neoplásicas Hereditárias/diagnóstico , Rifampina/administração & dosagem , Rifampina/uso terapêuticoRESUMO
The incidence of cutaneous leishmaniasis has shown a resurgence in recent years in Tunisia. Because of the toxicity and high cost of pentavalent antimonials we have sought alternative medications. In a study of 14 patients with cutaneous leishmaniasis, ten patients achieved complete clinical regression of the lesions with oral administration of doxycycline, 200mg per day, for 15-30 days.
