RESUMO
PURPOSE: To evaluate the prevalence of dry eye symptoms after endoscopic dacryocystorhinostomy (EDCR) for patients with primary acquired nasolacrimal duct obstruction (PANDO) combined with dry eye syndrome. METHODS: The patients diagnosed with PANDO combined with dry eye syndrome who underwent EDCR were divided into two groups according to the questionnaire about dry eye symptoms after surgery. The medical records were retrospectively analyzed. Before and after surgery, we compared the tear meniscus height, tear breakup time, and the presence of corneal punctuate epithelial erosion. The level of dry eyes of patients after surgery was assessed by using the Korean guidelines for the diagnosis of dry eye. RESULTS: At 6 months after EDCR, the proportion of patients with dry eye symptoms was 30% in a total of 80 patients. The duration of epiphora and tear breakup time after EDCR were higher in the group without dry eye symptoms and the proportion of eyes with corneal punctuate epithelial erosion after EDCR was higher in the group with dry eye symptoms. About 15% of total patients started treatment with a dry eye of level 2 or higher. CONCLUSIONS: About 15% of patients who underwent EDCR for PANDO combined with dry eye syndrome developed significant dry eye syndrome after surgery. The short onset of epiphora was associated with the development of the dry eye symptoms. Therefore, it is necessary to evaluate dry eye syndrome before surgery, and surgeons should be careful about this.
Assuntos
Dacriocistorinostomia , Síndromes do Olho Seco , Lacerações , Obstrução dos Ductos Lacrimais , Ducto Nasolacrimal , Humanos , Obstrução dos Ductos Lacrimais/diagnóstico , Estudos Retrospectivos , Ducto Nasolacrimal/cirurgia , Síndromes do Olho Seco/diagnóstico , Síndromes do Olho Seco/cirurgia , Lacerações/cirurgiaRESUMO
The purpose of this study was to investigate the effects of intraoperative fibrin glue use on surgery for blepharoptosis. This retrospective study included patients with acquired blepharoptosis who underwent surgical correction and were followed for at least one month. Patients were classified into two groups depending on whether treated with antithrombotic agents or otherwise. All patients taking antithrombotic agents discontinued with the treatment one week prior to surgery in accordance with our clinical guidelines. Preoperative and postoperative marginal reflex distance 1(MRD1) and ecchymosis grade were evaluated and compared. The subjects were 56 patients (111 eyes) who discontinued antithrombotic agents before surgery and 59 patients (117 eyes) who had never taken antithrombotic agents. Fibrin glue was used in 13 patients (26 eyes, 23.4%) in the antithrombotic group, and 11 patients (21 eyes, 17.9%) in the non-antithrombotic group. The rate of severe ecchymosis was significantly lower in patients who used fibrin glue in the antithrombotic group at 1 week (11.5 vs 40.0%, p = 0.008). However, in non-antithrombotic group, there was no difference in the rate of severe ecchymosis according to the use of fibrin glue at 1 week (14.3 vs 30.2%, p = 0.181). In patients with a history of taking antithrombotic agents, the intraoperative use of fibrin glue is thought to be helpful as it could significantly reduce significant ecchymosis.
Assuntos
Blefaroplastia , Blefaroptose , Adesivos Teciduais , Humanos , Adesivo Tecidual de Fibrina/uso terapêutico , Blefaroplastia/efeitos adversos , Blefaroptose/cirurgia , Estudos Retrospectivos , Fibrinolíticos/uso terapêutico , Equimose/tratamento farmacológico , Equimose/cirurgia , Complicações Pós-Operatórias/tratamento farmacológico , Resultado do TratamentoRESUMO
PURPOSE: To determine factors influencing postoperative enophthalmos after reconstruction of orbital wall fracture. METHOD: Data of consecutive patients who were diagnosed with unilateral medial or inferior orbital wall fracture from March 2013 to February 2020 were retrospectively reviewed. Forty-three patients were included in this study (24 with medial orbital wall fracture and 19 with inferior orbital wall fracture). Their medical records including Hertel exophthalmometry, preoperative computed tomography (CT) scan, and postoperative CT scan were reviewed. The degree of enophthalmos developed was calculated by measuring exophthalmos before surgery and at 6âmonths after surgery. Patients were classified into 2 groups depending on whether reduction was good after surgery or not. Data (eg, age, gender, onset, fracture size, and so on) were then compared between these 2 groups. RESULTS: A total of 43 patients were included in the study. Their mean age was 40.1âyears. There were 34 (79.1%) males. The mean onset from trauma to surgery was 8.1âdays. Insufficient soft tissue reduction was found in 9 patients through postoperative CT scan. Preoperative mean enophthalmos was - 1.70âmm. Postoperative mean enophthalmos was -0.45âmm after 6âmonths. The mean fracture size was 213.74 mm2. There was no statistically significant difference in enophthalmos at 6âmonths after surgery regardless whether the reduction was good or not. Enophthalmos at 6âmonths after surgery was associated with preoperative fracture size and onset. CONCLUSIONS: Postoperative enophthalmos development might be associated with preoperative fracture size and onset. Delayed operation in case of large orbital wall fracture might lead to undesired result. Thus, surgeons should keep that in mind.
Assuntos
Enoftalmia , Fraturas Orbitárias , Procedimentos de Cirurgia Plástica , Adulto , Enoftalmia/complicações , Enoftalmia/cirurgia , Feminino , Humanos , Masculino , Órbita/cirurgia , Fraturas Orbitárias/complicações , Fraturas Orbitárias/diagnóstico por imagem , Fraturas Orbitárias/cirurgia , Procedimentos de Cirurgia Plástica/efeitos adversos , Procedimentos de Cirurgia Plástica/métodos , Estudos RetrospectivosRESUMO
PURPOSE: To evaluate the effects of discontinuing anticoagulants (ACs)/antiplatelets (APs) preoperatively on surgery for blepharoptosis. METHOD: A retrospective analysis included patients with acquired blepharoptosis who underwent surgical correction, and were followed for more than 1 month. Patients were classified into 2 groups depending on AC/AP treatment or otherwise. All patients taking AC/AP discontinued with the treatment 1 week prior to surgery in accordance with our clinical guidelines. Preoperative and postoperative marginal reflex distance 1 (MRD1) and ecchymosis grade were evaluated and compared. RESULTS: Group 1 (AC/AP treatment cessation) included 47 patients with 93 eyelids, and group 2 (control) included 51 patients with 98 eyelids. The preoperative MRD1 showed no significant difference between groups. Group 1 showed a significantly higher rate of severe ecchymosis (41.8 versus 22.4%, P = 0.004) at 1 week of surgery as well as persistent ecchymosis (58.8 versus 7.3%, P = 0.000) compared with group 2 postoperatively at 1 month. Postoperative MRD1 was significantly lower in group 1 at 1 week (P = 0.019). However, the MRD1 and degree of improvement in lid height (postoperative MRD1 "preoperative MRD1) was not significantly different between the 2 groups (P = 0.499, P = 0.058) at 1 month postoperatively. CONCLUSIONS: Postoperative ecchymosis was more severe in group 1 at 1 month after ptosis surgery even though the ACs/APs were discontinued. Surgeons should be careful about this before operation. THE SYNOPSIS: Significant ecchymosis could occur even after discontinuation of antithrombotic agents in patients with a history of taking medication in ptosis surgery. Surgeons should be careful about this before operation.
Assuntos
Blefaroplastia , Blefaroptose , Anticoagulantes/efeitos adversos , Blefaroptose/induzido quimicamente , Blefaroptose/cirurgia , Equimose , Hemorragia/cirurgia , Humanos , Músculos Oculomotores/cirurgia , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: To compare outcomes of Mueller's Muscle Conjunctival Resection (MMCR) between 2 groups of patients with different anatomy due to ethnic heritage. METHODS: The medical records of patients who underwent MMCR between 2013 and 2018 were retrospectively reviewed. Patients who underwent additional procedures, such as upper blepharoplasty and browplasty, were excluded from the study. Patients were divided in 2 groups based on self-identified ethnic groups (Asian and Caucasian). Image J software was used to calculate MRD1 from digital images. The improvement of MRD1 (net MRD1) after surgery was evaluated and compared between 2 groups. RESULTS: Eighty-three eyes of 68 patients were included in this study. The Asian group consisted of 41 eyelids from 28 patients. The Caucasian group consisted of 42 eyelids from 40 patients. The average age was 52.18 (SD 20.176) in the Asian group compared with the 66.45 years (SD 9.22, p < 0.005) in the Caucasian group. The mean improvement of MRD1 was 1.96 ± 0.75 mm in Asian group and 2.05 ± 0.72 mm in Caucasian group, which was not statistically significant (p = 0.62). The incidence of ptosis overcorrection and undercorrection between the groups was also not statistically significant. CONCLUSIONS: There was no statistically significant difference in the surgical outcomes among the 2 study groups. Despite differences in the anatomy of Caucasian and Asian eyelids, MMCR is a successful procedure in patients self-identified from both ethnic groups.
Assuntos
Blefaroplastia , Blefaroptose , Blefaroptose/cirurgia , Etnicidade , Pálpebras/cirurgia , Humanos , Pessoa de Meia-Idade , Músculos Oculomotores/cirurgia , Estudos Retrospectivos , SuturasRESUMO
PURPOSE: To evaluate the effectiveness of preoperative lacrimal endoscopic evaluation (LEE) of lacrimal duct system (LDS). DESIGN: Retrospective comparative case series METHODS: From March 2016 to February 2020, the charts of patients chosen to undergo endoscopic dacryocystorhinostomy (EDCR) or silicone tube intubation (STI) were reviewed retrospectively. Group 1 included patients that underwent EDCR, and group 2 included patients that underwent STI. Preoperative LEE was performed for all patients. In group 1, we compared the functional success rate for patients who had been converted to STI with the patients who had undergone EDCR. In group 2, we compared the functional success rate of STI with those who had had STI without LEE. RESULTS: In group 1, 19 (54.3%) eyes were converted to STI following LEE, and the functional success rate was 84.2%, which is not significantly different from that of the EDCR group following LEE (p = 0.608). The functional success rate of EDCR without LEE was not different from that of STI following LEE (p = 1.000). In group 2, five eyes (26.3%) were converted to EDCR following LEE. The group undergoing STI following LEE showed a significantly higher functional success rate (95.7%) than the group without LEE (66.6%, p = 0.023). CONCLUSION: Preoperative LEE enables direct visualization of the LDS and helps to obtain more accurate diagnosis. This allows for the best surgical option based on LEE findings, which can contribute to better results. Therefore, LEE would be expected to change the paradigm of the classical management of LDS.
Assuntos
Dacriocistorinostomia , Aparelho Lacrimal , Obstrução dos Ductos Lacrimais , Ducto Nasolacrimal , Endoscopia , Pálpebras , Humanos , Aparelho Lacrimal/diagnóstico por imagem , Aparelho Lacrimal/cirurgia , Obstrução dos Ductos Lacrimais/diagnóstico , Obstrução dos Ductos Lacrimais/terapia , Ducto Nasolacrimal/diagnóstico por imagem , Ducto Nasolacrimal/cirurgia , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: To report adverse hemorrhagic outcomes in patients who received intravenous (IV) ketorolac during oculofacial plastic surgical procedures. METHODS: The medical records of 111 consecutive patients who underwent lacrimal or orbital surgery, between the years 2016 and 2018, performed by a single surgeon under general anesthesia were retrospectively reviewed. Patients were excluded if they had history of a bleeding coagulopathy, anticoagulant use prior to surgery, or insufficient follow up. Patients were divided into 2 groups based on whether they received intravenous ketorolac. The primary outcome measure was the occurrence of a major postoperative bleeding event, and the secondary outcome measures were the evaluation of postoperative ecchymosis graded at 1 week after surgery and the incidence of persistent ecchymosis beyond 4 weeks. RESULTS: A total of 111 patients were analyzed further, including 31 patients who received intraoperative IV ketorolac and 80 control patients who did not. The demographic characteristics between the 2 groups were similar. No major bleeding events occurred in either group. And there was no statistically significant difference between the 2 groups in terms of ecchymosis grade and the incidence of development of persistent ecchymosis. Comparing the subgroups of lacrimal and orbital cases, there was also no significance difference between these groups. CONCLUSIONS: This study suggests that intraoperative ketorolac use does not increase the risk of postoperative bleeding complications in oculofacial procedures. This alternative to opioids may assist with pain control and lessen the narcotic burden.
Assuntos
Cetorolaco , Dor Pós-Operatória , Analgésicos Opioides , Anti-Inflamatórios não Esteroides/efeitos adversos , Humanos , Cetorolaco/efeitos adversos , Dor Pós-Operatória/tratamento farmacológico , Hemorragia Pós-Operatória/induzido quimicamente , Hemorragia Pós-Operatória/epidemiologia , Estudos RetrospectivosRESUMO
PURPOSE: To evaluate the clinical usefulness of the dacryoscintigraphy in patients with nasolacrimal duct obstruction prior to endoscopic dacryocystorhinostomy. METHODS: One hundred thirty-five lacrimal views of endoscopic dacryocystorhinostomy (DCR) with a single surgeon for primary nasolacrimal duct obstruction (PANDO) were included. These were assigned into three groups according to the type of dacryoscintigraphy. Group 1 was a pre-sac obstruction pattern. Group 2 was an intra-sac obstruction pattern. Group 3 was post-sac obstruction pattern. Each group was evaluated for an anatomical and functional surgical success, presence of complications including granuloma, synechiae, and tube-induced inflammation at least 12 months after the surgery. RESULTS: Both anatomical and functional success rate showed no significant difference among the three groups (P = .297 and .472 linear by linear association). Functional failure rate (functional failure/total failure) also showed no clinically significant differences between groups. Logistic regression analysis was performed to determine the factors associated with functional success. There were no statistically significant factors in age, sex, scintigraphy type, pre-operative endoscopic grade, post-operative granuloma, and synechiae. CONCLUSION: In patients with nasolacrimal duct obstruction, preoperative evaluation of obstruction level using dacryoscintigraphy may be not useful for predicting the functional success of the endoscopic dacryocystorhinostomy.
Assuntos
Dacriocistorinostomia/métodos , Endoscopia/métodos , Aparelho Lacrimal/diagnóstico por imagem , Obstrução dos Ductos Lacrimais/diagnóstico , Ducto Nasolacrimal/diagnóstico por imagem , Cuidados Pré-Operatórios/métodos , Cintilografia/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Aparelho Lacrimal/cirurgia , Masculino , Pessoa de Meia-Idade , Ducto Nasolacrimal/cirurgia , Prognóstico , Reprodutibilidade dos Testes , Estudos Retrospectivos , Índice de Gravidade de DoençaRESUMO
Purpose: Acanthamoeba keratitis is a well-known intractable corneal infectious disease. We investigated the anti-Acanthamoeba effect of exogenous nitric oxide (NO). Methods: Acanthamoeba castellanii was axenically cultured and exposed to various concentrations of NO donors, such as sodium nitrite, sodium nitroprusside (SNP), and NO-releasing silica nanoparticles (coated in branched polyethylene imine, size:100 nm), for 1 to 7 days (sodium nitrite and SNP: 0, 0.1, 1, 10, 100, and 1000 µM; silica nanoparticles: 0, 6.25, 12.5, 25, 50, and 100 µg/mL). Human corneal epithelial cells (HCECs) were cultured and exposed to sodium nitrite, SNP (0, 0.1, 1, 10, 100, and 1000 µM), and silica nanoparticles for 1, 2, and 3 days. Results: Sodium nitrite and SNP showed a dose-dependent inhibitory effect on A. castellanii viability. A more prominent inhibitory effect was observed with SNP (less than 10% of organisms survived at 7-day culture with 1000 µM) compared with sodium nitrite. However, more cytotoxicity on HCEC was observed with SNP. NO-releasing silica nanoparticles were successfully internalized into the amoebic cytoplasm and accumulated in large vacuoles. Although blank silica nanoparticles had no inhibitory effect on A. castellanii viability, NO-releasing silica nanoparticles showed a dose-dependent amoebicidal effect. Furthermore, no cystic transformation of A. castellanii was observed under a phase contrast microscope or transmission electron microscope after exogenous NO treatment. Conclusions: Our results demonstrated the anti-Acanthamoeba effect of exogenous NO. This finding suggests that NO-releasing drug platforms, including nano-carriers, can be a promising therapeutic strategy for Acanthamoeba keratitis.
Assuntos
Acanthamoeba castellanii/efeitos dos fármacos , Antiprotozoários/farmacologia , Sequestradores de Radicais Livres/farmacologia , Óxido Nítrico/farmacologia , Acanthamoeba castellanii/ultraestrutura , Animais , Sobrevivência Celular , Células Cultivadas , Relação Dose-Resposta a Droga , Epitélio Corneano/efeitos dos fármacos , Epitélio Corneano/ultraestrutura , Humanos , Microscopia Eletrônica de Transmissão , Microscopia de Contraste de Fase , Doadores de Óxido Nítrico/farmacologiaRESUMO
BACKGROUND: To investigate characteristics of biofilm which is usually found in silicone tube for nasolacrimal duct surgery and can be the root of chronic bacterial infections eventually resulted in surgical failure. METHODS: To form a biofilm, sterile silicone tube was placed in culture media of Staphylococcus aureus, Corynebacterium matruchotii, Pseudomonas aeruginosa, or Streptococcus pneumonia. Biofilms formed on these silicone tubes were fixed with 95% ethanol and stained with 0.1% crystal violet. After staining, the optical densities of biofilms were measured using spectrophotometer on a weekly basis for 12 weeks. RESULTS: Staphylococcus aureus group and Pseudomonas aeruginosa group formed significantly more amounts of biofilms compared to the control group. The maximum optical densities of the two groups were found on week 3-4 followed by a tendency of decrease afterwards. However, the amounts of biofilms formed in other groups of silicone tubes were not statistically significant from that of the control group. CONCLUSIONS: Bacterial species that could form biofilm on silicone tube included Staphylococcus aureus (week 3) and Pseudomonas aeruginosa (Week 4). It is important to first consider that the cause of infection around 1 month after silicone tube intubation can be Staphylococcus aureus and Pseudomonas aeruginosa.
Assuntos
Biofilmes/crescimento & desenvolvimento , Dacriocistorinostomia/instrumentação , Bactérias Gram-Positivas/fisiologia , Pseudomonas/isolamento & purificação , Stents/microbiologia , Análise de Variância , Bactérias Gram-Positivas/isolamento & purificação , Humanos , Ducto Nasolacrimal/cirurgia , Silicones , Especificidade da EspécieRESUMO
PURPOSE: To determine the relationship between the optical density of biofilms on silicone tubes and surgical outcomes. METHODS: A total of 43 silicone tubes from 33 patients with nasolacrimal duct stenosis were enrolled at 6 months after bicanalicular silicone tube intubation. The removed silicone tubes were divided into 2 segments. One segment of silicone tube was cultured while the other segment was used to measure optical density of biofilm. Each segment was divided into 3 pieces according to average normal human nasolacrimal anatomy. The first piece was located from puncta to lacrimal sac. The second piece was inside the nasolacrimal duct. The third piece was in the nasal cavity. Surgical outcome was evaluated at postoperative 12 months based on Munk score and fluorescein dye disappearance test. RESULTS: A total of 31 (72.1%) patients were surgically successful while 12 (27.9%) patients had surgical failure with persistent epiphora. In the second piece of silicone tube, the mean optical density of biofilm was 0.2654ânm in the surgical success group and 0.4472ânm in the surgical failure group. These results showed statistically significant (Pâ<â0.01) difference. The most frequently isolated organism was Staphylococcus aureus in the surgical success group (7 of 31 patients, 22.6%). It was Pseudomonas aeruginosa in the surgical failure group (6 of 12 patients, 50%). CONCLUSION: This is the first study that determines the relationship between biofilm on silicone tube and surgical outcome. Biofilm formed on silicone tubes in nasolacrimal duct might cause surgical failure.
Assuntos
Biofilmes , Doenças do Aparelho Lacrimal , Ducto Nasolacrimal/microbiologia , Próteses e Implantes/microbiologia , Dacriocistorinostomia , Humanos , Doenças do Aparelho Lacrimal/etiologia , Doenças do Aparelho Lacrimal/microbiologia , Doenças do Aparelho Lacrimal/cirurgia , Infecções por Pseudomonas , Pseudomonas aeruginosa , Silicones , Infecções Estafilocócicas , Staphylococcus aureusRESUMO
Although the wound healing effects of nitric oxide (NO) are known, the mechanism by which NO modulates corneal wound healing remains unclear. In this study, we investigated the effect of exogenous NO donor (NaNO2) on corneal wound healing. We found that NaNO2 (0.1 µM to 100 µM) increased human corneal epithelial cell (HCEC) viability and migration. It also modulated the phosphorylation of mitogen-activated protein kinases (MAPKs) in a time- dependent manner in those HCECs. Further, p38 MAPK phosphorylation increased at 6 h and normalized at 24 h, while the phosphorylation of extracellular signal regulated kinase (ERK) was increased both at 6 h and 24 h. Topical treatment with NaNO2 (10 µM) enhanced corneal epithelial healing and decreased corneal opacity in murine corneal alkali burn model by modulating inflammatory cytokines. Our findings suggest that NO increased HCEC proliferation and migration via time-dependent MAPK activation and eventually enhanced corneal recovery from the alkali burn.
Assuntos
Sobrevivência Celular/fisiologia , Lesões da Córnea/metabolismo , Células Epiteliais/metabolismo , Epitélio Corneano/metabolismo , Óxido Nítrico/metabolismo , Cicatrização/fisiologia , Animais , Queimaduras Químicas/metabolismo , Queimaduras Químicas/fisiopatologia , Movimento Celular/fisiologia , Proliferação de Células/fisiologia , Células Cultivadas , Córnea/metabolismo , Córnea/fisiopatologia , Lesões da Córnea/fisiopatologia , Células Epiteliais/fisiologia , Epitélio Corneano/fisiopatologia , MAP Quinases Reguladas por Sinal Extracelular/metabolismo , Queimaduras Oculares/metabolismo , Queimaduras Oculares/fisiopatologia , Humanos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Fosforilação/fisiologia , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismoRESUMO
Two patients with depigmentation and fat atrophy after an intralesional injection of triamcinolone acetonide (TA) to treat chalazion are reported. A 2-year-old girl with chalazion in her right lower eyelid received a subconjunctival injection of TA and developed fat atrophy and depigmentation around the injected area. These changes subsided after 7 months. The second patient was a 5-year-old boy who received a triamcinolone injection into a chalazion through the eyelid skin and also developed fat atrophy and depigmentation but these changes improved after 1 year.
Assuntos
Calázio/tratamento farmacológico , Doenças Palpebrais/induzido quimicamente , Pálpebras/patologia , Triancinolona Acetonida/efeitos adversos , Atrofia/induzido quimicamente , Atrofia/diagnóstico , Calázio/patologia , Pré-Escolar , Doenças Palpebrais/patologia , Pálpebras/efeitos dos fármacos , Feminino , Glucocorticoides/administração & dosagem , Glucocorticoides/efeitos adversos , Humanos , Injeções Intralesionais/efeitos adversos , Masculino , Triancinolona Acetonida/administração & dosagemRESUMO
OBJECTIVE: To evaluate the effects of applying sodium hyaluronate solution (Protad) intraoperatively during endonasal dacryocystorhinostomy. METHODS: A retrospective medical record review of all 254 patients (254 eyes) who underwent endonasal dacryocystorhinostomy for nasolacrimal duct obstruction was performed. The success rates and postoperative complications of the Protad application group (105 eyes) and the control group (149 eyes) were compared. RESULTS: The Protad group had better anatomical (96.2% vs 86.6%, p = 0.010) and functional (93.3% vs 85.2%, p = 0.046) surgical success rates. Granuloma developed less frequently in the Protad group (11.4% vs 32.9%, p < 0.001). Regarding secondary outcomes, synechia was less frequent in the Protad group, but the difference was not statistically significant (p = 0.283). Crust and infection rates were also lower in the Protad group (6.7% vs 11.4% for crust, 7.6% vs 8.1% for infection), but the difference was not statistically significant (p = 0.203 and p = 0.899, respectively). The rate of revision surgery was significantly lower in the Protad group compared to the control group (1.9% vs 14.1%, p < 0.001). Granuloma had the largest effects on anatomical and functional surgical success (odds ratio, 72.221 for anatomical and 19.915 for functional). CONCLUSIONS: The application of Protad effectively reduced postoperative granulation and enhanced surgical success rate after endonasal dacryocystorhinostomy. We suggest that Protad is a good nasal dressing material, especially for beginners in endoscopic surgery who work on Asian patients with narrow nasal cavities.
Assuntos
Dacriocistorinostomia/métodos , Ácido Hialurônico/administração & dosagem , Obstrução dos Ductos Lacrimais/terapia , Ducto Nasolacrimal/cirurgia , Cirurgia Endoscópica por Orifício Natural/métodos , Complicações Pós-Operatórias/prevenção & controle , Adjuvantes Imunológicos/administração & dosagem , Administração Tópica , Feminino , Seguimentos , Humanos , Período Intraoperatório , Obstrução dos Ductos Lacrimais/diagnóstico , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: To demonstrate the effectiveness of the endoscopic transcaruncular and transconjunctival approach in the repair of combined medial and inferior orbital wall fractures. METHODS: A retrospective chart review was conducted on 160 patients with combined medial and inferior orbital wall fractures. All patients underwent surgery via an endoscopic transcaruncular and transconjunctival approach without lateral canthotomy, performed by a single surgeon. Porous polyethylene sheets (1.0âmm in thickness) were implanted to cover the orbital defects. The minimal postoperative follow-up period was 6 months. The authors evaluated enophthalmos, diplopia, and ocular motility pre and postoperatively and report surgical complications. RESULTS: A total of 160 patients were included, comprising 121 men and 39 women. The mean patient age was 33.9â±â14.1 years, and the mean postoperative follow-up period was 12 months. The average enophthalmos was 3.20âmm preoperatively, and the mean improvement at 6 months after surgery was 2.82âmm. One patient suffered a canalicular laceration after surgery, and another retrobulbar hemorrhage; however, both of these complications resolved with appropriate management. Otherwise, there were no significant surgical complications including newly developed diplopia, decreased visual acuity, or cerebrospinal fluid leakage. CONCLUSIONS: The endoscopic transcaruncular and transconjunctival approach is a useful and promising technique to repair combined medial and inferior orbital wall fractures.
Assuntos
Endoscopia/métodos , Fixação de Fratura/métodos , Fraturas Orbitárias/cirurgia , Adolescente , Adulto , Idoso , Criança , Túnica Conjuntiva , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Resultado do Tratamento , Adulto JovemRESUMO
PURPOSE: Reconstruction of a large orbital fracture extending to the posterior wall of the maxillary sinus is difficult and challenging. In this study, the authors present transconjunctival or transcaruncular approach using endoscopy and layered porous polyethylene barrier sheets to manage large orbital floor wall fracture. METHODS: A retrospective review of all patients who underwent reconstruction of large orbital floor wall fractures between June 2009 and July 2015 was conducted. Patient demographics, degree of enophthalmos, ocular motility and diplopia test results, and surgical complications were reviewed. RESULTS: This study included 53 eyes of 53 patients. The mean time from trauma to surgery was 34.1 days (range, 1-360 days). The average postoperative follow-up period was 6.1 months (range, 3-14 months). The degrees of enophthalmos preoperatively, and 1 week, 1 month, and 3 months postoperatively were -1.98âmm (range, -1.5 to -3 mm), 0.13âmm (range, -1.0 to +1.5 mm), -0.09âmm (range, -2.0 to +1.5 mm), and -0.43âmm (range, -2.0 to +1.0 mm), respectively. The mean improvement in enophthalmos at 3 months postoperation was 1.55âmm (P < 0.001). There was only 1 patient with residual 2âmm enophthalmos at 3 months postoperation. There were no definite surgical complications in any patient. CONCLUSION: Sufficient dissection to the posterior extent of the fracture and reconstruction of the orbital floor slope are the most important surgical factors to prevent residual enophthalmos. The authors believe using an endoscope and layered porous polyethylene are effective techniques in challenging patients with large orbital wall fracture.
Assuntos
Endoscopia/métodos , Fixação de Fratura/métodos , Fraturas Orbitárias/cirurgia , Adolescente , Adulto , Criança , Endoscópios , Endoscopia/instrumentação , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Adulto JovemRESUMO
Ocular drug delivery is an interesting field in current research. Silica nanoparticles (SiNPs) are promising drug carriers for ophthalmic drug delivery. However, little is known about the toxicity of SiNPs on ocular surface cells such as human corneal epithelial cells (HCECs). In this study, we evaluated the cytotoxicity induced by 50, 100 and 150 nm sizes of SiNPs on cultured HCECs for up to 48 hours. SiNPs were up-taken by HCECs inside cytoplasmic vacuoles. Cellular reactive oxygen species generation was mildly elevated, dose dependently, with SiNPs, but no significant decrease of cellular viability was observed up to concentrations of 100 µg/ml for three different sized SiNPs. Western blot assays revealed that both cellular autophagy and mammalian target of rapamycin (mTOR) pathways were activated with the addition of SiNPs. Our findings suggested that 50, 100 and 150 nm sized SiNPs did not induce significant cytotoxicity in cultured HCECs.
Assuntos
Células Epiteliais/citologia , Epitélio Corneano/citologia , Nanopartículas/toxicidade , Dióxido de Silício/toxicidade , Apoptose/efeitos dos fármacos , Autofagia/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Células Epiteliais/efeitos dos fármacos , Células Epiteliais/metabolismo , Glutationa/metabolismo , Humanos , Marcação In Situ das Extremidades Cortadas , Espaço Intracelular/metabolismo , L-Lactato Desidrogenase/metabolismo , Nanopartículas/ultraestrutura , Estresse Oxidativo/efeitos dos fármacos , Tamanho da Partícula , Espécies Reativas de Oxigênio/metabolismo , Transdução de Sinais/efeitos dos fármacos , Eletricidade Estática , Serina-Treonina Quinases TOR/metabolismoRESUMO
BACKGROUND: To investigate the alleviation effect of Vaccinium uliginosum extract (DA9301) on tablet computer-induced asthenopia. METHODS: This was a randomized, placebo-controlled, double-blind and parallel study (Trial registration number: 2013-95). A total 60 volunteers were randomized into DA9301 (n = 30) and control (n = 30) groups. The DA9301 group received DA9301 oral pill (1000 mg/day) for 4 weeks and the control group received placebo. Asthenopia was evaluated by administering a questionnaire containing 10 questions (responses were scored on a scales of 0-6; total score: 60) regarding ocular symptoms before (baseline) and 4 weeks after receiving pills (DA9301 or placebo). The participants completed the questionnaire before and after tablet computer (iPad Air, Apple Inc.) watching at each visit. The change in total asthenopia score (TAS) was calculated and compared between the groups RESULTS: TAS increased significantly after tablet computer watching at baseline in DA9301 group. (from 20.35 to 23.88; p = 0.031) However, after receiving DA9301 for 4 weeks, TAS remained stable after tablet computer watching. In the control group, TAS changes induced by tablet computer watching were not significant both at baseline and at 4 weeks after receiving placebo. Further analysis revealed the scores for "tired eyes" (p = 0.001), "sore/aching eyes" (p = 0.038), "irritated eyes" (p = 0.010), "watery eyes" (p = 0.005), "dry eyes" (p = 0.003), "eye strain" (p = 0.006), "blurred vision" (p = 0.034), and "visual discomfort" (p = 0.018) significantly improved in the DA9301 group. CONCLUSIONS: We found that oral intake of DA9301 (1000 mg/day for 4 weeks) was effective in alleviating asthenopia symptoms induced by tablet computer watching. TRIAL REGISTRATION: The study is registered at www.clinicaltrials.gov (registration number: NCT02641470, date of registration December 30, 2015).
Assuntos
Antioxidantes/uso terapêutico , Astenopia/tratamento farmacológico , Mirtilos Azuis (Planta)/química , Extratos Vegetais/uso terapêutico , Administração Oral , Adulto , Antioxidantes/administração & dosagem , Computadores , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Extratos Vegetais/administração & dosagem , Inquéritos e Questionários , Adulto JovemRESUMO
PURPOSE: To present a surgical technique for the reconstruction of the orbital floor slope in patients of isolated orbital floor fracture and to evaluate the effectiveness of this technique. METHODS: The authors conducted a retrospective review of all patients who underwent reconstruction of isolated orbital floor wall fracture between June 2010 and July 2015. The authors reviewed patient demographics, degree of enophthalmos, ocular motility and diplopia test results, and surgical complications. RESULTS: This study included 33 eyes from 33 patients. The mean time interval from trauma to surgery was 24.9 days (range, 5-360 days). The average postoperative follow-up period was 7.4 months (range, 3-28 months). The degree of enophthalmos preoperatively and 1 week, 1 month, and 3 months postoperatively was -1.55âmm (range, -3 to -0.5 mm), 0.22âmm (range, -0.5 to +1.0 mm), -0.06âmm (range, -1.0 to +1.0 mm), and -0.13âmm (range, -0.5 to +0.5 mm), respectively. The mean improvement in enophthalmos at postoperative 3 months was 1.41âmm compared with that in the preoperative data (P value <0.001). There were no patients with residual enophthalmos greater than 1âmm after reconstruction. CONCLUSION: Endoscopic orbital floor slope reconstruction in isolated orbital floor wall fracture using a layered porous polyethylene barrier implant is a very useful surgical technique for safely identifying the posterior margin of a fracture and easily reconstructing the orbital floor slope. The demonstration of slight exophthalmos of the corrected side about 1 to 2âmm at the end of the operation was also necessary.
Assuntos
Enoftalmia/cirurgia , Órbita/cirurgia , Fraturas Orbitárias/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oftalmoscopia/métodos , Polietilenos , Próteses e Implantes , Estudos Retrospectivos , Adulto JovemRESUMO
PURPOSE: To present a transconjunctival and transcaruncular endoscopy approach involving layered porous polyethylene barrier implants to manage residual posttraumatic enophthalmos and to evaluate the effectiveness of this technique. METHODS: The authors performed a retrospective review of all patients who underwent secondary reconstruction of orbital wall fractures because of residual enophthalmos between June 2008 and July 2015. Patients' demographics, degree of enophthalmos, ocular motility, diplopia test results, and surgical complications were reviewed. RESULTS: This study included 16 eyes (4 right eyes and 12 left eyes) of 16 patients (14 males and 2 females). The mean time interval from trauma to surgery was 7.1 months (range, 1-18 months). The average postoperative follow-up period was 6.4 months (range, 3-18 months). The degree of enophthalmos preoperatively and at 1 week, 1 month, and 3 months postoperatively was -2.47 mm (range, -2 to -3 mm), 0.5 mm (range, -0.5 to +2.5 mm), -0.06 mm (range, -0.5 to +1.5 mm), and -0.44 mm (range, -1.5 to +1.0 mm), respectively. There were no definite surgical complications in any patients. CONCLUSION: Dissection to the posterior margin of the fracture and reconstruction of the orbital floor slope are the most important surgical factors to prevent residual enophthalmos and scarring with recurrent diplopia. Demonstration of slight exophthalmos of the corrected side of about 1 to 2 mm at the end of the operation is also necessary. The authors believe that surgery using an endoscope and layered porous polyethylene is very useful for secondary reconstruction.