RESUMO
Histological and electron microscopic changes in the hepatic structure were studied in animals with acute experimental cholecystitis. The administration of the succinate-containing drugs reamberin and mexidole decreased the magnitude of morphological changes in the liver tissue. Morphometric examination revealed that reamberin versus mexidole showed a high efficacy in reducing the area of hepatocytic necrosis.
Assuntos
Colecistite Aguda/patologia , Hepatócitos , Fígado , Meglumina/análogos & derivados , Succinatos/administração & dosagem , Ácido Succínico/administração & dosagem , Animais , Colecistite Aguda/tratamento farmacológico , Modelos Animais de Doenças , Feminino , Cobaias , Hepatócitos/efeitos dos fármacos , Hepatócitos/patologia , Hepatócitos/ultraestrutura , Fígado/efeitos dos fármacos , Fígado/patologia , Fígado/ultraestrutura , Masculino , Meglumina/administração & dosagem , Necrose/tratamento farmacológico , Necrose/patologiaRESUMO
Experiments were conducted in vitro; a study was mode of the age peculiarities attending be invluence of adrenaline, ACTH, STH on the lypolysis in the adipose tissue of rats under normal conditions and in starvation. During the process of ageing there occurs no change in the adipose tissue sensitivity to the action of hormones stimulating the lipolysis, but the capacity to react to high hormone doses is decreased. Elevation of the basal lypolysis in the adipose tissue of young rats occurs during starvation; the lypolytic action of the hormones falls. Starvation fails to alter the basal lypolysis in the adipose tissue to react to the hormone action.
